Comparison of HFNC With NIV in Weaning COPD
Chronic Obstructive Pulmonary Disease With (Acute) Exacerbation
About this trial
This is an interventional treatment trial for Chronic Obstructive Pulmonary Disease With (Acute) Exacerbation focused on measuring Weaning; Noninvasive ventilation; High flow nasal cannula
Eligibility Criteria
Inclusion Criteria:
- Intubated patients with Chronic obstructive pulmonary disease exacerbation
- Meeting extubation criteria (Pulmonary infection control window)
- Age > 21years and < 90 years
Exclusion Criteria:
- Tracheotomy
- Combined with severe dysfunction of other organs, including heart, brain, liver, and renal failure;
- Hemodynamic instability
- Contraindication to NIV: cannot use mask, such as facial injury, burns or deformities; cannot cooperate with NIV such as delirium; copious secretions with weak cough ability; gastric over distention, and vomiting;
- Contraindication to HFNC: rhinitis, nasal congestion, deformities or blockage.
- Weak cough ability with copious secretions
- Refuse to participate in the study
Sites / Locations
- Binzhou Medical University Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
High flow nasal cannula
Noninvasive ventilation
High flow nasal cannula (HFNC) is a type of oxygen device, which provides high concentration oxygen in a high flow, which exceeds patient's inspiratory flow demand, to improve oxygenation.
Non-invasive ventilation (NIV) refers to the provision of ventilatory support through the patient's upper airway using a mask. This technique is distinguished from those which bypass the upper airway with a tracheal tube, laryngeal mask, or tracheostomy and are therefore considered invasive.