The ACT Trial: Effects of Combined Aerobic Exercise and Cognitive Training in MCI
Mild Cognitive Impairment
About this trial
This is an interventional treatment trial for Mild Cognitive Impairment focused on measuring cognitive impairment, Alzheimer's disease, exercise, cognitive training, imaging
Eligibility Criteria
Inclusion Criteria:
- A clinical diagnosis of MCI, Community-dwelling, Age 65 years and older, English-speaking, Adequate visual acuity, Verified exercise safety by medical provider, Stable on drugs affecting cognitive and psychological status, Verified MRI safety, and Capacity to consent.
Exclusion Criteria:
- Geriatric Depression Scale < 5, Resting heart rate (HR) ≤50 due to arrhythmia or ≥100 beats/min, Neurological (e.g., dementia, head trauma), psychiatric (e.g., bipolar, schizophrenia, or depression), or substance dependency (alcohol or chemical dependency) in the past 5 years that are the main contributor to MCI, Contraindications to exercise, e.g. unstable angina, recent surgery, New symptoms or diseases that have not been evaluated by a health care provider, Current enrollment in another intervention study related to cognitive improvement (reduce confounding effects on outcomes), and Abnormal MRI findings.
Sites / Locations
- Arizona State UniversityRecruiting
- University of MinnesotaRecruiting
- University of RochesterRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Active Comparator
Experimental
Sham Comparator
Cycling Only
Cognitive Training Only
ACT
Stretching and Mental Stimulation Activities
Moderate-intensity cycling, 3 times a week for 6 months, supervised by an exercise specialist
Computerized cognitive training, 3 times a week for 6 months, supervised by a specialist
Moderate-intensity cycling followed by computerized cognitive training, 3 times a week for 6 months, supervised by a specialist
Stretching and mental stimulation activities, 3 times a week for 6 months, supervised by a specialist