Efficacy of tDCS on Pain in Multiple Sclerosis
Multiple Sclerosis
About this trial
This is an interventional treatment trial for Multiple Sclerosis focused on measuring Multiple Sclerosis, Pain, Transcranial Direct Current Stimulation, tDCS
Eligibility Criteria
Inclusion Criteria:
- chronic pain defined as a constant or intermittent sensory symptom with unpleasant feelings or pain, lasting more than 3 months with a minimum score of 3 points on the Numeric Rating Scale (NRS) for pain perception;
- lack of MS worsening in the three months just before the intervention period;
- cognitive functioning to give informed consent identified by a Mini-Mental Status Examination (MMSE) score ≥ 24/30.
Exclusion Criteria:
- worsening of MS-related conditions or changes in drug therapy or any other confounding factor during the study;
- rehabilitation treatments or Botulinum toxin injections during the three months preceding the start of the study;
- intracranial metal implants that can be stimulated, incorrectly positioned, or overheated by the electric current;
- severe cardiopulmonary, renal, and hepatic diseases;
- pregnancy.
Sites / Locations
- Ferrara University HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Real-tDCS + rehabilitation programme
Sham-tDCS + rehabilitation programme
The real transcranial Direct Current Stimulation group will consist of anodal transcranial direct current stimulation applied for a total duration of 30 minutes over the the left dorsolateral prefrontal cortex and rehabilitation programme for prevention and management of pain.
The sham transcranial Direct Current Stimulation group will consist of anodal transcranial direct current stimulation applied for a total duration of 30 s over left dorsolateral prefrontal cortex and rehabilitation programme for prevention and management of pain.