Effects of Psyllium on Niacin Tolerability
Flushing, Hyperlipidemias, Dyslipidemias
About this trial
This is an interventional supportive care trial for Flushing focused on measuring Niacin, Psyllium, Dietary fiber
Eligibility Criteria
Inclusion Criteria:
- Patients who are starting ER niacin for clinical indication by a healthcare provider
- No prior use of psyllium for the past 2 months
- No prior use of niacin for the past 3 months
- Ability to give informed consent
- Must be reachable by telephone
Exclusion Criteria:
- Known contraindications to ER niacin, aspirin or psyllium (including: presence of nausea, vomiting, abdominal pain, intestinal obstruction, or fecal impaction; known hypersensitivity to ER niacin, aspirin or psyllium; severe hepatic dysfunction, transaminitis; history of gastrointestinal bleed attributable to aspirin induced gastritis)
- Patient who are unable to perform assessment of flushing using the standardized scales or questionnaires
- Patients who are pregnant
Sites / Locations
- VA West Los Angeles Medical Center
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Psyllium plus Aspirin and Niacin ER
Aspirin and Niacin ER
Niacin ER 500mg tablet - take 1 niacin ER 500mg tablet at least two hours before bedtime for two weeks, then increase niacin ER to two 500mg tablets (1,000 mg total) for two weeks, then increase to three niacin ER 500mg tablets (1,500 mg total) for two weeks. Aspirin 325mg tablet - take 1 aspirin 325 mg tablet 30 minutes prior to niacin ER Psyllium 1.7gm wafers - take 2 wafers (3.4 grams total) along with aspirin 30 minutes prior to niacin ER
Niacin ER 500mg tablet - take 1 niacin ER 500mg tablet at least two hours before bedtime for two weeks, then increase niacin ER to two 500mg tablets (1,000 mg total) for two weeks, then increase to three niacin ER 500mg tablets (1,500 mg total) for two weeks. Aspirin 325mg tablet - take 1 aspirin 325 mg tablet 30 minutes prior to niacin ER