Transcranial Electrical Stimulation for Cervical Dystonia
Primary Cervical Dystonia
About this trial
This is an interventional basic science trial for Primary Cervical Dystonia
Eligibility Criteria
Primary Cervical Dystonia
Inclusion Criteria:
- Right-handed
- On a stable dose of all medications used to treat dystonia for the month previous to enrollment
- No botox injections in the 10 weeks previous to enrollment
Exclusion Criteria:
- Any contraindication to MRI scanning, tES, or TMS (e.g pregnancy, history of seizures, significant systemic medical conditions, untreated psychiatric or neurological conditions)
- Evidence on neurological exam of any potentially confounding neurological disorder
- Evidence of significant cognitive impairment
- Patients with dystonia symptoms beginning prior to the age of 18 will be excluded
- Patients with secondary dystonia resulting from medications or that are part of another neurological disorder (e.g. Parkinson's disease) will be excluded
- Medication that might predispose the subject to seizures
Healthy Controls
Inclusion Criteria:
- Right-handed
Exclusion Criteria:
- Any contraindication to MRI scanning, tES, or TMS (e.g pregnancy, history of seizures, significant systemic medical conditions, untreated psychiatric or neurological conditions)
- Evidence on neurological exam of any potentially confounding neurological disorder
- Evidence of significant cognitive impairment
- Medication that might predispose the subject to seizures
Sites / Locations
- University of Colorado Denver
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Sham Comparator
MRI - HC tDCS
MRI - HC tACS
MRI - CD tCDS
MRI - CD tACS
Phase II - Stim
Phase II - Sham
Healthy controls in Phase 1 transcranial electrical stimulation set to direct current
Healthy controls in Phase 1- transcranial electrical stimulation set to alternating current
Cervical dystonia in Phase 1 transcranial electrical stimulation set to direct current
Cervical dystonia in Phase 1 transcranial electrical stimulation set to alternating current
Cervical dystonia in Phase 2 transcranial electrical stimulation setting is active
Cervical dystonia in Phase 2 transcranial electrical stimulation setting is sham