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THALES - Acute STroke or Transient IscHaemic Attack Treated With TicAgreLor and ASA for PrEvention of Stroke and Death (THALES)

Primary Purpose

Acute Ischaemic Stroke, Transient Ischaemic Attack

Status

Completed

Phase

Phase 3

Locations

International

Study Type

Interventional

Intervention

Ticagrelor

Placebo

About this trial

This is an interventional treatment trial for Acute Ischaemic Stroke focused on measuring Acute ischaemic stroke; Transient Ischaemic Attack (TIA); Stroke

Eligibility Criteria

40 Years - 130 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

Provision of signed informed consent prior to any study-specific procedure
≥40 years of age
Acute onset of cerebral ischaemia due to
1. AIS with NIHSS ≤5. AIS is defined as acute onset of neurological deficit attributed to focal brain ischaemia, and either of the following:
  - Persistent signs or symptoms of the ischaemic event at the time o randomisation, OR
  - Acute ischaemic brain lesion documented before randomisation by computed tomography (CT) scan or magnetic resonance imaging (MRI) (diffusion-weighted imaging) and that could account for the clinical presentation
2. High-risk TIA, defined as neurological deficit of acute onset attributed to focal ischaemia of the brain by history or examination with complete resolution of the deficit, and at least one of the following:
  - ABCD2 score ≥6 and TIA symptoms not limited to isolated numbness, isolated visual changes, or isolated dizziness/vertigo
  - Symptomatic intracranial arterial occlusive disease that could account for the clinical presentation, documented by transcranial Doppler or vascular imaging and defined as at least 50% narrowing in the diameter of the vessel lumen
  - Internal carotid arterial occlusive disease that could account for the clinical presentation, documented by Doppler, ultrasound, or vascular imaging and defined as at least 50% narrowing in diameter of the vessel lumen
Randomisation occurring within 24 hours after onset of symptoms; for wake-up strokes (when the time of symptom onset is not known), within 24 hours from the time point at which the patient was reported to be in their normal condition
CT or MRI performed after symptom onset ruling out intracranial haemorrhage or other pathology, such as vascular malformation, tumour, or abscess that according

to the Investigator could explain symptoms or contraindicate study treatment

Exclusion Criteria:

Need for or an anticipated need for any of the following:
1. Dual antiplatelet therapy with ASA and P2Y12 inhibitors (including patients with carotid artery stenting and percutaneous coronary intervention)
2. Antiplatelets other than ASA (eg, GPIIb/IIIa inhibitors, clopidogrel, ticlopidine, prasugrel, dipyridamole, ozagrel, cilostazol, ticagrelor) and other antithrombotic agents with antiplatelet effects, including traditional/herbal medicine agents
3. Anticoagulants (eg, warfarin, oral thrombin and factor Xa inhibitors, bivalirudin, hirudin, argatroban, fondaparinux, or unfractionated heparin and long-term treatment with low-molecular weight heparins). Short-term treatment (≤7 days) with low-dose low-molecular weight heparin may be used in immobilised patients at the discretion of the Investigator
Any history of atrial fibrillation/flutter, ventricular aneurysm, or suspicion of other cardioembolic pathology for TIA or stroke
Patients who should receive or have received any intravenous or intra-arterial thrombolysis or mechanical thrombectomy within 24 hours prior to randomisation
Planned carotid endarterectomy that requires halting investigational product within 3 days of randomisation or is expected to require unblinding of investigational product (planned carotid endarterectomy is in itself not an exclusion criterion)
History of previous intracranial haemorrhage at any time (asymptomatic microbleeds do not qualify), gastrointestinal haemorrhage within the past 6 months, or major surgery within 30 days
Patients considered to be at risk of bradycardic events (eg, known sick sinus syndrome or second- or third-degree atrioventricular block) unless already treated with a permanent pacemaker
Inability of the patient to understand and/or comply with study procedures and/or follow-up, in the opinion of the Investigator
Known hypersensitivity to ticagrelor or ASA
Need for or an anticipated need for oral or intravenous therapy with any of the following:
1. Strong cytochrome P450 3A (CYP3A4) inhibitors (eg, ketoconazole, clarithromycin [but not erythromycin or azithromycin], nefazadone, ritonavir, atazanavir) that cannot be stopped for the course of the study
2. Long-term (>7 days) non-steroidal anti-inflammatory drugs
Known bleeding diathesis or coagulation disorder (eg, thrombotic thrombocytopenic purpura)
Known severe liver disease (eg, ascites or signs of coagulopathy)
Renal failure requiring dialysis
Pregnancy or breastfeeding. Women of child-bearing potential who are not willing to use a medically accepted method of contraception that is considered reliable in the judgment of the Investigator
Involvement in the planning and/or conduct of the study (applies to both AstraZeneca staff and/or staff at the study site)
Previous enrolment or randomisation in the present study
Participation in another clinical study with an investigational product at any time during the 30 days prior to randomisation (regardless of when treatment with the investigational product was discontinued)

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Placebo Comparator

Arm Label

TICAGRELOR

TICAGRELOR PLACEBO

Arm Description

Outcomes

Primary Outcome Measures

Composite of Subsequent Stroke or Death

Participants with subsequent stroke or death

Secondary Outcome Measures

Ischaemic Stroke

Number of participants with ischaemic stroke

Number of Participants With Modified Rankin Scale (mRS) Score >1 at Visit 3

The modified Rankin Scale (mRS) is a scale for measuring the degree of disability or dependence in the daily activities of people who have suffered a stroke or other causes of neurological disability. The scale runs from 0-6, running from perfect health without symptoms to death.0 - No symptoms,1 - No significant disability. Able to carry out all usual activities, despite some symptoms. 2 - Slight disability. Able to look after own affairs without assistance, but unable to carry out all previous activities. 3 - Moderate disability. Requires some help, but able to walk unassisted. 4 - Moderately severe disability. Unable to attend to own bodily needs without assistance, and unable to walk unassisted. 5 - Severe disability. Requires constant nursing care and attention, bedridden, incontinent. 6 - Dead.

Full Information

NCT ID

NCT03354429

First Posted

November 20, 2017

Last Updated

December 21, 2020

Sponsor

AstraZeneca

1. Study Identification

Unique Protocol Identification Number

NCT03354429

Brief Title

THALES - Acute STroke or Transient IscHaemic Attack Treated With TicAgreLor and ASA for PrEvention of Stroke and Death

Acronym

THALES

Official Title

A Randomised, Double-Blind, Placebo-Controlled, International, Multicentre, Phase III Study to Investigate the Efficacy and Safety of Ticagrelor and ASA Compared With ASA in the Prevention of Stroke and Death in Patients With Acute Ischaemic Stroke or Transient Ischaemic Attack

Study Type

Interventional

2. Study Status

Record Verification Date

December 2020

Overall Recruitment Status

Completed

Study Start Date

January 22, 2018 (Actual)

Primary Completion Date

December 13, 2019 (Actual)

Study Completion Date

December 13, 2019 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

AstraZeneca

4. Oversight

Studies a U.S. FDA-regulated Drug Product

Studies a U.S. FDA-regulated Device Product

Product Manufactured in and Exported from the U.S.

Data Monitoring Committee

Yes

5. Study Description

Brief Summary

Study to investigate if the study drug ticagrelor and ASA is more effective than Placebo (inactive tablet) and ASA in preventing new stroke events

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Acute Ischaemic Stroke, Transient Ischaemic Attack

Keywords

Acute ischaemic stroke; Transient Ischaemic Attack (TIA); Stroke

7. Study Design

Primary Purpose

Treatment

Study Phase

Phase 3

Interventional Study Model

Parallel Assignment

Masking

ParticipantCare ProviderInvestigatorOutcomes Assessor

Allocation

Randomized

Enrollment

11016 (Actual)

8. Arms, Groups, and Interventions

Arm Title

TICAGRELOR

Arm Type

Experimental

Arm Title

TICAGRELOR PLACEBO

Arm Type

Placebo Comparator

Intervention Type

Drug

Intervention Name(s)

Ticagrelor

Intervention Description

Ticagrelor arm: Day 1, loading dose of ticagrelor followed by daily maintenance dose until Day 30.

Intervention Type

Drug

Intervention Name(s)

Placebo

Intervention Description

Placebo arm: Day 1, loading dose of placebo followed by placebo daily maintenance dose until Day 30.

Primary Outcome Measure Information:

Title

Composite of Subsequent Stroke or Death

Description

Participants with subsequent stroke or death

Time Frame

From randomisation (day 1) to visit 3 (day 30-34)

Secondary Outcome Measure Information:

Title

Ischaemic Stroke

Description

Number of participants with ischaemic stroke

Time Frame

From randomisation (day 1) to visit 3 (day 30-34)

Title

Number of Participants With Modified Rankin Scale (mRS) Score >1 at Visit 3

Description

Time Frame

Visit 3 (day 30-34)

Other Pre-specified Outcome Measures:

Title

Bleeding Event That Fulfils Serious Adverse Event Criteria and is Categorised as GUSTO Severe

Description

Participants with bleeding event that fulfils serious adverse event criteria and is categorised as GUSTO Severe. GUSTO is a bleeding scale (GUSTO = Global Utilization of Streptokinase and Tissue plasminogen activator for Occluded coronary arteries). GUSTO Severe bleeding is defined as any of the following: (1) fatal bleeding, (2) intracranial bleeding, or (3) bleeding that caused haemodynamic compromise requiring intervention

Time Frame

From randomisation (day 1) to visit 3 (day 30-34)

Title

ICH or Fatal Bleeding Event

Description

Participants with ICH or fatal bleeding event

Time Frame

From randomisation (day 1) to visit 3 (day 30-34)

Title

Bleeding Event That Fulfils Serious Adverse Event Criteria and is Categorised as GUSTO Moderate/Severe

Description

Participants with bleeding event that fulfils serious adverse event criteria and is categorised as GUSTO Moderate/Severe. GUSTO is a bleeding scale (GUSTO = Global Utilization of Streptokinase and Tissue plasminogen activator for Occluded coronary arteries). GUSTO Severe bleeding is defined as any of the following: (1) fatal bleeding, (2) intracranial bleeding, or (3) bleeding that caused haemodynamic compromise requiring intervention. GUSTO Moderate bleeding is a bleeding requiring transfusion of whole blood or packed red blood cells without haemodynamic compromise

Time Frame

From randomisation (day 1) to visit 3 (day 30-34)

Title

Premature Permanent Discontinuation of IP Due to Bleeding

Description

Participants with premature permanent discontinuation of IP due to bleeding

Time Frame

From randomisation (day 1) to visit 3 (day 30-34)

10. Eligibility

Sex

All

Minimum Age & Unit of Time

40 Years

Maximum Age & Unit of Time

130 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: Provision of signed informed consent prior to any study-specific procedure ≥40 years of age Acute onset of cerebral ischaemia due to AIS with NIHSS ≤5. AIS is defined as acute onset of neurological deficit attributed to focal brain ischaemia, and either of the following: Persistent signs or symptoms of the ischaemic event at the time o randomisation, OR Acute ischaemic brain lesion documented before randomisation by computed tomography (CT) scan or magnetic resonance imaging (MRI) (diffusion-weighted imaging) and that could account for the clinical presentation High-risk TIA, defined as neurological deficit of acute onset attributed to focal ischaemia of the brain by history or examination with complete resolution of the deficit, and at least one of the following: ABCD2 score ≥6 and TIA symptoms not limited to isolated numbness, isolated visual changes, or isolated dizziness/vertigo Symptomatic intracranial arterial occlusive disease that could account for the clinical presentation, documented by transcranial Doppler or vascular imaging and defined as at least 50% narrowing in the diameter of the vessel lumen Internal carotid arterial occlusive disease that could account for the clinical presentation, documented by Doppler, ultrasound, or vascular imaging and defined as at least 50% narrowing in diameter of the vessel lumen Randomisation occurring within 24 hours after onset of symptoms; for wake-up strokes (when the time of symptom onset is not known), within 24 hours from the time point at which the patient was reported to be in their normal condition CT or MRI performed after symptom onset ruling out intracranial haemorrhage or other pathology, such as vascular malformation, tumour, or abscess that according to the Investigator could explain symptoms or contraindicate study treatment Exclusion Criteria: Need for or an anticipated need for any of the following: Dual antiplatelet therapy with ASA and P2Y12 inhibitors (including patients with carotid artery stenting and percutaneous coronary intervention) Antiplatelets other than ASA (eg, GPIIb/IIIa inhibitors, clopidogrel, ticlopidine, prasugrel, dipyridamole, ozagrel, cilostazol, ticagrelor) and other antithrombotic agents with antiplatelet effects, including traditional/herbal medicine agents Anticoagulants (eg, warfarin, oral thrombin and factor Xa inhibitors, bivalirudin, hirudin, argatroban, fondaparinux, or unfractionated heparin and long-term treatment with low-molecular weight heparins). Short-term treatment (≤7 days) with low-dose low-molecular weight heparin may be used in immobilised patients at the discretion of the Investigator Any history of atrial fibrillation/flutter, ventricular aneurysm, or suspicion of other cardioembolic pathology for TIA or stroke Patients who should receive or have received any intravenous or intra-arterial thrombolysis or mechanical thrombectomy within 24 hours prior to randomisation Planned carotid endarterectomy that requires halting investigational product within 3 days of randomisation or is expected to require unblinding of investigational product (planned carotid endarterectomy is in itself not an exclusion criterion) History of previous intracranial haemorrhage at any time (asymptomatic microbleeds do not qualify), gastrointestinal haemorrhage within the past 6 months, or major surgery within 30 days Patients considered to be at risk of bradycardic events (eg, known sick sinus syndrome or second- or third-degree atrioventricular block) unless already treated with a permanent pacemaker Inability of the patient to understand and/or comply with study procedures and/or follow-up, in the opinion of the Investigator Known hypersensitivity to ticagrelor or ASA Need for or an anticipated need for oral or intravenous therapy with any of the following: Strong cytochrome P450 3A (CYP3A4) inhibitors (eg, ketoconazole, clarithromycin [but not erythromycin or azithromycin], nefazadone, ritonavir, atazanavir) that cannot be stopped for the course of the study Long-term (>7 days) non-steroidal anti-inflammatory drugs Known bleeding diathesis or coagulation disorder (eg, thrombotic thrombocytopenic purpura) Known severe liver disease (eg, ascites or signs of coagulopathy) Renal failure requiring dialysis Pregnancy or breastfeeding. Women of child-bearing potential who are not willing to use a medically accepted method of contraception that is considered reliable in the judgment of the Investigator Involvement in the planning and/or conduct of the study (applies to both AstraZeneca staff and/or staff at the study site) Previous enrolment or randomisation in the present study Participation in another clinical study with an investigational product at any time during the 30 days prior to randomisation (regardless of when treatment with the investigational product was discontinued)

Facility Information:

Facility Name

Research Site

City

Adrogué

ZIP/Postal Code

1846

Country

Argentina

Facility Name

Research Site

City

Buenos Aires

ZIP/Postal Code

1180AAX

Country

Argentina

Facility Name

Research Site

City

Buenos Aires

ZIP/Postal Code

1437

Country

Argentina

Facility Name

Research Site

City

Buenos Aires

ZIP/Postal Code

AR-CP 1221

Country

Argentina

Facility Name

Research Site

City

Buenos Aires

ZIP/Postal Code

C1425 FSD

Country

Argentina

Facility Name

Research Site

City

Buenos Aires

ZIP/Postal Code

C1437BZK

Country

Argentina

Facility Name

Research Site

City

Capital Federal

ZIP/Postal Code

1428

Country

Argentina

Facility Name

Research Site

City

Ciudad Autónoma de Bs. As.

ZIP/Postal Code

C1199ABB

Country

Argentina

Facility Name

Research Site

City

Cordoba

ZIP/Postal Code

5000

Country

Argentina

Facility Name

Research Site

City

Mar del Plata

ZIP/Postal Code

B7602CBM

Country

Argentina

Facility Name

Research Site

City

Mendoza

ZIP/Postal Code

M5500IDN

Country

Argentina

Facility Name

Research Site

City

Rosario

ZIP/Postal Code

S2000DSV

Country

Argentina

Facility Name

Research Site

City

Rosario

ZIP/Postal Code

S200GAP

Country

Argentina

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Research Site

City

Salta

ZIP/Postal Code

A4400

Country

Argentina

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Research Site

City

Adelaide

ZIP/Postal Code

5000

Country

Australia

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Research Site

City

Heidelberg

ZIP/Postal Code

3084

Country

Australia

Facility Name

Research Site

City

Herston

ZIP/Postal Code

4029

Country

Australia

Facility Name

Research Site

City

Parkville

ZIP/Postal Code

3050

Country

Australia

Facility Name

Research Site

City

Southport

ZIP/Postal Code

4215

Country

Australia

Facility Name

Research Site

City

St Albans

ZIP/Postal Code

3021

Country

Australia

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City

Antwerpen

ZIP/Postal Code

2020

Country

Belgium

Facility Name

Research Site

City

Assebroek (Brugge)

ZIP/Postal Code

8310

Country

Belgium

Facility Name

Research Site

City

Bruges

ZIP/Postal Code

8000

Country

Belgium

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Brussels

ZIP/Postal Code

1200

Country

Belgium

Facility Name

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City

Dendermonde

ZIP/Postal Code

9200

Country

Belgium

Facility Name

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City

Edegem

ZIP/Postal Code

2650

Country

Belgium

Facility Name

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City

Kortrijk

ZIP/Postal Code

8500

Country

Belgium

Facility Name

Research Site

City

Leuven

ZIP/Postal Code

3000

Country

Belgium

Facility Name

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City

Liège

ZIP/Postal Code

4000

Country

Belgium

Facility Name

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City

Oostende

ZIP/Postal Code

8400

Country

Belgium

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City

Roeselare

ZIP/Postal Code

8800

Country

Belgium

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City

Sint-Truiden

ZIP/Postal Code

3800

Country

Belgium

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City

Yvoir

ZIP/Postal Code

5530

Country

Belgium

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City

Botucatu

ZIP/Postal Code

18618-687

Country

Brazil

Facility Name

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City

Curitiba

ZIP/Postal Code

81210-310

Country

Brazil

Facility Name

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City

Goiania

ZIP/Postal Code

74083-100

Country

Brazil

Facility Name

Research Site

City

Joinville

ZIP/Postal Code

89202-165

Country

Brazil

Facility Name

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City

Maringa

ZIP/Postal Code

87015-000

Country

Brazil

Facility Name

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City

Porto Alegre

ZIP/Postal Code

90610-000

Country

Brazil

Facility Name

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City

Ribeirao Preto

ZIP/Postal Code

14015130

Country

Brazil

Facility Name

Research Site

City

Rio de Janeiro

ZIP/Postal Code

22270-005

Country

Brazil

Facility Name

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City

Salvador

ZIP/Postal Code

41820011

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Brazil

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City

Dupnitsa

ZIP/Postal Code

2600

Country

Bulgaria

Facility Name

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City

Kozloduy

ZIP/Postal Code

3320

Country

Bulgaria

Facility Name

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City

Lukovit

ZIP/Postal Code

5770

Country

Bulgaria

Facility Name

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City

Pazardzhik

ZIP/Postal Code

4400

Country

Bulgaria

Facility Name

Research Site

City

Pleven

ZIP/Postal Code

5800

Country

Bulgaria

Facility Name

Research Site

City

Sliven

ZIP/Postal Code

8800

Country

Bulgaria

Facility Name

Research Site

City

Sofia

ZIP/Postal Code

1142

Country

Bulgaria

Facility Name

Research Site

City

Sofia

ZIP/Postal Code

1407

Country

Bulgaria

Facility Name

Research Site

City

Sofia

ZIP/Postal Code

1606

Country

Bulgaria

Facility Name

Research Site

City

Teteven

ZIP/Postal Code

5700

Country

Bulgaria

Facility Name

Research Site

City

Calgary

State/Province

Alberta

ZIP/Postal Code

T2N 2T9

Country

Canada

Facility Name

Research Site

City

Edmonton

State/Province

Alberta

ZIP/Postal Code

T6G 2B7

Country

Canada

Facility Name

Research Site

City

Lethbridge

State/Province

Alberta

ZIP/Postal Code

T1J 0N9

Country

Canada

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Research Site

City

Chicoutimi

ZIP/Postal Code

G7H 5H6

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Canada

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City

Baoji

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721008

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China

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City

Baotou

ZIP/Postal Code

014016

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China

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Research Site

City

Beijing

ZIP/Postal Code

100049

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China

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Research Site

City

Beijing

ZIP/Postal Code

100070

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China

Facility Name

Research Site

City

Beijing

ZIP/Postal Code

100191

Country

China

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Research Site

City

Changsha

ZIP/Postal Code

410013

Country

China

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City

Changsha

ZIP/Postal Code

410078

Country

China

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City

Changsha

ZIP/Postal Code

430033

Country

China

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City

Chifeng

ZIP/Postal Code

024000

Country

China

Facility Name

Research Site

City

Daqing

ZIP/Postal Code

163000

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China

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Research Site

City

Foshan

ZIP/Postal Code

528000

Country

China

Facility Name

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City

Guangzhou

ZIP/Postal Code

510080

Country

China

Facility Name

Research Site

City

Guangzhou

ZIP/Postal Code

510180

Country

China

Facility Name

Research Site

City

Guangzhou

ZIP/Postal Code

510630

Country

China

Facility Name

Research Site

City

Guiyang

ZIP/Postal Code

550004

Country

China

Facility Name

Research Site

City

Haikou

ZIP/Postal Code

570311

Country

China

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City

Hangzhou

ZIP/Postal Code

310009

Country

China

Facility Name

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City

Hohhot

ZIP/Postal Code

010017

Country

China

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City

Hohhot

ZIP/Postal Code

10050

Country

China

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City

Jinan

ZIP/Postal Code

250001

Country

China

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City

Jinzhou

ZIP/Postal Code

121004

Country

China

Facility Name

Research Site

City

Liuzhou

ZIP/Postal Code

545006

Country

China

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Research Site

City

Nanchang

ZIP/Postal Code

330006

Country

China

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City

Nanjing

ZIP/Postal Code

210029

Country

China

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City

Nantong

ZIP/Postal Code

226001

Country

China

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City

Ningbo

ZIP/Postal Code

315010

Country

China

Facility Name

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City

Shanghai

ZIP/Postal Code

200080

Country

China

Facility Name

Research Site

City

Shanghai

ZIP/Postal Code

200090

Country

China

Facility Name

Research Site

City

Shanghai

ZIP/Postal Code

CN-200120

Country

China

Facility Name

Research Site

City

Shenyang

ZIP/Postal Code

110016

Country

China

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City

Taiyuan

ZIP/Postal Code

030001

Country

China

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City

Tangshan

ZIP/Postal Code

063001

Country

China

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City

Tianjin

ZIP/Postal Code

300060

Country

China

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Research Site

City

Tianjin

ZIP/Postal Code

300121

Country

China

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Research Site

City

Wenzhou

ZIP/Postal Code

325000

Country

China

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Research Site

City

Wu Han

ZIP/Postal Code

430060

Country

China

Facility Name

Research Site

City

Wuhan

ZIP/Postal Code

430022

Country

China

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Research Site

City

Wuhan

ZIP/Postal Code

430033

Country

China

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City

Wuxi

ZIP/Postal Code

214002

Country

China

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City

Xi'an

ZIP/Postal Code

710061

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China

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City

Xiamen

ZIP/Postal Code

361004

Country

China

Facility Name

Research Site

City

Xining

ZIP/Postal Code

810001

Country

China

Facility Name

Research Site

City

Xuzhou

ZIP/Postal Code

221006

Country

China

Facility Name

Research Site

City

Brno

ZIP/Postal Code

656 91

Country

Czechia

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Research Site

City

Chomutov

ZIP/Postal Code

430 12

Country

Czechia

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Research Site

City

Ostrava

ZIP/Postal Code

703 84

Country

Czechia

Facility Name

Research Site

City

Ostrava

ZIP/Postal Code

708 52

Country

Czechia

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Research Site

City

Pardubice

ZIP/Postal Code

520 03

Country

Czechia

Facility Name

Research Site

City

Praha 4

ZIP/Postal Code

140 59

Country

Czechia

Facility Name

Research Site

City

Usti nad Labem

ZIP/Postal Code

401 13

Country

Czechia

Facility Name

Research Site

City

Bayonne

ZIP/Postal Code

64100

Country

France

Facility Name

Research Site

City

Besancon Cedex

ZIP/Postal Code

25030

Country

France

Facility Name

Research Site

City

Bordeaux Cedex

ZIP/Postal Code

33076

Country

France

Facility Name

Research Site

City

Bourg en Bresse

ZIP/Postal Code

01012

Country

France

Facility Name

Research Site

City

Brest Cedex 2

ZIP/Postal Code

29609

Country

France

Facility Name

Research Site

City

Caen

ZIP/Postal Code

14033

Country

France

Facility Name

Research Site

City

Corbeil Essonnes Cedex

ZIP/Postal Code

91106

Country

France

Facility Name

Research Site

City

Dijon

ZIP/Postal Code

21079

Country

France

Facility Name

Research Site

City

Le Chesnay Cedex

ZIP/Postal Code

78157

Country

France

Facility Name

Research Site

City

Lille

ZIP/Postal Code

59037

Country

France

Facility Name

Research Site

City

Metz

ZIP/Postal Code

57085

Country

France

Facility Name

Research Site

City

Montpellier Cedex 5

ZIP/Postal Code

34295

Country

France

Facility Name

Research Site

City

Nancy

ZIP/Postal Code

54035

Country

France

Facility Name

Research Site

City

NICE Cedex 01

ZIP/Postal Code

06001

Country

France

Facility Name

Research Site

City

PARIS Cedex 12

ZIP/Postal Code

75571

Country

France

Facility Name

Research Site

City

Paris Cedex 13

ZIP/Postal Code

75651

Country

France

Facility Name

Research Site

City

Paris Cedex 18

ZIP/Postal Code

75877

Country

France

Facility Name

Research Site

City

Paris

ZIP/Postal Code

75019

Country

France

Facility Name

Research Site

City

Paris

ZIP/Postal Code

75475

Country

France

Facility Name

Research Site

City

Rennes

ZIP/Postal Code

35033

Country

France

Facility Name

Research Site

City

Rouen Cedex

ZIP/Postal Code

76031

Country

France

Facility Name

Research Site

City

Saint Herblain

ZIP/Postal Code

44093

Country

France

Facility Name

Research Site

City

Saint-Priez En Jarez

ZIP/Postal Code

42270

Country

France

Facility Name

Research Site

City

Strasbourg Cedex

ZIP/Postal Code

67098

Country

France

Facility Name

Research Site

City

Suresnes Cedex

ZIP/Postal Code

92151

Country

France

Facility Name

Research Site

City

Toulouse Cedex 9

ZIP/Postal Code

31059

Country

France

Facility Name

Research Site

City

Altenburg

ZIP/Postal Code

04600

Country

Germany

Facility Name

Research Site

City

Bad Neustadt

ZIP/Postal Code

97616

Country

Germany

Facility Name

Research Site

City

Berlin

ZIP/Postal Code

12351

Country

Germany

Facility Name

Research Site

City

Erlangen

ZIP/Postal Code

91054

Country

Germany

Facility Name

Research Site

City

Essen

ZIP/Postal Code

45147

Country

Germany

Facility Name

Research Site

City

Hamburg

ZIP/Postal Code

20099

Country

Germany

Facility Name

Research Site

City

Hamburg

ZIP/Postal Code

22043

Country

Germany

Facility Name

Research Site

City

Hamburg

ZIP/Postal Code

22291

Country

Germany

Facility Name

Research Site

City

Hamburg

ZIP/Postal Code

22763

Country

Germany

Facility Name

Research Site

City

Hannover

ZIP/Postal Code

30625

Country

Germany

Facility Name

Research Site

City

Minden

ZIP/Postal Code

32429

Country

Germany

Facility Name

Research Site

City

Münster

ZIP/Postal Code

48149

Country

Germany

Facility Name

Research Site

City

Hong Kong

Country

Hong Kong

Facility Name

Research Site

City

Kowloon

Country

Hong Kong

Facility Name

Research Site

City

Baja

ZIP/Postal Code

6500

Country

Hungary

Facility Name

Research Site

City

Balassagyarmat

ZIP/Postal Code

2660

Country

Hungary

Facility Name

Research Site

City

Budapest

ZIP/Postal Code

1083

Country

Hungary

Facility Name

Research Site

City

Budapest

ZIP/Postal Code

1106

Country

Hungary

Facility Name

Research Site

City

Budapest

ZIP/Postal Code

1125

Country

Hungary

Facility Name

Research Site

City

Budapest

ZIP/Postal Code

1134

Country

Hungary

Facility Name

Research Site

City

Budapest

ZIP/Postal Code

1204

Country

Hungary

Facility Name

Research Site

City

Debrecen

ZIP/Postal Code

4043

Country

Hungary

Facility Name

Research Site

City

Győr

ZIP/Postal Code

9000

Country

Hungary

Facility Name

Research Site

City

Kistarcsa

ZIP/Postal Code

2143

Country

Hungary

Facility Name

Research Site

City

Miskolc

ZIP/Postal Code

3526

Country

Hungary

Facility Name

Research Site

City

Nyíregyháza

ZIP/Postal Code

4400

Country

Hungary

Facility Name

Research Site

City

Pécs

ZIP/Postal Code

7623

Country

Hungary

Facility Name

Research Site

City

Sopron-Balf

ZIP/Postal Code

9494

Country

Hungary

Facility Name

Research Site

City

Székesfehérvár

ZIP/Postal Code

8000

Country

Hungary

Facility Name

Research Site

City

Tatabánya

ZIP/Postal Code

2800

Country

Hungary

Facility Name

Research Site

City

Bangalore

ZIP/Postal Code

560002

Country

India

Facility Name

Research Site

City

Bangalore

ZIP/Postal Code

560068

Country

India

Facility Name

Research Site

City

Bengaluru

ZIP/Postal Code

560076

Country

India

Facility Name

Research Site

City

Dehradun

ZIP/Postal Code

248001

Country

India

Facility Name

Research Site

City

Guntur

ZIP/Postal Code

522001

Country

India

Facility Name

Research Site

City

Gurgaon

ZIP/Postal Code

122001

Country

India

Facility Name

Research Site

City

Gurgaon

ZIP/Postal Code

122002

Country

India

Facility Name

Research Site

City

Hyderabad

ZIP/Postal Code

500018

Country

India

Facility Name

Research Site

City

Kanpur

ZIP/Postal Code

208002

Country

India

Facility Name

Research Site

City

Kolkata

ZIP/Postal Code

700017

Country

India

Facility Name

Research Site

City

Mangalore

ZIP/Postal Code

575002

Country

India

Facility Name

Research Site

City

Nagpur

ZIP/Postal Code

420012

Country

India

Facility Name

Research Site

City

Nagpur

ZIP/Postal Code

440012

Country

India

Facility Name

Research Site

City

Nashik

ZIP/Postal Code

422005

Country

India

Facility Name

Research Site

City

New Delhi

ZIP/Postal Code

110005

Country

India

Facility Name

Research Site

City

New Delhi

ZIP/Postal Code

110026

Country

India

Facility Name

Research Site

City

New Delhi

ZIP/Postal Code

110029

Country

India

Facility Name

Research Site

City

Srikakulam

ZIP/Postal Code

532001

Country

India

Facility Name

Research Site

City

Varanasi

ZIP/Postal Code

221004

Country

India

Facility Name

Research Site

City

Cona

ZIP/Postal Code

44124

Country

Italy

Facility Name

Research Site

City

Genova

ZIP/Postal Code

16128

Country

Italy

Facility Name

Research Site

City

Genova

ZIP/Postal Code

16132

Country

Italy

Facility Name

Research Site

City

Massa

ZIP/Postal Code

55100

Country

Italy

Facility Name

Research Site

City

Milano

ZIP/Postal Code

20132

Country

Italy

Facility Name

Research Site

City

Modena

ZIP/Postal Code

41100

Country

Italy

Facility Name

Research Site

City

Negrar

ZIP/Postal Code

37024

Country

Italy

Facility Name

Research Site

City

Pavia

ZIP/Postal Code

27100

Country

Italy

Facility Name

Research Site

City

Perugia

ZIP/Postal Code

06132

Country

Italy

Facility Name

Research Site

City

Pietra Ligure

ZIP/Postal Code

17027

Country

Italy

Facility Name

Research Site

City

Pisa

ZIP/Postal Code

56100

Country

Italy

Facility Name

Research Site

City

Roma

ZIP/Postal Code

00144

Country

Italy

Facility Name

Research Site

City

Roma

ZIP/Postal Code

00152

Country

Italy

Facility Name

Research Site

City

Roma

ZIP/Postal Code

00161

Country

Italy

Facility Name

Research Site

City

Siena

ZIP/Postal Code

53100

Country

Italy

Facility Name

Research Site

City

Varese

ZIP/Postal Code

21100

Country

Italy

Facility Name

Research Site

City

Verona

ZIP/Postal Code

37126

Country

Italy

Facility Name

Research Site

City

Vicenza

ZIP/Postal Code

36100

Country

Italy

Facility Name

Research Site

City

Vizzolo Predabissi

ZIP/Postal Code

20070

Country

Italy

Facility Name

Research Site

City

Anyang-si

ZIP/Postal Code

14068

Country

Korea, Republic of

Facility Name

Research Site

City

Busan

ZIP/Postal Code

49201

Country

Korea, Republic of

Facility Name

Research Site

City

Busan

ZIP/Postal Code

49241

Country

Korea, Republic of

Facility Name

Research Site

City

Cheongju-si

ZIP/Postal Code

28644

Country

Korea, Republic of

Facility Name

Research Site

City

Daegu

ZIP/Postal Code

42415

Country

Korea, Republic of

Facility Name

Research Site

City

Daegu

ZIP/Postal Code

42601

Country

Korea, Republic of

Facility Name

Research Site

City

Daegu

ZIP/Postal Code

700-721

Country

Korea, Republic of

Facility Name

Research Site

City

Daejeon-si

ZIP/Postal Code

35233

Country

Korea, Republic of

Facility Name

Research Site

City

Goyang-si

ZIP/Postal Code

411-706

Country

Korea, Republic of

Facility Name

Research Site

City

Gwangju

ZIP/Postal Code

61469

Country

Korea, Republic of

Facility Name

Research Site

City

Incheon

ZIP/Postal Code

400-711

Country

Korea, Republic of

Facility Name

Research Site

City

Jeju-do

ZIP/Postal Code

63241

Country

Korea, Republic of

Facility Name

Research Site

City

Seongnam-si

ZIP/Postal Code

13620

Country

Korea, Republic of

Facility Name

Research Site

City

Seoul

ZIP/Postal Code

01830

Country

Korea, Republic of

Facility Name

Research Site

City

Seoul

ZIP/Postal Code

02053

Country

Korea, Republic of

Facility Name

Research Site

City

Seoul

ZIP/Postal Code

02447

Country

Korea, Republic of

Facility Name

Research Site

City

Seoul

ZIP/Postal Code

04401

Country

Korea, Republic of

Facility Name

Research Site

City

Culiacan

ZIP/Postal Code

80230

Country

Mexico

Facility Name

Research Site

City

D.F

ZIP/Postal Code

14269

Country

Mexico

Facility Name

Research Site

City

Durango

ZIP/Postal Code

34217

Country

Mexico

Facility Name

Research Site

City

Guadalajara

ZIP/Postal Code

44280

Country

Mexico

Facility Name

Research Site

City

Mexico City

ZIP/Postal Code

07760

Country

Mexico

Facility Name

Research Site

City

Mexico City

ZIP/Postal Code

6726

Country

Mexico

Facility Name

Research Site

City

Mexico

ZIP/Postal Code

01090

Country

Mexico

Facility Name

Research Site

City

Monterrey

ZIP/Postal Code

64460

Country

Mexico

Facility Name

Research Site

City

México

ZIP/Postal Code

03103

Country

Mexico

Facility Name

Research Site

City

Tijuana

ZIP/Postal Code

22321

Country

Mexico

Facility Name

Research Site

City

Bellavista

ZIP/Postal Code

CALLAO 2

Country

Peru

Facility Name

Research Site

City

Callao

ZIP/Postal Code

CALLAO 02

Country

Peru

Facility Name

Research Site

City

Lima

ZIP/Postal Code

LIMA 01

Country

Peru

Facility Name

Research Site

City

Lima

ZIP/Postal Code

LIMA 13

Country

Peru

Facility Name

Research Site

City

Lima

ZIP/Postal Code

LIMA 1

Country

Peru

Facility Name

Research Site

City

Lima

ZIP/Postal Code

LIMA 31

Country

Peru

Facility Name

Research Site

City

Lima

ZIP/Postal Code

Lima-1

Country

Peru

Facility Name

Research Site

City

Trujillo

ZIP/Postal Code

130101

Country

Peru

Facility Name

Research Site

City

Urb. El Chipe

ZIP/Postal Code

20007

Country

Peru

Facility Name

Research Site

City

Białystok

ZIP/Postal Code

15-276

Country

Poland

Facility Name

Research Site

City

Chełm

ZIP/Postal Code

22-100

Country

Poland

Facility Name

Research Site

City

Działdowo

ZIP/Postal Code

13-200

Country

Poland

Facility Name

Research Site

City

Gdańsk

ZIP/Postal Code

80-803

Country

Poland

Facility Name

Research Site

City

Gdańsk

ZIP/Postal Code

80-952

Country

Poland

Facility Name

Research Site

City

Grodzisk Mazowiecki

ZIP/Postal Code

05-825

Country

Poland

Facility Name

Research Site

City

Gryfice

ZIP/Postal Code

72-300

Country

Poland

Facility Name

Research Site

City

Katowice

ZIP/Postal Code

40-635

Country

Poland

Facility Name

Research Site

City

Końskie

ZIP/Postal Code

26-200

Country

Poland

Facility Name

Research Site

City

Kraków

ZIP/Postal Code

31-826

Country

Poland

Facility Name

Research Site

City

Lublin

ZIP/Postal Code

20-954

Country

Poland

Facility Name

Research Site

City

Olsztyn

ZIP/Postal Code

10-082

Country

Poland

Facility Name

Research Site

City

Olsztyn

ZIP/Postal Code

10-560

Country

Poland

Facility Name

Research Site

City

Ostrołęka

ZIP/Postal Code

07-410

Country

Poland

Facility Name

Research Site

City

Rybnik

ZIP/Postal Code

44-200

Country

Poland

Facility Name

Research Site

City

Sandomierz

ZIP/Postal Code

27-600

Country

Poland

Facility Name

Research Site

City

Skarżysko-Kamienna

ZIP/Postal Code

26-110

Country

Poland

Facility Name

Research Site

City

Warszawa

ZIP/Postal Code

02-957

Country

Poland

Facility Name

Research Site

City

Warszawa

ZIP/Postal Code

03-242

Country

Poland

Facility Name

Research Site

City

Zielona Góra

ZIP/Postal Code

65-046

Country

Poland

Facility Name

Research Site

City

Łódź

ZIP/Postal Code

90-153

Country

Poland

Facility Name

Research Site

City

Łódź

ZIP/Postal Code

93-113

Country

Poland

Facility Name

Research Site

City

Świebodzin

ZIP/Postal Code

66-200

Country

Poland

Facility Name

Research Site

City

Bucharest

ZIP/Postal Code

011461

Country

Romania

Facility Name

Research Site

City

Bucharest

ZIP/Postal Code

020125

Country

Romania

Facility Name

Research Site

City

Bucharest

ZIP/Postal Code

050098

Country

Romania

Facility Name

Research Site

City

Iasi

ZIP/Postal Code

700309

Country

Romania

Facility Name

Research Site

City

Oradea

ZIP/Postal Code

410169

Country

Romania

Facility Name

Research Site

City

Sibiu

ZIP/Postal Code

550166

Country

Romania

Facility Name

Research Site

City

Timisoara

ZIP/Postal Code

300736

Country

Romania

Facility Name

Research Site

City

Tirgu-Mures

ZIP/Postal Code

540136

Country

Romania

Facility Name

Research Site

City

Chelyabinsk

ZIP/Postal Code

454106

Country

Russian Federation

Facility Name

Research Site

City

Ekaterinburg

ZIP/Postal Code

620102

Country

Russian Federation

Facility Name

Research Site

City

Izhevsk

ZIP/Postal Code

426063

Country

Russian Federation

Facility Name

Research Site

City

Kazan

ZIP/Postal Code

420012

Country

Russian Federation

Facility Name

Research Site

City

Kazan

ZIP/Postal Code

420101

Country

Russian Federation

Facility Name

Research Site

City

Kemerovo

ZIP/Postal Code

650002

Country

Russian Federation

Facility Name

Research Site

City

Moscow

ZIP/Postal Code

109004

Country

Russian Federation

Facility Name

Research Site

City

Moscow

ZIP/Postal Code

115516

Country

Russian Federation

Facility Name

Research Site

City

Moscow

ZIP/Postal Code

117292

Country

Russian Federation

Facility Name

Research Site

City

Moscow

ZIP/Postal Code

117997

Country

Russian Federation

Facility Name

Research Site

City

Moscow

ZIP/Postal Code

121374

Country

Russian Federation

Facility Name

Research Site

City

Moscow

ZIP/Postal Code

123367

Country

Russian Federation

Facility Name

Research Site

City

Nizhnii Novgorod

ZIP/Postal Code

603018

Country

Russian Federation

Facility Name

Research Site

City

Nizhniy Novgorod

ZIP/Postal Code

603005

Country

Russian Federation

Facility Name

Research Site

City

Novosibirsk

ZIP/Postal Code

630003

Country

Russian Federation

Facility Name

Research Site

City

Novosibirsk

ZIP/Postal Code

630051

Country

Russian Federation

Facility Name

Research Site

City

Ryazan

ZIP/Postal Code

390039

Country

Russian Federation

Facility Name

Research Site

City

Saint Petersburg

ZIP/Postal Code

196247

Country

Russian Federation

Facility Name

Research Site

City

Saint Petersburg

ZIP/Postal Code

196601

Country

Russian Federation

Facility Name

Research Site

City

Saint-Petersburg

ZIP/Postal Code

192242

Country

Russian Federation

Facility Name

Research Site

City

Saint-Petersburg

ZIP/Postal Code

194354

Country

Russian Federation

Facility Name

Research Site

City

Samara

ZIP/Postal Code

443095

Country

Russian Federation

Facility Name

Research Site

City

Samara

ZIP/Postal Code

443096

Country

Russian Federation

Facility Name

Research Site

City

Saratov

ZIP/Postal Code

410030

Country

Russian Federation

Facility Name

Research Site

City

Sochi

ZIP/Postal Code

354057

Country

Russian Federation

Facility Name

Research Site

City

Tomsk

ZIP/Postal Code

634063

Country

Russian Federation

Facility Name

Research Site

City

Ufa

ZIP/Postal Code

450071

Country

Russian Federation

Facility Name

Research Site

City

Voronezh

ZIP/Postal Code

394066

Country

Russian Federation

Facility Name

Research Site

City

Yaroslavl

ZIP/Postal Code

150030

Country

Russian Federation

Facility Name

Research Site

City

Ar Riyāḑ

ZIP/Postal Code

11426

Country

Saudi Arabia

Facility Name

Research Site

City

Jeddah

ZIP/Postal Code

21423

Country

Saudi Arabia

Facility Name

Research Site

City

Riyadh

ZIP/Postal Code

11525

Country

Saudi Arabia

Facility Name

Research Site

City

Riyadh

ZIP/Postal Code

12372

Country

Saudi Arabia

Facility Name

Research Site

City

Dolny Kubin

ZIP/Postal Code

02614

Country

Slovakia

Facility Name

Research Site

City

Levoca

ZIP/Postal Code

054 01

Country

Slovakia

Facility Name

Research Site

City

Liptovsky Mikulas

ZIP/Postal Code

031 23

Country

Slovakia

Facility Name

Research Site

City

Martin

ZIP/Postal Code

03659

Country

Slovakia

Facility Name

Research Site

City

Nitra

ZIP/Postal Code

949 01

Country

Slovakia

Facility Name

Research Site

City

Rimavska Sobota

ZIP/Postal Code

97912

Country

Slovakia

Facility Name

Research Site

City

Skalica

ZIP/Postal Code

909 82

Country

Slovakia

Facility Name

Research Site

City

Spisska Nova Ves

ZIP/Postal Code

052 01

Country

Slovakia

Facility Name

Research Site

City

Trencin

ZIP/Postal Code

81171

Country

Slovakia

Facility Name

Research Site

City

Trnava

ZIP/Postal Code

91701

Country

Slovakia

Facility Name

Research Site

City

Ziar nad Hronom

ZIP/Postal Code

96537

Country

Slovakia

Facility Name

Research Site

City

Albacete

ZIP/Postal Code

02006

Country

Spain

Facility Name

Research Site

City

Alicante

ZIP/Postal Code

03010

Country

Spain

Facility Name

Research Site

City

Badalona(Barcelona)

ZIP/Postal Code

08916

Country

Spain

Facility Name

Research Site

City

Barcelona

ZIP/Postal Code

08003

Country

Spain

Facility Name

Research Site

City

Barcelona

ZIP/Postal Code

08025

Country

Spain

Facility Name

Research Site

City

Barcelona

ZIP/Postal Code

08035

Country

Spain

Facility Name

Research Site

City

Gerona

ZIP/Postal Code

17007

Country

Spain

Facility Name

Research Site

City

Lleida

ZIP/Postal Code

25198

Country

Spain

Facility Name

Research Site

City

Madrid

ZIP/Postal Code

28006

Country

Spain

Facility Name

Research Site

City

Madrid

ZIP/Postal Code

28034

Country

Spain

Facility Name

Research Site

City

Sevilla

ZIP/Postal Code

41009

Country

Spain

Facility Name

Research Site

City

Sevilla

ZIP/Postal Code

41013

Country

Spain

Facility Name

Research Site

City

Valencia

ZIP/Postal Code

46009

Country

Spain

Facility Name

Research Site

City

Valladolid

ZIP/Postal Code

47005

Country

Spain

Facility Name

Research Site

City

Zaragoza

ZIP/Postal Code

50009

Country

Spain

Facility Name

Research Site

City

Göteborg

ZIP/Postal Code

413 45

Country

Sweden

Facility Name

Research Site

City

Linköping

ZIP/Postal Code

581 85

Country

Sweden

Facility Name

Research Site

City

Lund

ZIP/Postal Code

221 85

Country

Sweden

Facility Name

Research Site

City

Malmö

ZIP/Postal Code

205 02

Country

Sweden

Facility Name

Research Site

City

Ostersund

ZIP/Postal Code

831 83

Country

Sweden

Facility Name

Research Site

City

Skövde

ZIP/Postal Code

541 85

Country

Sweden

Facility Name

Research Site

City

Solna

ZIP/Postal Code

171 76

Country

Sweden

Facility Name

Research Site

City

Stockholm

ZIP/Postal Code

118 83

Country

Sweden

Facility Name

Research Site

City

Stockholm

ZIP/Postal Code

182 88

Country

Sweden

Facility Name

Research Site

City

Uppsala

ZIP/Postal Code

751 85

Country

Sweden

Facility Name

Research Site

City

Changhua

ZIP/Postal Code

500

Country

Taiwan

Facility Name

Research Site

City

Kaohsiung City

ZIP/Postal Code

83301

Country

Taiwan

Facility Name

Research Site

City

Kaohsiung

ZIP/Postal Code

80756

Country

Taiwan

Facility Name

Research Site

City

Keelung

ZIP/Postal Code

20448

Country

Taiwan

Facility Name

Research Site

City

New Taipei City

ZIP/Postal Code

237

Country

Taiwan

Facility Name

Research Site

City

New Taipei

ZIP/Postal Code

23561

Country

Taiwan

Facility Name

Research Site

City

Taichung City

ZIP/Postal Code

437

Country

Taiwan

Facility Name

Research Site

City

Taichung

ZIP/Postal Code

40447

Country

Taiwan

Facility Name

Research Site

City

Taichung

ZIP/Postal Code

40705

Country

Taiwan

Facility Name

Research Site

City

Tainan

ZIP/Postal Code

704

Country

Taiwan

Facility Name

Research Site

City

Tainan

ZIP/Postal Code

710

Country

Taiwan

Facility Name

Research Site

City

Taipei

ZIP/Postal Code

10002

Country

Taiwan

Facility Name

Research Site

City

Taipei

ZIP/Postal Code

10449

Country

Taiwan

Facility Name

Research Site

City

Taipei

ZIP/Postal Code

11101

Country

Taiwan

Facility Name

Research Site

City

Taipei

ZIP/Postal Code

116

Country

Taiwan

Facility Name

Research Site

City

Taoyuan Hsien

ZIP/Postal Code

33305

Country

Taiwan

Facility Name

Research Site

City

Bangkok

ZIP/Postal Code

10220

Country

Thailand

Facility Name

Research Site

City

Bangkok

ZIP/Postal Code

10300

Country

Thailand

Facility Name

Research Site

City

Bangkok

ZIP/Postal Code

10330

Country

Thailand

Facility Name

Research Site

City

Bangkok

ZIP/Postal Code

10400

Country

Thailand

Facility Name

Research Site

City

Bangkok

ZIP/Postal Code

10600

Country

Thailand

Facility Name

Research Site

City

Bangkok

ZIP/Postal Code

10700

Country

Thailand

Facility Name

Research Site

City

Chonburi

ZIP/Postal Code

20000

Country

Thailand

Facility Name

Research Site

City

Hat Yai

ZIP/Postal Code

90110

Country

Thailand

Facility Name

Research Site

City

Khlong Luang

ZIP/Postal Code

12120

Country

Thailand

Facility Name

Research Site

City

Khon Kaen

ZIP/Postal Code

40002

Country

Thailand

Facility Name

Research Site

City

Lampang

ZIP/Postal Code

52000

Country

Thailand

Facility Name

Research Site

City

Muang

ZIP/Postal Code

57000

Country

Thailand

Facility Name

Research Site

City

Nakhonpathom

ZIP/Postal Code

73000

Country

Thailand

Facility Name

Research Site

City

Prachinburi

ZIP/Postal Code

25000

Country

Thailand

Facility Name

Research Site

City

Rajthevi

ZIP/Postal Code

10400

Country

Thailand

Facility Name

Research Site

City

Ratchaburi

ZIP/Postal Code

70000

Country

Thailand

Facility Name

Research Site

City

Ubonratchathani

ZIP/Postal Code

34000

Country

Thailand

Facility Name

Research Site

City

Chernivtsі

ZIP/Postal Code

58001

Country

Ukraine

Facility Name

Research Site

City

Ivano-Frankivsk

ZIP/Postal Code

76008

Country

Ukraine

Facility Name

Research Site

City

Ivano-Frankivsk

ZIP/Postal Code

76018

Country

Ukraine

Facility Name

Research Site

City

Kharkiv Region

ZIP/Postal Code

61018

Country

Ukraine

Facility Name

Research Site

City

Kharkiv Region

ZIP/Postal Code

61176

Country

Ukraine

Facility Name

Research Site

City

Kherson

ZIP/Postal Code

73000

Country

Ukraine

Facility Name

Research Site

City

Kyiv

ZIP/Postal Code

03129

Country

Ukraine

Facility Name

Research Site

City

Lutsk

ZIP/Postal Code

43024

Country

Ukraine

Facility Name

Research Site

City

Lviv

ZIP/Postal Code

79013

Country

Ukraine

Facility Name

Research Site

City

Poltava

ZIP/Postal Code

36038

Country

Ukraine

Facility Name

Research Site

City

Ternopil

ZIP/Postal Code

46027

Country

Ukraine

Facility Name

Research Site

City

Vinnytsia

ZIP/Postal Code

21005

Country

Ukraine

Facility Name

Research Site

City

Zaporizhzhia

ZIP/Postal Code

69068

Country

Ukraine

Facility Name

Research Site

City

Zaporizhzhia

ZIP/Postal Code

69600

Country

Ukraine

Facility Name

Research Site

City

Dong Nai

ZIP/Postal Code

81000

Country

Vietnam

Facility Name

Research Site

City

Ha Noi

ZIP/Postal Code

10000

Country

Vietnam

Facility Name

Research Site

City

Hanoi

ZIP/Postal Code

10000

Country

Vietnam

Facility Name

Research Site

City

Ho Chi Minh City

ZIP/Postal Code

70000

Country

Vietnam

Facility Name

Research Site

City

Ho Chi Minh

ZIP/Postal Code

70000

Country

Vietnam

12. IPD Sharing Statement

Citations:

PubMed Identifier

34477459

Citation

Johnston SC, Amarenco P, Aunes M, Denison H, Evans SR, Himmelmann A, Jahreskog M, James S, Knutsson M, Ladenvall P, Molina CA, Nylander S, Rother J, Wang Y; THALES Investigators. Ischemic Benefit and Hemorrhage Risk of Ticagrelor-Aspirin Versus Aspirin in Patients With Acute Ischemic Stroke or Transient Ischemic Attack. Stroke. 2021 Nov;52(11):3482-3489. doi: 10.1161/STROKEAHA.121.035555. Epub 2021 Sep 3.

Results Reference

derived

PubMed Identifier

34244703

Citation

Wang Y, Pan Y, Li H, Amarenco P, Denison H, Evans SR, Himmelmann A, James S, Birve F, Ladenvall P, Molina CA, Johnston SC; THALES Steering Committee and Investigators. Efficacy and Safety of Ticagrelor and Aspirin in Patients With Moderate Ischemic Stroke: An Exploratory Analysis of the THALES Randomized Clinical Trial. JAMA Neurol. 2021 Sep 1;78(9):1091-1098. doi: 10.1001/jamaneurol.2021.2440.

Results Reference

derived

PubMed Identifier

33940954

Citation

Yaghi S, de Havenon A, Rostanski S, Kvernland A, Mac Grory B, Furie KL, Kim AS, Easton JD, Johnston SC, Henninger N. Carotid Stenosis and Recurrent Ischemic Stroke: A Post-Hoc Analysis of the POINT Trial. Stroke. 2021 Jul;52(7):2414-2417. doi: 10.1161/STROKEAHA.121.034089. Epub 2021 May 4.

Results Reference

derived

PubMed Identifier

33198608

Citation

Amarenco P, Denison H, Evans SR, Himmelmann A, James S, Knutsson M, Ladenvall P, Molina CA, Wang Y, Johnston SC; THALES Steering Committee and Investigators*. Ticagrelor Added to Aspirin in Acute Nonsevere Ischemic Stroke or Transient Ischemic Attack of Atherosclerotic Origin. Stroke. 2020 Dec;51(12):3504-3513. doi: 10.1161/STROKEAHA.120.032239. Epub 2020 Nov 16.

Results Reference

derived

PubMed Identifier

33159526

Citation

Amarenco P, Denison H, Evans SR, Himmelmann A, James S, Knutsson M, Ladenvall P, Molina CA, Wang Y, Johnston SC; THALES Steering Committee and Investigators. Ticagrelor Added to Aspirin in Acute Ischemic Stroke or Transient Ischemic Attack in Prevention of Disabling Stroke: A Randomized Clinical Trial. JAMA Neurol. 2020 Nov 7;78(2):1-9. doi: 10.1001/jamaneurol.2020.4396. Online ahead of print. Erratum In: JAMA Neurol. 2021 Feb 1;78(2):253.

Results Reference

derived

PubMed Identifier

32668111

Citation

Johnston SC, Amarenco P, Denison H, Evans SR, Himmelmann A, James S, Knutsson M, Ladenvall P, Molina CA, Wang Y; THALES Investigators. Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA. N Engl J Med. 2020 Jul 16;383(3):207-217. doi: 10.1056/NEJMoa1916870.

Results Reference

derived

PubMed Identifier

30747613

Citation

Johnston SC, Amarenco P, Denison H, Evans SR, Himmelmann A, James S, Knutsson M, Ladenvall P, Molina CA, Wang Y; THALES Investigators. The Acute Stroke or Transient Ischemic Attack Treated with Ticagrelor and Aspirin for Prevention of Stroke and Death (THALES) trial: Rationale and design. Int J Stroke. 2019 Oct;14(7):745-751. doi: 10.1177/1747493019830307. Epub 2019 Feb 12.

Results Reference

derived

PubMed Identifier

29915123

Citation

Wong KSL, Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Himmelmann A, Kasner SE, Knutsson M, Ladenvall P, Minematsu K, Molina CA, Wang Y, Johnston SC; SOCRATES Steering Committee and Investigators. Efficacy and Safety of Ticagrelor in Relation to Aspirin Use Within the Week Before Randomization in the SOCRATES Trial. Stroke. 2018 Jul;49(7):1678-1685. doi: 10.1161/STROKEAHA.118.020553. Epub 2018 Jun 18.

Results Reference

derived

Links:

URL

https://filehosting-v2.pharmacm.com/api/Attachment/Download?tenantId=80217111&parentIdentifier=D5134C00003&attachmentIdentifier=3c773278-ed11-4f6a-ba36-6d927f39a776&fileName=d5134c00003_SAP_redacted.pdf&versionIdentifier=

Description

redacted SAP

URL

https://filehosting-v2.pharmacm.com/api/Attachment/Download?tenantId=80217111&parentIdentifier=D5134C00003&attachmentIdentifier=52098dc2-641a-49a8-8478-d745f5a10a26&fileName=d5134c00003_CSP_redacted.pdf&versionIdentifier=

Description

redacted CSP

Learn more about this trial

THALES - Acute STroke or Transient IscHaemic Attack Treated With TicAgreLor and ASA for PrEvention of Stroke and Death

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THALES - Acute STroke or Transient IscHaemic Attack Treated With TicAgreLor and ASA for PrEvention of Stroke and Death (THALES)

Acute Ischaemic Stroke, Transient Ischaemic Attack

About this trial

Eligibility Criteria

Sites / Locations

Arms of the Study

Arm 1

Arm 2

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

1. Study Identification

2. Study Status

3. Sponsor/Collaborators

4. Oversight

5. Study Description

6. Conditions and Keywords

7. Study Design

8. Arms, Groups, and Interventions

10. Eligibility

12. IPD Sharing Statement

Learn more about this trial