Noninvasive Dual-mode Stimulation Therapy for Neurorehabilitation in Stroke
Stroke
About this trial
This is an interventional treatment trial for Stroke focused on measuring Noninvasive brain stimulation, Repetitive Transcranial Magnetic Stimulation, Transcranial Direct Current Stimulation
Eligibility Criteria
Inclusion Criteria:
- First-ever stroke patients
- Subacute stage (less than 4 weeks)
- Total Fugl-Meyer Assessment (FMA) score under 84
Exclusion Criteria:
- Major active neurological disease or psychiatric disease
- A history of seizure
- Metallic implants in their brain
Sites / Locations
- Samsung Medical Center
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Dual-mode stimulation
Single sham stimulation
Dual-mode stimulation is applied over the bilateral primary motor cortex (M1) using active rTMS and active tDCS. 1 Hz of rTMS is applied over the contralesional M1 for 20 minutes with simultaneous application of anodal tDCS on the ipsilesional M1. Each participant's total FMA score is assessed and their resting-state fMRI data at two times: prior to stimulation (pre-stimulation) and 2 months after stimulation (post-stimulation) are acquired.
Single sham stimulation is applied over the bilateral primary motor cortex (M1) using active rTMS and sham tDCS. 1 Hz of rTMS over the contralesional M1 was applied for 20 minutes with simultaneous application of tDCS with sham mode (no stimulation) on the ipsilesional M1. Each participant's total FMA score is assessed and their resting-state fMRI data at two times: prior to stimulation (pre-stimulation) and 2 months after stimulation (post-stimulation) are acquired.