Effect of Non-surgical Periodontal Treatment on Oxidative Stress and Antioxidant Status in OSAS (OSAS)

Effect of Non-surgical Periodontal Treatment on Oxidative Stress and Antioxidant Status in Obstructive Sleep Apnea Syndrome (OSAS)

The main objective of this study is to investigate whether the non-surgical periodontal treatment of patients with periodontitis and obstructive sleep apnea syndrome (OSAS) affects the prognosis of OSAS positively with polysomnographic, serum and saliva parameters.

There is evidence supporting that OSAS is an independent risk factor for cardiovascular and cerebrovascular diseases such as hypertension, congestive heart failure, myocardial infarction, cardiac-arrhythmia, and stroke.Gender, age, smoking, obesity and diabetes, which are risk factors for periodontitis,It is also common in OSAS at the same time.In addition to common risk factors, both OSAS and periodontitis have been shown to be associated with increased cystic inflammation.It has been reported that elevated inflammatory markers in OSAS patients may be associated with periodontal inflammation, although the mechanism of OSAS to systemic inflammation has not yet been clarified. The investigators aimed to investigate whether the non-surgical periodontal treatment of patients with periodontitis and obstructive sleep apnea syndrome (OSAS) affects the course of OSAS positively with polysomnographic, serum and saliva parameters.

It's an assessor blinded, parallel group, randomized controlled trial aimed at investigate whether the non-surgical periodontal treatment of patients with periodontitis and obstructive sleep apnea syndrome (OSAS) affects the prognosis of OSAS positively with polysomnographic, serum and saliva parameters.

Non-surgical periodontal therapy consisted of scaling and root planing and supportive periodontal therapy during 3 months Intervention: Procedure: Non-surgical periodontal therapy

Experimental: Non-surgical periodontal therapy (scaling and root planing) and supportive periodontal therapy

Inclusion Criteria: aged ≥18 years old having more than 16 teeth BMI>25 kg/m2 Exclusion Criteria: patients with a history of diabetes mellitus or respiratory diseases patients who were under any medication that was known to influence periodontal tissues patients with a history of any periodontal treatment in the past 6 months patients with hormonal changes such as pregnancy or lactation; and 5) patients having fixed dentures or removable prothesis OSAS treatment started (using OSAS therapy device or undergoing surgical operation)

Loke W, Girvan T, Ingmundson P, Verrett R, Schoolfield J, Mealey BL. Investigating the association between obstructive sleep apnea and periodontitis. J Periodontol. 2015 Feb;86(2):232-43. doi: 10.1902/jop.2014.140229. Epub 2014 Oct 9.

Gamsiz-Isik H, Kiyan E, Bingol Z, Baser U, Ademoglu E, Yalcin F. Does Obstructive Sleep Apnea Increase the Risk for Periodontal Disease? A Case-Control Study. J Periodontol. 2017 May;88(5):443-449. doi: 10.1902/jop.2016.160365. Epub 2016 Nov 18.

DPTT study group; Engebretson S, Gelato M, Hyman L, Michalowicz BS, Schoenfeld E. Design features of the Diabetes and Periodontal Therapy Trial (DPTT): a multicenter randomized single-masked clinical trial testing the effect of nonsurgical periodontal therapy on glycosylated hemoglobin (HbA1c) levels in subjects with type 2 diabetes and chronic periodontitis. Contemp Clin Trials. 2013 Nov;36(2):515-26. doi: 10.1016/j.cct.2013.09.010. Epub 2013 Sep 27.