Different Radiation Dose of Neoadjuvant Chemoradiation for Resectable Thoracic Esophageal Squamous Carcinoma (Neo-DRATEC)
Esophageal Carcinoma, Neoadjuvant Chemoradiotherapy, Surgery
About this trial
This is an interventional treatment trial for Esophageal Carcinoma focused on measuring Radiation dose
Eligibility Criteria
Inclusion Criteria:
Age:18-70 years
Histologically verified squamous carcinoma of the thoracic esophagus.
Patients with performance status 0-1 according to the Eastern Cooperative Oncology Group (ECOG) scale at the pre CRT evaluation and judges to be fit for surgery at the pre and post CRT evaluations.
Tumors should be resectable or potentially resectable and without distant metastasis, as assessed before neoadjuvant CRT, including clinical stage T2-4N0M0 or T1-4N1M0 according to the 6th AJCC system.
Joined the study voluntarily and signed informed consent form
No surgical contraindications
No serious system dysfunction and immuno-deficiency, Adequate organ function including the following: Hemoglobin ≥10 g/dL, Neutrophils (ANC )≥1.5x109/L, platelet count ≥100x 109/L, TBIL<1.5 x ULN, ALT and AST ≤ 2.5 x ULN, creatinine≤1.5 x ULN
Exclusion Criteria:
Cervical esophageal cancer (The upper end of the lesion is in the esophagus of the cervical segment).
Patients with biopsy (by endoscopic ultrasound, laparoscopy, or laparotomy) proven metastatic supraclavicular or celiac nodes are ineligible.
Invasion of the tracheobronchial tree or aorta
Tracheoesophageal fistula
Concurrent pregnancy or lactation
Severe diabetes mellitus with poor blood glucose control
History of a second malignancy
Patients being unable to undergo esophageal reconstruction with gastric tube, due to prior surgery.
Patients undergoing esophageal reconstruction with jejunum.
Patients have allergy reaction or contraindications to taxanes.
Sites / Locations
- Zhejiang Cancer Hospital
- Zhejiang Cancer HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Higher dose (50.4Gy/28F) of neoadjuvant chemoradiation
Lower dose (41.4Gy/23F) of neoadjuvant chemoradiation
Neoadjuvant chemoradiation: RT: 50.4Gy/28F/5.6W; CT: paclitaxel 50mg/m2 d1, qw + CBP AUC2 d1, qw, weekly for 6 wks; Surgery: 4-6 weeks after nCRT
Neoadjuvant chemoradiation: RT: 41.4Gy/23F/4.6W; CT: paclitaxel 50mg/m2 d1, qw + CBP AUC2 d1, qw, weekly for 5 wks; Surgery: 4-6 weeks after nCRT