Clinical Efficacy and Immune Effects of Acupuncture in Patients With Comorbid Chronic Pain and Major Depression Disorder
Chronic Pain, Depression
About this trial
This is an interventional treatment trial for Chronic Pain focused on measuring Acupuncture, Chronic pain, Major depressive disorder, Biomarkers, Gene, Comorbidity
Eligibility Criteria
Inclusion Criteria:
- Age ≥ 20 years
- they will be diagnosed with DSM-V as major depressive disorder
- they will be rated ≥ 18 on the 21-item Hamilton Rating Scale
- Clinical Global Impression: moderate
- there will be no change of dosages or types of in medications or psychotherapy for more than 4 weeks before the enrolment
- the pain persist more than 3 months and the score of 5th item of Brief Pain Inventory more than 4
- patients never receive acupuncture and herbs within two weeks before enrollment (Whether the previous acupuncture or herbs will interfere the inclusion depends on the judgement of the therapists)
Exclusion Criteria:
- Major depressive disorder caused by substance abuse or pregnancy
- organic major depressive disorder
- Major psychiatric depression other than major depression
- first onset of major depressive disorder after 65 years old
- Malignant pain caused by Cancer pain syndrome
- Headache and visceral pain such as stomachache
- referred pain such as back pain caused by pancreatitis
Sites / Locations
- China Medical University HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Acupuncture for Depression/Acupuncture for pain
Acupuncture for pain/Acupuncture for Depression
The computer-generated permuted block randomization was used so that the participating patients were randomly assigned on an exactly 1:1 ratio to either the depression-pain group, in which the depression-specific acupoints were first targeted (12 sessions over six weeks), followed by the pain-specific acupoints (12 sessions over six weeks)
The computer-generated permuted block randomization was used so that the participating patients were randomly assigned on an exactly 1:1 ratio to either the depression-pain group, in which the pain-specific acupoints (six weeks 12 sessions) were first targeted followed by the depression-specific acupoints (six weeks 12 sessions).