Efficacy and Safety of 0.25% Timolol Gel in Healing Surgical Open Wounds
Wound of Skin, Wound Heal, Wound Open
About this trial
This is an interventional treatment trial for Wound of Skin
Eligibility Criteria
Inclusion Criteria:
- Age greater than 18 years
- Open surgical wound ≤1.5cm
- No hypersensitivity with use of 0.25% timolol gel
Exclusion Criteria:
- Age less than 18 years of age
- Open surgical wound >1.5cm
- Pregnant women
- Use of systemic retinoids within 1 month
- Any hypersensitivity with use of 0.25% timolol gel
Sites / Locations
- Mohs and Dermatologic Surgery Center, Brigham and Women's Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
0.25% Timolol gel under the paraffin gauzes
Standard of Care dressings
Timolol 0.25% gel will be applied to wound bed immediately after surgery before dressing is applied Starting the day after surgery: each day, the patient will cleanse the surgical site, apply 0.25% topical timolol gel (1 drop = 0.1ml for each cm2 of wound area), and re-cover wound with clean dressing This daily routine continues for 12 weeks' post-surgery (even if the surgical defect has completely healed in the interim)
Vaseline will be applied to wound bed immediately after surgery before dressing is applied Starting the day after surgery: each day, the patient will cleanse the surgical site, apply Vaseline, and re-cover wound with clean dressing This daily routine continues for 12 weeks' post-surgery (even if the surgical defect has completely healed in the interim)