Risk-Reducing Surgeries for Hereditary Ovarian Cancer
Hereditary Breast and Ovarian Cancer Syndrome, Colorectal Neoplasms, Hereditary Nonpolyposis, Ovariectomy
About this trial
This is an interventional prevention trial for Hereditary Breast and Ovarian Cancer Syndrome
Eligibility Criteria
Inclusion Criteria:
- Carriers with known and definite mutation genes of hereditary ovarian cancer.
- With children and without further requirement of pregnancy.
- No less than 35 years for carriers with mutation gene of BRCA1.
- No less than 40 years for carriers with mutation gene of BRCA2.
- No less than 45 years for carriers with mutation genes of BRIP1, RAD51C, RAD51D and RAD51.
- No less than 50 years for carriers with mutation genes of ATM, MSH2, MLH1, SH6, PMS2, EPCAM and STK11.
Exclusion Criteria:
- Without children.
- Not reaching appreciate ages.
- With contraindications of laparoscopy.
- Refusal of risk-reducing surgeries.
Sites / Locations
- Lei LiRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Other
HBOCS
Lynch syndromes
Refusal to surgery
For carriers with mutation genes of BRCA1, BRCA2 (both belonging to mutation genes of hereditary breast and ovarian cancer syndrome, HBOCS) and ATM, BRIP1, RAD51, RAD51C, and RAD51D (all belonging to mutation genes of other hereditary ovarian cancer syndrome), if they demand for risk-reducing surgeries, counseling, decision-making analysis, then salpingo-oophorectomy only by laparoscopy and long-term follow-up are provided.
for carriers with mutation genes of MLH1, MSH2, MSH6, PMS2, EPCAM (all belonging to mutation genes of Lynch syndromes) and STK11, , if they demand for risk-reducing surgeries, counseling, decision-making analysis, then salpingo-oophorectomy with hysterectomy by laparoscopy and long-term follow-up are provided.
For carriers with any mutation genes (BRCA1, BRCA2, ATM, BRIP1, RAD51, RAD51C, RAD51D, STK11, MLH1, MSH2, MSH6, PMS2 and EPCAM) but refusal to any risk-reducing surgeries, counseling, decision-making analysis, and then long-term follow-up are provided.