Comparison of Low Versus Normal Flow Anesthesia on Cerebral Oxygenation and Bispectral Index in Morbidly Obese Patients (CerOxygen)
Morbid Obesity, Anesthesia Awareness, Anesthesia Complication
About this trial
This is an interventional screening trial for Morbid Obesity focused on measuring Bariatric surgery, Low flow anesthesia, Bispectral index, Regional cerebral oximetry
Eligibility Criteria
Inclusion Criteria:
- American Society of Anesthesiology score I-III,
- 18-65 years,
- BMI> 35
Exclusion Criteria:
- American Society of Anesthesiology IV,
- Under 18 years,
- Over 65 years,
- Obstetric patients,
- Uncontrolled diabetes mellitus, cardiovascular and pulmonary disease,
- Cerebrovascular disease,
- Patients who refused informed consent forms
Sites / Locations
- Sedat AKBAS
Arms of the Study
Arm 1
Arm 2
Active Comparator
Sham Comparator
Low flow
Normal flow
Anesthesia was maintained with desflurane inhalation with a flow of 2 L/min in 0.5 O2 oxygen-air mixture in both groups. While target minimum alveolar concentration (MAC) was 1-1.5 and the flow rate was adjusted to 0.75 L/min. Regional cerebral oxygen saturation is a useful clinical research tool for noninvasive and continuous monitoring of hemodynamic and brain oxygenation. Regional cerebral oxygen saturation (Near-infrared spectroscopy system, NIRS, Cerebral Oximeter) monitoring was performed to all patients. The most effective method for depth of anesthesia and assessment of sedation is bispectral analysis of mean frequency of electroencephalography. The values of Bispectral Index (BIS, Bispectral Index, Monitoring System) decreases with the deepening of anesthesia.
Anesthesia was maintained with desflurane inhalation with a flow of 2 L/min in 0.5 O2 oxygen-air mixture in both groups. While target minimum alveolar concentration (MAC) was 1-1.5 and the flow rate was adjusted to 1.5 L/min.Regional cerebral oxygen saturation is a useful clinical research tool for noninvasive and continuous monitoring of hemodynamic and brain oxygenation. Regional cerebral oxygen saturation (Near-infrared spectroscopy system, NIRS, Cerebral Oximeter) monitoring was performed to all patients. The most effective method for depth of anesthesia and assessment of sedation is bispectral analysis of mean frequency of electroencephalography. The values of Bispectral Index (BIS, Bispectral Index, Monitoring System) decreases with the deepening of anesthesia.