Venous Thromboembolism in Myotonic Dystrophy Type 1 (DM1-VTE)
Myotonic Dystrophy 1
About this trial
This is an interventional other trial for Myotonic Dystrophy 1 focused on measuring Myotonic dystrophy 1, Venous thromboembolism, Pulmonary embolism, Deep vein thrombosis, Hypercoagulability, Thrombophilia, RNA alternative splicing
Eligibility Criteria
Inclusion Criteria:
Population N°1
- Age over 18 years
- Patient living in France and with medical insurance
- Patient having given his informed and written consent
- DM1 groups: genetically proven DM1
- VTE groups: at least 1 history of VTE (PE and/or DVT)
- Healthy volunteers: patient without any medical history (no DM1, no VTE, no thrombophilia), and without taking any anti-thrombotic medication
Population N°2
- Liver tissue of patients with genetically proven DM1 (tissue bank)
- Liver tissue of patients without DM1 or any history of VTE (tissue bank)
Exclusion Criteria:
Patient opposed to data collection and analysis
1. Population N°1
- Genetically proven thrombophilia
- Anti-thrombotic medication
- Hemoglobin levels < 7 g/dL
Hemoglobin levels < 9 g/dL in case of cardiac of respiratory condition
2. Population N°2
- Liver tissue quality insufficient for RNA extraction and analysis
Sites / Locations
- Service de Cardiologie - Hôpital CochinRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Experimental
Active Comparator
Active Comparator
Experimental
Active Comparator
population 1-A1 : DM1 with VTE
population 1-B1 : DM1 without VTE
population 1-C1 : Healthy volunteers
population 2-A2 : DM1 liver samples
population 2-B2 : Healthy liver samples
Myotonic dystrophy type 1 patients with a history of venous thromboembolism (pulmonary embolism and/or deep vein thrombosis)
Myotonic dystrophy type 1 patients without a history of venous thromboembolism
Healthy volunteers without any medical history or treatment
Liver samples of patients with myotonic dystrophy type 1
Liver samples from patients without any medical history