Comparison of CLSB With Sedation Versus General Endotracheal Anesthesia on Postoperative Outcomes in Elderly Patients Undergoing Hip Fracture Surgery
Anesthesia Morbidity, Anesthesia; Adverse Effect
About this trial
This is an interventional treatment trial for Anesthesia Morbidity focused on measuring general anesthesia, sacral plexus block, lumbar plexus block, hip fracture, elderly
Eligibility Criteria
Inclusion Criteria:
- Age ≥77 years old;
- First unilateral surgery for hip fracture including femoral neck, intertrochanteric or subtrochanteric fracture;
- Patient with planned hip fracture surgery within 24-72 h;
- Patient without peripheral nerve block within 24 h prior to surgery;
- The ability to receive written informed consent from the patient or patient's legal representative.
Exclusion Criteria:
- Refuse to participate;
- Unable to perform nerve block;
- Multiple trauma, multiple fractures or other fractures outside the inclusion criteria, such as pathological fractures, pelvic fractures, femur fractures;
- Prosthetic fracture;
- Scheduled for bilateral hip fracture surgery;
- Usage of bone-cement fixation in the surgery;
- With recent cerebral stroke (<3 months);
- Combined with active heart disease (unstable angina, acute myocardial infarction, recent myocardial infarction; decompensated heart failure; symptomatic arrhythmia; severe mitral or aortic stenotic heart disease);
- Patient with known severe lung and/or airway disease, acute respiratory failure, acute pulmonary infection, and acute attack of bronchial asthma;
- Current enrolment in another clinical trial;
- Contraindication for general endotracheal anesthesia(drug allergies to general anesthesia, difficult airway);
- Contraindication for lumbar and sacral plexus block(infection at the site of needle insertion, coagulopathy, allergy to local anesthetics).
Sites / Locations
- Shanghai Sixth People's HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
GA group
CLSB group
general anesthesia(GA) group: Open peripheral vein fluid infusion, radial arterial cannulation under local lidocaine anesthesia and arterial blood pressure monitoring Propofol (1.5-3mg/kg), cis-atracurium(0.1-0.15mg/kg) and sulfentanyl(0.2-0.6μg/kg) anesthesia-induced intubation, mechanical ventilation to maintain normal PETCO2 Use sevoflurane, propofol and sulfentanyl to maintain anesthesia, and add cis-atracurium as needed Transfer to ICU after surgery
combined lumbar plexus and sacral plexus block(CLSB) group: Open peripheral vein fluid infusion In lateral position (affected side upward), ultrasound-guided lumbar plexus block (0.375% ropivacaine, Lumbar 2-3 or/and 3-4vertebral space level, 25ml), then sacral plexus block (0.375% ropivacaine, 20ml) Radial arterial cannulation under local lidocaine anesthesia and arterial blood pressure monitoring, and blockade effectiveness was evaluated 30min after nerve block After reaching satisfactory blockade, target-controlled infusion of propofol was used to maintain Ramsay sedation score between 5-6 points, monitoring PETCO2 through nasopharyngeal airway, maintain autonomous respiration, and add small-dose fentanyl (10-20μg/time) as needed Transfer to ICU after surgery