Effect of Sodium Intake on Brain Natriuretic Peptide Levels in Patients With Heart Failure (SODA-HF)
Diet, Sodium-Restricted, Heart Failure, Systolic, Natriuretic Peptide, Brain
About this trial
This is an interventional treatment trial for Diet, Sodium-Restricted
Eligibility Criteria
Inclusion Criteria:
Patients with a diagnosis of stable heart failure and decreased left ventricular ejection fraction. Such definition will contemplate the following:
- Patients should have an echocardiogram of maximum 6 months old with a left ventricular ejection fraction of less than 40%.
- Functional class I, II or III of the NYHA
- Optimal medical treatment which should include: an angiotensin converting enzyme inhibitor or angiotensin receptor blocker ARA, and a beta-blocker; or inability to tolerate these medications.
- No changes in pharmacological treatment in the last 4 weeks.
- Systolic blood pressure greater than or equal to 90 mmHg.
- Informed consent to participate in the study.
Exclusion Criteria:
A hospitalization for heart failure less than one month ago. Chronic kidney disease: glomerular filtration rate estimated by the formula of CKD-EPI <30 ml / min / 1.73 m2.
Hyponatremia: Sodium less than 130 mmol / l. Anemia: Hemoglobin less than 10 g / dl. Patients who will be taken to any type of intervention in the next 12 months in order to improve ventricular function, such as percutaneous coronary intervention or surgical revascularization Any valvulopathy of severe degree. Dementia Cancer Patients who have planned change of address in the next 12 months.
Sites / Locations
- Hospital de Cardiología, Centro Médico Nacional Siglo XXI
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Severe sodium restriction
Moderate sodium restriction.
Patients will be assigned to a diet with two grams of sodium. The nutritionist will be responsible for calculating diets appropriate to the needs of each patient. The diet will not have the intention to modify the weight of the patient but only to indicate the menus that the patients will follow. All the patients will be explained the diet. Patients will be allowed a maximum intake of 1.5 liters of water per day, including the liquid of soups, juices and drinks; This will be explained in detail to the patients. The diets will be identical in calories according to the weight of the patient. The only difference in diets will be the sodium content, which will be 2 grams of sodium vs. 3 grams of sodium.
Patients will be assigned to a diet with three grams of sodium.