Pulmonary Function Using Non-invasive Forced Oscillometry (PUFFOR)
Infant, Premature, Diseases, Infant, Newborn, Diseases, Bronchopulmonary Dysplasia
About this trial
This is an interventional diagnostic trial for Infant, Premature, Diseases
Eligibility Criteria
Inclusion Criteria:
- Infants with gestational age at least 22 weeks at birth
- Infants off ventilator/continuous positive airway pressure ≥ 12 hours
- Infants whose parents/legal guardians have provided consent
Exclusion Criteria:
- Infants with major malformation
- Infants with a neuromuscular condition that affects respiration
- Infants with terminal illness
- Infants with a decision made to withhold or limit support
Sites / Locations
- University of Alabama at BirminghamRecruiting
Arms of the Study
Arm 1
Experimental
Non-invasive forced airway oscillometry
Analyze lung function using forced airway oscillometry in preterm infants and term infants with and without lung disease with both cross-sectional and longitudinal comparisons. Aim 1: Lung function in term and preterm infants without lung disease (anticipated n=264) Aim 2: Lung function in preterm infants with respiratory distress syndrome (RDS) who develop bronchopulmonary dysplasia (BPD) and preterm infants with RDS who do not develop BPD (anticipated n=264) Aim 3: Lung function measurements in infants with common neonatal lung diseases (including RDS, BPD, meconium aspiration syndrome, and transient tachypnea of the newborn) and controls without lung disease (anticipated n=570) Aim 4: Lung function in infants with lung disease before and after common therapeutic interventions