Can PRP Reduce Pro-Inflammatory Biomarkers Following ACL Injury

Can Platelet Rich Plasma Reduce the Level of Pro-Inflammatory Synovial Fluid Biomarkers Following an Anterior Cruciate Ligament Tear

The purpose of this single-center, double-blinded randomized control trial with prospective data collection is to assess the ability of platelet rich plasma (PRP) treatment to reduce the level of pro-inflammatory synovial fluid biomarkers following an acute anterior cruciate ligament (ACL) tear. The study will collect and analyze synovial fluid of patients presenting with an acute anterior cruciate ligament (ACL) tear with a second synovial fluid sampling at the time of surgery. It will compare synovial fluid biomarker levels between those receiving an intra-articular Platelet Rich Plasma (PRP) injection versus an intra-articular saline injection serving as a control. Post-operative clinical outcomes will also be assessed, including post-operative pain levels, incidence of post-operative knee stiffness and patient reported outcome scores.

The synovial fluid samples obtained at the two time points will be analyzed for the presence of 20 biomarkers using a multiplex bead assay (Milliplex®, Millipore, Billerica MA)

Inclusion Criteria: Patients have suffered an acute ACL tear (initial presentation within 7 days of injury) with or without an associated meniscus injury Patient must undergo ACL reconstruction surgery Exclusion Criteria: Mentally impaired (e.g, Alzheimer's subjects, dementia, etc.) Younger than 18 years of age Patients who have a multiligamentous injury Patients with underlying inflammatory arthropathies Previous ACL injury and/or reconstruction