Opioid Free Anesthesia and Major Spine Surgery
Opioid Use, Postoperative Pain, Spine Disease
About this trial
This is an interventional treatment trial for Opioid Use focused on measuring Lidocaine, Dexmedetomidine, Opioid-free
Eligibility Criteria
Inclusion Criteria:
- Age group: 18-80 years old
- American Society of Anesthesiologists (ASA )class I, II and III
- Elective spine posterior instrumentation surgery of at least two levels.
Exclusion Criteria:
- Renal, hepatic or cardiac insufficiency.
- Alcohol or drug abuse.
- Psychiatric disease.
- Allergy or contraindication to any of the study drugs.
- Inability to comprehend pain assessment or inability to use a Patient Controlled Analgesia (PCA) device.
Sites / Locations
- LAU Medical Center
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Opioid based Anesthesia
Opioid Free Anesthesia
General anesthesia will be induced using Propofol , fentanyl , and Rocuronium . Ketamine will be administered on induction of anesthesia with the same dose to be repeated every hour. Anesthesia will be maintained with Remi-fentanyl , sevoflurane and nitrous oxide.
-General anesthesia will be induced using dexmedetomidine and lidocaine started 10 minutes before induction, Propofol and Rocuronium . Ketamine will be administered on induction of anesthesia with the same dose to be repeated every hour. Anesthesia will be maintained with IV infusion of dexmedetomidine , lidocaine , sevoflurane and nitrous oxide.