Study to Evaluate Efficacy and Safety of PF-04965842 With or Without Topical Medications in Subjects Aged 12 Years and Older With Moderate to Severe Atopic Dermatitis (JADE EXTEND)
Dermatitis, Atopic
About this trial
This is an interventional treatment trial for Dermatitis, Atopic focused on measuring atopic dermatitis, atopic eczema, eczema, JAK, janus kinase, Magnetic Resonance Imaging, MRI
Eligibility Criteria
Inclusion Criteria:
- Evidence of a personally signed and dated informed consent document indicating that the subject or their parent(s)/legal guardian, if applicable, have been informed of all pertinent aspects of the study.
- Male or female subjects of 12 years of age or older, at the time of informed consent and meets inclusion criterion for minimum body weight (if applicable) from qualifying Parent study. Adolescent subjects below the age of 18 years old (or country-specific age of majority) will only be enrolled in this study if instructed by the sponsor and approved by the country or regulatory/health authority. If these approvals have not been granted, only subjects aged 18 years (or country-specific age of majority) and older will be enrolled.
- Willing and able to comply with scheduled visits, treatment plan, laboratory tests and other study procedures.
- Must have completed the full treatment period of a qualifying Parent study OR must have completed the full rescue treatment period of a qualifying Parent study (if applicable) OR must have completed the full open-label run-in period in B7451014 and did not meet the protocol-specified response criteria at Week 12.
Female subjects who are of childbearing potential (which includes all female subjects aged 12 years and older, regardless of whether they have experienced menarche) must ot be intending to become pregnant, currently pregnant, or lactating. The following onditions apply:
- Female subjects of childbearing potential must have a confirmed negative pregnancy test prior to allocation to treatment.
- Female subjects of childbearing potential must agree to use a highly effective method of contraception (as per Section 4.4.1) for the duration of the active treatment period and for at least 28 days after the last dose of investigational product.
For Czech Republic only, 5 b. is revised and 5 c. is added to require:
Female subjects of childbearing potential 15 years of age who are at risk of pregnancy must agree to use a highly effective method of contraception for the duration of the active treatment period and for at least 28 days after the last dose of investigational product.
c. Female subjects less than 15 years of age must not be sexually active, and abstinence per the below definition should be confirmed prior to enrollment. NOTE: Sexual abstinence, defined as completely and persistently refraining from all heterosexual intercourse (including during the entire period of risk associated with the study treatments) may obviate the need for contraception ONLY if this is the preferred and usual lifestyle of the subject.
6. Female subjects of non-childbearing potential must meet at least 1 of the following criteria:
- Have undergone a documented hysterectomy and/or bilateral oophorectomy;
- Have medically confirmed ovarian failure; or
Achieved postmenopausal status, defined as follows: cessation of regular menses for at least 12 consecutive months with no alternative pathological or physiological cause and have a serum follicle-stimulating hormone (FSH) level confirming the postmenopausal state. All other female subjects (including female subjects with tubal ligations) are considered to be of childbearing potential. 7. Must agree to avoid prolonged exposure to the sun and not to use tanning booths, sun lamps or other ultraviolet light sources during the study.
8. Must agree to avoid use of prohibited medications throughout the duration of the study. Exclusion Criteria
- Other acute or chronic medical or psychiatric condition including recent (within the past year) or active suicidal ideation or behavior or laboratory abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the subject inappropriate for entry into this study.
- Currently have active forms of other inflammatory skin diseases, ie, not AD or have evidence of skin conditions (eg, psoriasis, seborrheic dermatitis, Lupus) at the time of Day -1 that would interfere with evaluation of atopic dermatitis or response to treatment.
- Discontinued from treatment (or rescue treatment period/open-label run-in period, if applicable) early in a qualifying Parent study OR triggered a discontinuation criterion at any point during the qualifying Parent study which in the opinion of the investigator, or sponsor, is an ongoing safety concern.
- Ongoing adverse event in the qualifying Parent study which in the opinion of the investigator, or sponsor, is an ongoing safety concern.
- Investigator site staff members directly involved in the conduct of the study and their family members, site staff members otherwise supervised by the investigator, or subjects who are Pfizer employees, including their family members, directly involved in the conduct of the study.
There are also additional separate inclusion and exclusion criteria to assess eligibility specifically for the B7451015 MRI sub-study.
Sites / Locations
- Total Skin and Beauty Dermatology Center, PC
- Clinical Research Center of Alabama, LLC
- University of Alabama at Birmingham - Dermatology Research Clinic
- University of Alabama at Birmingham Hospital Outreach Lab
- Clinical Research Center of Alabama, LLC
- The University of Alabama at Birmingham, Department of Dermatology
- Emmaus Research Center, Inc.
- California Dermatology & Clinical Research Institute
- First OC Dermatology Research Inc
- First OC Dermatology
- Marvel Research, LLC
- Tilda Research Inc.
- Beach Allergy and Asthma Specialty Group, A Medical Corporation
- Keck School of Medicine of University of Southern California
- University of Southern California
- Wallace Medical Group, Inc
- Allergy & Asthma Associates of Southern California dba Southern California Research
- Dermatology Specialists, Inc.
- Peninsula Headlands LLC
- UC Davis Health
- MedDerm Associates
- University of California San Diego Dermatology
- Synergy Dermatology
- San Luis Dermatology and Laser Clinic
- Southern California Dermatology, Inc.
- Wolverine Clinical Trials, Llc
- Mosaic Dermatology
- Clinical Science Institute
- Asthma and Allergy Associates, PC
- Colorado Springs Dermatology Clinic, PC
- Skin Care Research
- Renaissance Research and Medical Group, Inc
- Florida Academic Centers Research and Education, LLC
- Skin Research Institute
- Moonshine Research Center, Inc.
- Homestead Research Institute
- Clinical Neuroscience Solutions, Inc.
- Solutions Through Advanced Research, Inc.
- C & R Research Services USA, Inc
- Savin Medical Group LLC
- Wellness Clinical Research, LLC
- Clinical Trials Solutions
- Global Health Clinical Trials Corp
- Baumann Cosmetic and Research Institute
- Suncoast Research Associates
- La Salud Research Clinic, Inc.
- Nicklaus Children's Hospital
- South Miami Medical & Research Group, Inc.
- Ciocca Dermatology, PA
- Miami Dermatology & Laser Research, LLC
- INTERMED Medical Research Center, Inc
- Suncoast Research Associates
- Park Avenue Dermatology
- Clinical Neuroscience Solutions, Inc.
- AdventHealth Orlando
- AdventHealth Pediatric Dermatology Orlando
- Advent Health Orlando - Investigational Drug Services
- Outpatient Services Center - AdventHealth Orlando
- Pediatric Outpatient Procedures and Sedation
- Accel Research Sites - Nona Pediatric Center
- Olympian Clinical Research
- Clinical Research Trials of Florida, Inc.
- Clinical Research Trials of Florida
- Center for Clinical Studies
- University of South Florida; Asthma, Allergy and Immunology Clinical Research Unit
- Olympian Clinical Research
- Olympian Clinical Research
- Integrated Clinical Research
- Columbus Regional Research Institute
- IACT Health
- Dermatologic Surgery Specialists, PC
- One Health Research Clinic
- Meridian Clinical Research
- ASR, LLC
- Midwest Allergy Sinus Asthma, SC
- NorthShore University HealthSystem - Dermatology
- NorthShore University HealthSystem Dermatology Clinical Trials Unit
- Dundee Dermatology
- Ds Research
- Dawes Fretzin Clinical Research Group, LLC
- Dawes Fretzin Dermatology Group, LLC
- The Indiana Clinical Trials Center
- The South Bend Clinic Center for Research
- Kansas City Dermatology, PA
- Skin Sciences, PLLC
- Qualmedica Research, LLC.
- Owensboro Dermatology Associates
- Meridian Clinical Research, LLC
- Avant Research Associates LLC
- Tulane University Health Sciences Center
- Institute for Asthma and Allergy
- DermAssociates, LLC
- Chesapeake Clinical Research, Inc.
- Tufts Medical Center
- Massachusetts General Hospital - Clinical Unit for Research Trials in Skin (CURTIS)
- MetroBoston Clinical Partners, LLC
- Clarkston Skin Research
- Henry Ford Medical Center, New Center One
- Onyx Clinical Research
- Hamzavi Dermatology
- Revival Research Institute, LLC
- Somerset Skin Centre
- Henry Ford Medical Center - Farmington Road
- Clinical Research Institute, Inc.
- Mayo Clinic
- MediSearch Clinical Trials
- Saint Louis University Dermatology
- Skin Specialists PC
- Forest Hills Dermatology Group
- Forest Hills Dermatology Group
- Icahn School of Medicine at Mount Sinai
- Forest Hills Dermatology Group
- UR Dermatology at College Town
- Investigational Drug Service
- Cary Dermatology Center, PA
- PMG Research of Raleigh, LLC d/b/a PMG Research of Cary
- Medication Management, LLC
- M3-Wake Research, Inc.
- Carolina Research Center, Inc.
- Accellacare - Wilmington
- PMG Research of Wilmington, LLC
- PMG Research of Winston-Salem, LLC
- Winston-Salem Dermatology and Surgery Center, PLLC
- Dermatologists of Greater Columbus
- The Ohio State University Wexner Medical Center
- The Ohio State University Dermatology East
- Lynn Health Science Institute
- Newton Clinical Research
- Vital Prospects Clinical Research Institute, P.C.
- Portland Clinical Research dba Columbia Asthma & Allergy Clinic
- Velocity Clinical Research, Medford
- Oregon Medical Research Center
- Oregon Health & Science University
- Paddington Testing Co, Inc.
- Synexus Clinical Research US, Inc.
- MUSC SCTR Research Nexus Clinic and Laboratory
- Health Concepts
- Tanenbaum Dermatology Center
- Clinical Neuroscience Solutions, Inc.
- International Clinical Research - Tennessee LLC
- Arlington Research Center, Inc.
- The University of Texas Health Science Center Houston
- Menter Dermatology Research Institute
- Center for Clinical Studies, LTD. LLP
- Ventavia Research Group
- Austin Institute for Clinical Research, Inc.
- Texas Dermatology and Laser Specialists
- Dermatology Clinical Research Center of San Antonio
- Center for Clinical Studies, LTD.LLP
- Summit Clinical Research, LLC
- Virginia Clinical Research, Inc
- Virginia Dermatology and Skin Cancer Center
- Fort Norfolk Diagnostic Center
- Pace Dermatology Associates
- Dermatology Associates of Seattle
- Dermatology Specialists of Spokane
- Principle Research Solutions
- MultiCare Allenmore Hospital
- Multicare Institute for Research and Innovation
- Pace Dermatology Associates
- Children's Hospital of Wisconsin Investigational Drug Service
- Children's Hospital of Wisconsin Translational Research Unit
- CONEXA Investigación Clínica S.A.
- CONEXA Investigación Clínica S.A.
- Framingham Centro Medico
- Hospital Universitario Austral
- Servicio de Investigacion de Patolog-ias Alergicas del Instituto ABC - Rosario
- Psoriahue Medicina Interdisciplinaria
- CINME Centro de Investigaciones Metabolicas
- Woden Dermatology
- St George Dermatology & Skin Cancer Centre
- Australian Clinical Research Network
- Royal North Shore Hospital
- The Skin Hospital
- The Skin Centre
- Veracity Clinical Research Pty Ltd
- North Eastern Health Specialists
- Eastern Health - Box Hill Hospital
- Skin Health Institute Inc.
- Sinclair Dermatology
- Royal Melbourne Hospital
- The Royal Children's Hospital
- Emeritus Research
- Royal Melbourne Hospital
- Royal North Shore Hospital
- University Hospital Brussels
- Cliniques Universitaires Saint-Luc
- University Hospital Antwerp
- Instituto de Dermatologia e Estética do Brasil LTDA
- Hospital de Clinicas de Porto Alegre (HCPA)
- Associacao dos Funcionarios Públicos do Estado do Rio Grande do Sul - Hospital Ernesto Dornelles
- Fundacao do ABC - Faculdade de Medicina do ABC
- Tecnolab Medicina Diagnostica
- Pesquisare Saude S/S Ltda
- Tecnolab - Unidade Matriz
- IBPClin Pesquisa Clinica
- MHAT Dobrich AD
- MC Asklepii" OOD
- MHAT ''Dr. Tota Venkova'' AD
- "Acibadem City Clinic MHAT Tokuda" EAD
- "DCC Aleksandrovska" EOOD
- "DCC Fokus-5-Medical Establishment for OutpatientCare"EOOD
- Military Medical Academy MHAT Sofia
- Dermatology Clinic "Sofia" - group practice for specialized outpatient medical care
- "Mc Synexus Sofia" Eood
- ACIBADEM City Clinic Diagnostic-Consultative Center EOOD
- Medical Center Synexus Sofia EOOD-branch Stara Zagora
- "ACIBADEM City Clinic Medical Center Varna" EOOD
- "DCC Mladost-M Varna" OOD
- Dermatology Research Institute
- Dermatology Research Institute
- Beacon Dermatology
- Stratica Medical
- Alberta Dermasurgery Centre
- CARE Clinic Ltd
- Dr. Chih-ho Hong Medical Inc
- University of British Columbia Department of Dermatology and Skin Science
- Pacific Dermaesthetics Inc.
- Winnipeg Clinic
- Wiseman Dermatology Research Inc.
- Karma Clinical Trials, Inc.
- CCA Medical Research
- SimcoDerm Medical and Surgical Dermatology Center
- Kingsway Clinical Research
- Derm Effects
- Lynderm Research Inc.
- DermEdge Research
- North Bay Dermatology Centre
- The Centre for Clinical Trials
- Oshawa Clinic Dermatology Trials
- Dermatology Ottawa Research Centre
- SKiN Centre for Dermatology
- The Centre for Dermatology
- York Dermatology Clinic and Research Centre
- Medicor Research Inc
- Sudbury Skin Clinique
- North York Research Inc.
- Toronto Research Centre
- Research Toronto
- AvantDerm
- Manna Research Inc.(Toronto)
- K.Papp Clinical Research Inc.
- XLR8 Medical Research Inc.
- XLR8 Medical Research Inc.
- Clinique de Radiologie du Saguenay Enr.
- Intermed groupe santé
- Innovaderm Research Inc.
- Diex Research Sherbrooke Inc.
- Dr. Rachel Asiniwasis, Medical Professional Corp.
- Centre de Recherche Dermatologique du Quebec metropolitain (CRDQ)
- Centre de Recherche Saint-Louis
- Centro Medico SkinMed Limitada
- Clinica Dermacross S.A.
- Centro Internacional de Estudios Clinicos - CIEC
- CEC Spa
- MIRES (M Y F Estudios Clínicos Limitada)
- Hospital Clinico Universidad de Chile
- Peking University First Hospital
- Beijing Friendship Hospital, Capital Medical University
- The First Affiliated Hospital Of Fujian Medical University
- The First Affiliated Hospital, Sun Yat-sen University
- The Third Affiliated Hospital, Sun Yat-sen University
- The University of Hong Kong - Shenzhen Hospital
- Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
- The second Xiangya Hospital,Central South University
- The Third Xiangya Hospital of Central South University, Dermatological department
- The First Affiliated Hospital With Nanjing University
- Dermatology Hospital of Jiangxi Province
- Jinan Central Hospital
- Shandong Provincial Institute of Dermatology and Venereology & Shandong Provincial Hospital for Skin
- Huashan Hospital Fudan University
- Tianjin Medical University General Hospital, Dermatological Department
- First Affiliated Hospital of Kunming Medical University
- The First Affiliated Hospital of Zhejiang University School of Medicine/Dermatology and STD Dept
- Hangzhou Third Hospital
- The Second Affiliated Hospital of Zhejiang University School of Medicine/Dermatology Dept
- Zhejiang Provincial People's Hospital/Dermatology Department
- Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
- The Second Affiliated Hospital of Army Medical University,PLA
- Dermatology Department, Shanghai Changzheng Hospital
- Xin Hua Hospital Affiliated to Shanghai Jiaotong University School of Medicine/Dermatology
- Shanghai Dermatology Hospital
- Lekarna Pod Kankem
- Kozni ambulance Kutna Hora, s.r.o
- Dermamedica S.R.O.
- Lekarna U Stribrneho orla (Pharmacy)
- Lekarna Fakultni Nemocnice Ostrava
- Fakultni Nemocnice Ostrava, Kozni oddeleni
- CCR Ostrava, s.r.o.
- Lekarna Rezidence Nova Karolina
- Apavar Lekarna
- BENU Lekarna
- CCR Czech a.s.
- Lekarna, Nemocnice Pardubickeho kraje, a.s. , Pardubicka nemocnice
- Nemocnice Pardubickeho kraje, a.s., Pardubicka nemocnice
- Lekarna Pod Platany (Pharmacy)
- Lekarna Pod Platany
- Prof. MUDr.Petr Arenberger, DrSc. MBA
- CCR Prague, s.r.o.
- Lekarna U Spasitele
- Dermatovenerologicka ambulance
- Lekarna na Hranicni (Pharmacy)
- Krajska zdravotni a.s., Masarykova nemocnice o.z.
- Lekarna Masarykovy nemocnice v Usti nad Labem, o.z.
- Terveystalo Tampere
- Mehiläinen Neo
- Turun yliopistollinen keskussairaala
- Velocity Clinical Research, Leipzig
- Dermazentrum Augsburg
- Licca Clinical Research Institute
- Fachklinik Bad Bentheim
- Charite-Universitaetsmedizin Berlin
- Hautzentrum Friedrichshain Studien
- Rothhaar Studien GmbH
- ISA GmbH
- Klinikum Bielefeld Rosenhoehe
- Universitaetsklinikum Bonn
- Klinische Forschung Dresden GmbH
- Universitaetsklinikum Carl Gustav Carus der Technischen Universitaet Dresden
- Universitätsklinikum Erlangen
- IKF Pneumologie GmbH & Co KG; Institut für klinische Forschung
- SRH Wald-Klinikum Gera GmbH
- Klinische Forschung Hamburg GmbH
- MENSINGDERMA research GmbH
- Medizinische Hochschule Hannover
- Universitaetsklinikum Schleswig-Holstein, Campus Kiel
- Praxis Dr. med. Beate Schwarz
- SIBAmed Studienzentrum GmbH
- Universitaetsklinikum Schleswig-Holstein, Campus Luebeck
- Dermatologische Gemeinschaftspraxis
- Dermatologische Gemeinschaftspraxis Dres. Quist
- Universitätsklinikum Marburg
- University of Muenster
- Ludwig-Maximilians-University Munich
- Klinische Forschung Schwerin GmbH
- Hautaerztliche Gemeinschaftspraxis Dres. Leitz und Kollegen
- Clinexpert Kft.
- SE AOK Bor, Nemikortani es Boronkologiai Klinika
- Bp. Főváros XIX. Kerület Önkormányzat Kispesti Eü. Intézete
- Debreceni Egyetem Klinikai Kozpont
- CRU Hungary Kft.
- Synexus Magyarország Egészségügyi Szolgáltató Kft. Synexus Gyula DRS
- Bugát Pál Kórház, Bőrgyógyászati Szakrendelés
- Trial Pharma Kft.
- Trial Pharma Kft.
- Borsod-Abaúj-Zemplén Megyei Központi Kórház és Gyermek Gasztroenterológia II. emelet
- Pecsi Tudomanyegyetem Klinikai Kozpont, Bor-,Nemikortani es Onkodermatologiai Klinika
- Trial Pharma Kft.
- Szegedi Tudomanyegyetem Szent-Györgyi Albert
- ALLERGO-DERM BAKOS Kft.
- Medmare Bt
- Soroka University Medical Center
- Rabin Medical Center
- The Chaim Sheba Medical Center
- Tel-Aviv Sourasky Medical Center
- AOU Policlinico Sant'Orsola Malpighi
- Universita degli Studi G. D'Annunzio -CeSi-MeT
- Ospedale Policlinico San Martino
- AOU Policlinico di Modena Struttura complessa di Dermatologia
- ASST Fatebenefratelli Sacco
- Istituto Clinico Humanitas IRCSS - UOC di Dermatologia
- IFO lstituto Dermatologico San Gallicano IRCCS
- Universita del Sacro Cuore, Policlinico Agostino Gemelli, Istituto Di Dermatologia
- Kawashima Dermatology Clinic
- Takagi Dermatological Clinic Branch
- Takagi Dermatological Clinic
- Dermatology Shimizu Clinic
- Queen's square Medical Facilities Queen's square Dermatology and Allergology
- Noguchi Dermatology Clinic
- Osaka Habikino Medical Center
- Yoshioka Dermatology Clinic
- Dermatology and Ophthalmology Kume Clinic
- Iidabashi Skin Clinic
- Fukuwa Clinic
- Sumire Dermatology Clinic
- Sumire Dermatology Clinic
- Matsuyama Dermatology Clinic
- Tokyo Medical University Hospital
- Hoshikuma Dermatology・Allergy Clinic
- Matsuda Tomoko Dermatological Clinic
- Sanrui Hifuka
- Korea University Ansan Hospital
- Soon Chun Hyang University Bucheon Hospital
- Kyungpook National University Hospital
- Chungnam National University Hospital CNUH
- Chonnam National University Hospital
- The Catholic University of Korea, Incheon St. Mary's Hospital
- Inha University Hospital
- Korea University Anam Hospital
- Severance Hospital, Yonsei Univ. Health System
- The Catholic University of Korea, Seoul St. Mary's Hospital
- Chung-Ang University Hospital
- Hallym University Kangnam Sacred Heart Hospital
- Riga 1st Hospital, Clinic of Dermatology and STD
- Aesthetic dermatology clinic of Prof. J. Kisis
- Health Centre 4 Ltd. Diagnostics Centre
- Childrens Clinical University Hospital State SLLC
- Health and Aesthetics Ltd
- Health Centre 4 Ltd, Dermatology Clinics
- Outpatient Clinic Of Ventspils
- Hospital Infantil de Mexico Federico Gomez
- Clinical Research Institute S.C.
- JM Research SC
- Centro de Dermatologia de Monterrey
- Centro Multidisciplinario para el Desarrollo Especializado de la Investigacion Clinica en Yucatan
- Unidad de Atención Médica e Investigación en Salud
- Derma Norte del Bajio S.C.
- Servicios Hospitalarios de Mexico S.A. de C.V. (Hospital Ángeles Chihuahua)
- Centro de Investigacion Integral MEDIVEST, S.C.
- Phylasis Clinicas Research S. de R.L. de C.V.
- Hospital de Jesus, I.A.P.
- Cryptex Investigación Clínica, S.A. de C.V.
- Arke Estudios Clinicos Sa De Cv
- Trials in Medicine S.C.
- Eukarya Pharmasite S.C.
- SMIQ, S. de R. L. de C.V.
- Sociedad de Metabolismo y Corazon S.C.
- Universitair Medisch Centrum (UMC) Utrecht
- NZOZ Specjalistyczny Osrodek Dermatologiczny DERMAL s.c.
- KLIMED Marek Klimkiewicz
- Clinica Dermatoestetica Prywatny Gabinet Dermatologiczny i Alergologiczny
- DERMAPOLIS Medical Dermatology Center dr n. med. Edyta Gębska
- Synexus Polska Sp. z o.o. Oddzial w Czestochowie
- Uniwersyteckie Centrum Kliniczne Klinika Dermatologii, Wenerologii i Alergologii
- Neutrum Lekarze M. Hlebowicz i Partnerzy Spolka Partnerska
- Szpital Sw. Wojciecha
- Synexus Polska Sp. z o.o. Oddzial w Gdyni
- MCBK
- Synexus Polska Sp. z o.o. Oddzial w Katowicach
- MULTIKLINIKA Salute Sp. z o.o.
- Silmedic Sp. z o.o., Oddzial w Katowicach
- Care Clinic Centrum Medyczne
- Centrum Medyczne Angelius Provita
- Pro Familia Altera Sp. z o.o.
- Gabinet Dermatologiczny Beata Krecisz
- Gabinet Dermatologiczny Beata Krecisz
- Malopolskie Centrum Kliniczne
- Centrum Badan Klinicznych JCI
- Centrum Medyczne Plejady
- Centrum Nowoczesnych Terapii "DOBRY LEKARZ" sp. z o.o.
- AWP Klinika Dermatologii Pod Fortem Anna Wojas-Pelc
- Centrum Medyczne Promed
- Krakowskie Centrum Medyczne Sp. z o.o.
- Prywatna Praktyka Lekarska - Adam Smialowski INTERMED KSAWEROW
- Centrum Terapii Wspolczesnej J.M. Jasnorzewska Spolka Komandytowo-Akcyjna
- NZOZ "DERMED" Centrum Medyczne Sp. z o.o. - Oddzial w Lodzi
- Centrum Terapii Wspolczesnej J.M. Jasnorzewska Spolka Komandytowo-Akcyjna
- Osrodek badan klinicznych AppleTree Clinics
- Dermoklinika-Centrum Medyczne s.c. M. Kierstan, J. Narbutt, A. Lesiak
- KO-MED Centra Kliniczne Lublin II
- NZOZ "Med-Laser" Borzecki Spolka Jawna
- Dermedic Jacek Zdybski
- Synexus Polska Sp. z o.o. Oddzial w Poznaniu
- Clinical Research Center Sp. z o.o. MEDIC-R Sp. k.
- Gabinety Lekarskie Rivermed
- LIFT-MED Spolka Akcyjna
- Kliniczny Szpital Wojewodzki nr 1 im. F. Chopina, Klinika Dermatologii
- EMED Centrum Uslug Medycznych Ewa Smialek
- Andrzej Krolicki, Tomasz Kochanowski "Laser Clinic" S.C.
- Twoja Przychodnia Szczecinskie Centrum Medyczne
- Alergo-Med Specjalistyczna Przychodnia Lekarska Sp. z o.o.
- MICS Centrum Medyczne Warzawa
- Synexus Polska Sp. z o.o. Oddzial w Warszawie
- Centrum Medyczne AMED
- MTZ Clinical Research Powered by Pratia
- Centralny Szpital Kliniczny Ministerstwa Spraw Wewnetrznych i Administracji w Warszawie
- RCMed Oddzial Warszawa
- Carpe Diem Centrum Medycyny Estetycznej
- REUMATIKA - "Centrum Reumatologii" NZOZ 2
- Synexus Polska Sp. z o.o. Oddzial w Warszawie
- ETG Warszawa
- Klinika Ambroziak Sp. z o.o.
- Wojskowy Instytut Medyczny, Klinika Dermatologiczna
- EMC Instytut Medyczny S.A. Przychodnia przy ul. Lowieckiej
- Synexus Polska Sp. z o.o. Oddzial we Wroclawiu
- Lukasz Matusiak "4Health"
- Centrum Medyczne Oporow
- Kliniczny Oddzial Chorob Wewnetrznych, Dermatologii i Alergologii
- SC Centrul Medical de Diagnostic si Tratament Ambulator Neomed SRL
- Cabinet Medical de Dermatovenerologie Prof. Dr. Orasan Remus Ioan
- SC Delta Health Care SRL
- SBIH "Chelyabinsk Regional Clinical Dermatovenerology dispensary"
- Limited Liability Company "Medical Center "Rheuma-Med"
- Clinic of FSBEI HE Kirov SMU MOH Russia
- FSBI "State Research Centre of Dermatovenereology and Cosmetology" MoH RF
- NRC Institute of Immunology FMBA of Russia
- SBI RR "Skin and Venereal Dispensary"
- SBI RR "Regional Clinical Skin and Veneral Dispensary"
- Limited Liability Company "Sanavita"
- LLC "Pierre Wolkenstein Clinic of Skin Diseases"
- Vitiligo center
- FSBEI HE "St. Petersburg State Pediatric Medical University" MoH RF
- "Medical Research Institute", LLC
- FSBEI HE I.P.Pavlov SPbSMU MOH Russia
- RSBIH "Smolensk Regional Clinical Hospital"
- Military Medical Academy
- Clinical Centre Nis
- General Hospital Pancevo
- Summit Clinical Research, s.r.o.
- Summit Clinical Research, s.r.o.
- SKINKLINIK s.r.o.
- SUMMIT CLINICAL RESEARCH, s.r.o., Ambulancia vnutorneho lekarstva
- Narodny ustav detskych chorob
- BeneDerma s.r.o.
- Derma therapy spol. s.r.o, Dermatovenerologicka ambulancia
- Nemocnica Kosice-Saca, a.s., 1. sukromna nemocnica, Kozna ambulancia
- Derma-beauty, s.r.o., Dermatovenerologicka ambulancia
- Fakultna nemocnica s poliklinikou Nove Zamky, Dermatovenerologicka klinika
- SANARE spol.s.r.o.
- Hospital Universitari Germans Trias i Pujol
- Hospital Sant Joan de Deu
- Hospital Universitario de Gran Canaria Dr. Negrin
- Hospital Universitario Fundacion Alcorcon
- Hospital Universitario Puerta de Hierro de Majadahonda
- Hospital General Universitario de Alicante
- Hospital Clinic de Barcelona
- Hospital de la Santa Creu i Sant Pau Servicio de Dermatologia
- Hospital Universitario Reina Sofia
- Hospital Universitario de La Princesa
- Hospital General Universitario Gregorio Maranon
- Hospital del Nino Jesus
- Hospital Universitario 12 de octubre
- Hospital Universitario La Paz
- Centro de Especialidades Mollabao (Area Sanitaria de Pontevedra e O Salnes)
- Hospital de Montecelo
- Hospital Universitario Virgen de la Macarena
- Consorcio Hospital General Universitario de Valencia
- Hospital Universitario y Politecnico La Fe
- Hospital Universitario Miguel Servet
- Taipei Veterans General Hospital
- Kaohsiung Medical University Chung-Ho Memorial Hospital
- Taipei Medical University-Shuang Ho Hospital
- Chung Shan Medical University Hospital
- Taichung Veterans General Hospital
- National Cheng-Kung University Hospital
- National Taiwan University Hospital
- Mackay Memorial Hospital
- Chang Gung Memorial Hospital Linkou Branch
- Medinova Research
- MeDiNova West London Quality Research Sites
- Plymouth Hospitals NHS Trust, Derriford Hospital
- Royal free London NHS Foundation Trust
- MeDiNova South London Quality Research Site
- Accellacare North London
- Barnsley Hospital NHS Foundation Trust
- Sheffield Children's NHS Foundation Trust
- Sheffield Teaching Hospitals NHS Foundation Trust, Northern General Hospital
- MAC Clinical Research
- University Hospital Bristol NHS Foundation Trust
- MAC Clinical Research
- Accellacare Warwickshire
- West Glasgow Ambulatory Care Hospital
- Guy's Hospital-Guy's and St Thomas NHS Foundation Trust
- MAC Clinical Research Ltd
- Accellacare South London
- Accellacare Yorkshire
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Abrocitinib 100 mg
Abrocitinib 200 mg
Abrocitinib 100 mg QD PO
Abrocitinib 200 mg QD PO