Back to resultsDyslexia, Motor Control and Proprioception
Primary Purpose
Dyslexia
Status
Terminated
Phase
Not Applicable
Locations
France
Study Type
Interventional
Intervention
Evaluation of proprioception
Evaluation of motor learning
Evaluation of written language
Sponsored by
About this trial
This is an interventional basic science trial for Dyslexia focused on measuring Motor control, Proprioception
Eligibility Criteria
Inclusion criteria for all children
- Child with a French social security
- School child
- Native French speaker
- right-handed
- Normal or corrected vision
- Without neurological or psychiatric histories
- Agree to participate in the study in agreement with parental rights representatives
For the dyslexic group :
- pluridisciplinary diagnostic
- never consulted for proprioception before
- without any other leaning disorders like dysphasia
- attention deficit hyperactivity disorder (ADHD) or developmental coordination disorder (DCD)
For the control group :
- regular school attendance
- never consulted for learning disabilities
- No learning disorders known for their parents or siblings.
Exclusion criteria for all children
- genetic disorder
- neurological or psychiatric history
- Delayed psychomotor development
- Reeducation or current treatment interfering with the evaluation
Sites / Locations
- Inserm U1093
Arms of the Study
Arm 1
Arm Type
Experimental
Arm Label
Dyslexic and non dyslexic Children
Arm Description
Children aged 10-12 Evaluation of proprioception Evaluation of motor learning Evaluation of written language
Outcomes
Primary Outcome Measures
Evaluation of proprioception through velocity perception
The ability to perceive motion at 3 different velocities for 3 different joints is assessed using a motorized ergometer. A passive movement is performed by the ergometer and children are tasked to press a button as soon as they feel the movement. We calculate the angle of detection for each speed and compare it between Dyslexic and healthy children.
Secondary Outcome Measures
Evaluation of proprioception through position perception
The ability to perceive position is assessed using an ergometer that produces passive movements of 3 different amplitudes on the dominant arm. In a second time, the ergometer produces a passive movement of the same arm and children are tasked to press a button as soon as they feel they are in the exact previously-experienced position. We calculate the angular error and compare it between Dyslexic and healthy children.
Motor learning
The ability to learn new motor tasks is assessed using virtual reality and motor acquisition systems. First we evaluate the motor accuracy and the state estimation by pointing tests. Then visual perturbations are introduced during pointing. Finally, we evaluate motor accuracy and state estimation again.
Text reading
The ability to read aloud a text is assessed using the French standardized test " Alouette ", which provide accuracy in reading aloud age-normed texts (ratio between words that have been correctly read and all the words that have been read).
Phonological awareness: phonemic blending and phonemic elision
The ability to derive a phonemic pattern from distinct phonemic units or to substitute a phonemic pattern for another is assessed using the French standardized test " Nepsy2, phonological process " which provide standard deviation in reading aloud by the investigator.
Identifying words
The ability to identify words is assessed using the French standardized test " Timé3 ", which provide lexical level and delay reading in silent reading age-normed words.
Full Information
NCT ID
NCT03364010
First Posted
September 27, 2017
Last Updated
February 17, 2023
Sponsor
Institut National de la Santé Et de la Recherche Médicale, France
1. Study Identification
Unique Protocol Identification Number
NCT03364010
Brief Title
Dyslexia, Motor Control and Proprioception
Official Title
Relationships Between Proprioception, Motor Control and Reading in Children With Dyslexia
Study Type
Interventional
2. Study Status
Record Verification Date
February 2023
Overall Recruitment Status
Terminated
Why Stopped
END OF INCLUSIONS
Study Start Date
January 4, 2018 (Actual)
Primary Completion Date
May 9, 2019 (Actual)
Study Completion Date
June 2, 2021 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Institut National de la Santé Et de la Recherche Médicale, France
4. Oversight
Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
The investigators hypothesize that children with dyslexia present proprioceptive disorders and the purpose of the present study is to better understand relationships between motor control, proprioception and academic learnings. The investigators compare a group of French students with and without dyslexia aged 10-12.
Detailed Description
2 groups of children (dyslexics and control) will be evaluated on 2 tasks:
Evaluation of the proprioception: Perception of the speed and Perception of the position
Evaluation of the motor learning: Estimation of state in the framework of a motor perturbation
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Dyslexia
Keywords
Motor control, Proprioception
7. Study Design
Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Single Group Assignment
Masking
None (Open Label)
Allocation
N/A
Enrollment
56 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Dyslexic and non dyslexic Children
Arm Type
Experimental
Arm Description
Children aged 10-12 Evaluation of proprioception Evaluation of motor learning Evaluation of written language
Intervention Type
Behavioral
Intervention Name(s)
Evaluation of proprioception
Intervention Description
Velocity perception and Position perception
Intervention Type
Behavioral
Intervention Name(s)
Evaluation of motor learning
Intervention Description
Motor accurancy and State Estimation with visual perturbations
Intervention Type
Behavioral
Intervention Name(s)
Evaluation of written language
Intervention Description
Text reading, Identifying words and Phonological awareness: phonemic blending and phonemic elision
Primary Outcome Measure Information:
Title
Evaluation of proprioception through velocity perception
Description
The ability to perceive motion at 3 different velocities for 3 different joints is assessed using a motorized ergometer. A passive movement is performed by the ergometer and children are tasked to press a button as soon as they feel the movement. We calculate the angle of detection for each speed and compare it between Dyslexic and healthy children.
Time Frame
1day
Secondary Outcome Measure Information:
Title
Evaluation of proprioception through position perception
Description
The ability to perceive position is assessed using an ergometer that produces passive movements of 3 different amplitudes on the dominant arm. In a second time, the ergometer produces a passive movement of the same arm and children are tasked to press a button as soon as they feel they are in the exact previously-experienced position. We calculate the angular error and compare it between Dyslexic and healthy children.
Time Frame
1 day
Title
Motor learning
Description
The ability to learn new motor tasks is assessed using virtual reality and motor acquisition systems. First we evaluate the motor accuracy and the state estimation by pointing tests. Then visual perturbations are introduced during pointing. Finally, we evaluate motor accuracy and state estimation again.
Time Frame
1 day
Title
Text reading
Description
The ability to read aloud a text is assessed using the French standardized test " Alouette ", which provide accuracy in reading aloud age-normed texts (ratio between words that have been correctly read and all the words that have been read).
Time Frame
1day
Title
Phonological awareness: phonemic blending and phonemic elision
Description
The ability to derive a phonemic pattern from distinct phonemic units or to substitute a phonemic pattern for another is assessed using the French standardized test " Nepsy2, phonological process " which provide standard deviation in reading aloud by the investigator.
Time Frame
1day
Title
Identifying words
Description
The ability to identify words is assessed using the French standardized test " Timé3 ", which provide lexical level and delay reading in silent reading age-normed words.
Time Frame
1day
10. Eligibility
Sex
All
Minimum Age & Unit of Time
10 Years
Maximum Age & Unit of Time
12 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion criteria for all children
Child with a French social security
School child
Native French speaker
right-handed
Normal or corrected vision
Without neurological or psychiatric histories
Agree to participate in the study in agreement with parental rights representatives
For the dyslexic group :
pluridisciplinary diagnostic
never consulted for proprioception before
without any other leaning disorders like dysphasia
attention deficit hyperactivity disorder (ADHD) or developmental coordination disorder (DCD)
For the control group :
regular school attendance
never consulted for learning disabilities
No learning disorders known for their parents or siblings.
Exclusion criteria for all children
genetic disorder
neurological or psychiatric history
Delayed psychomotor development
Reeducation or current treatment interfering with the evaluation
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Patrick QUERCIA, dr
Organizational Affiliation
Unité Inserm d'affiliation : Laboratoire U1093 Cognition, Action et Plasticité Sensorimotrice
Official's Role
Principal Investigator
Facility Information:
Facility Name
Inserm U1093
City
Dijon
State/Province
Bourgogne
ZIP/Postal Code
21000
Country
France
12. IPD Sharing Statement
Citations:
PubMed Identifier
33431949
Citation
Laprevotte J, Papaxanthis C, Saltarelli S, Quercia P, Gaveau J. Movement detection thresholds reveal proprioceptive impairments in developmental dyslexia. Sci Rep. 2021 Jan 11;11(1):299. doi: 10.1038/s41598-020-79612-4.
Results Reference
derived
Learn more about this trial
Dyslexia, Motor Control and Proprioception
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