Evaluation of the ORTHO-LBNP System (ORTHO-LBNP)
Orthostatic Hypotension, Ischemia, Hypoxia
About this trial
This is an interventional basic science trial for Orthostatic Hypotension focused on measuring Gz accelerations, Head up tilt (HUT) test, Lower body negative pressure (LBNP) method, Physiological parameters, Variable gravitational stimuli
Eligibility Criteria
Inclusion Criteria:
- Pilots or cadets with flight experience
- Candidates for pilots without flight experience
- None alcohol 24 hours prior to the study
- Written informed consent
Exclusion Criteria:
- Subjects with cardiovascular disorders
Sites / Locations
- Military Institute of Aviation Medicine
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Stimuli of slowly increasing intensities
Stimuli of rapidly increasing intensities
300-s check before the stimuli LBNP is applied stepwise with 11.1 mmHg/15 s decrement to -100 mmHg, and then this value is sustained for 120 s 180-second phase of rest between stimuli 75°-HUT (5°/s) for 120 s after a 15-s reversing of the gravity vector (-30°) 180-second phase of rest between stimuli 75°-HUT (5°/s) accompanied by an exposure to an LBNP of -60 mmHg increased linearly by -4 mmHg/s, and then this value is sustained for 120 s during HUT 120-s check after the stimuli
120-s check before the stimuli 75°-HUT (45°/s) for 60 s after a 3-s reversing of the gravity vector (-30°) 180-second phase of rest between stimuli LBNP decreases linearly by -20 mmHg/s to -100 mmHg, and then this value is sustained for 60 s. 180 second phase of rest between stimuli push-pull, i.e., 3 x 75°-HUT (45°/s) preceded by -30°-HDT (45°/s) and accompanied by an exposure to an LBNP of -60 mmHg decreased linearly by -20 mmHg/s, and then this value is sustained for 30 s during HUT 120-s check after the stimuli