Repetitive Transcranial Magnetic Stimulation and the Development of Ongoing Muscle Pain
Pain Relief
About this trial
This is an interventional treatment trial for Pain Relief focused on measuring nerve growth factor, repetitive transcranial magnetic stimulation, dorsolateral prefrontal cortex
Eligibility Criteria
Inclusion Criteria:
- Healthy men and women
- Speak and understand English.
Exclusion Criteria:
- Pregnancy
- Drug addiction defined as the use of cannabis, opioids or other drugs
- Previous neurologic, musculoskeletal or mental illnesses
- Lack of ability to cooperate
- History of chronic pain or current acute pain
- Previous experience with rTMS
- Contraindications to rTMS application (history of epilepsy, metal in the head or jaw etc.).
- Failure to pass the "TASS questionnaire" (TASS = Transcranial Magnetic Stimulation Adult Safety Screen)
Sites / Locations
- Aalborg University
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
Real treatment group
Sham treatment group
Transcranial magnetic stimulation (TMS) is used to stimulate small regions of the brain. During a TMS procedure, a magnetic field generator, or "coil", is placed near the head of the person receiving the treatment. The coil produces small electric currents in the region of the brain just under the coil via electromagnetic induction. The protocol used in this research includes 20 minutes of 10Hz stimulation, 5 seconds on, 10 seconds off, at 110% RMT, for a total of 4000 pulses.
Sham coil is used to mimic the clicking sound of the TMS coil and skin stimulation