Second and Third Look Laparoscopy in pT4 Colon Cancer Patients for Early Detection of Peritoneal Metastases (COLOPEC-II)
Colorectal Cancer, Peritoneal Metastases
About this trial
This is an interventional diagnostic trial for Colorectal Cancer focused on measuring pT4 colon cancer, Peritoneal metastases, Early detection, Diagnostic laparoscopy, Second look surgery, Third look surgery
Eligibility Criteria
Inclusion Criteria:
- Curative intent resection of pT4a,bN0-2M0 colon cancer or rectosigmoid cancer above the peritoneal reflection, with or without adjuvant systemic therapy;
- Age between 18 and 80 years;
- Written informed consent.
Exclusion Criteria:
- Histological subtype other than (mucinous) adenocarcinoma or signet-ring cell carcinoma;
- Clinical condition that does not allow for second look surgery or subsequent treatment of PM if detected;
- Second look surgery thought not to be technically possible (i.e. because of extensive abdominal surgery / re-interventions).
Sites / Locations
- FlevoziekenhuisRecruiting
- Amsterdam UMC, location AMCRecruiting
- Amsterdam UMC, location VUmcRecruiting
- Antoni van LeeuwenhoekRecruiting
- OLVGRecruiting
- Catharina hospitalRecruiting
- University Medical Center GroningenRecruiting
- St. Antonius hospitalRecruiting
- RadboudumcRecruiting
- University Medical Center UtrechtRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
2nd look DLS + routine FU
2nd and 3rd DLS + routine FU
Follow-up after curatively resected pT4 colon cancer, consisting of second look DLS after negative CT abdomen at 6-9 months and normal CEA, with subsequent routine follow-up according to the Dutch colorectal cancer guideline until 5 years.
Follow-up after curatively resected pT4 colon cancer, consisting of second look DLS after negative CT abdomen at 6-9 months and normal CEA, with subsequent routine follow-up and third look DLS after negative CT abdomen at 18 months and normal CEA. Third look DLS is not performed in patients with evidence of disease that is not curable, or in those already diagnosed with PM in the preceding period.