Functional MRI Study of Cortical Modifications to Light Stimulation in Patients With Photophobia
Dry Eye Syndrome, Photophobia
About this trial
This is an interventional other trial for Dry Eye Syndrome focused on measuring functional MRI
Eligibility Criteria
Inclusion Criteria:
- Symptomatic subjects : presence of bilateral photophobia with an impact on daily activities (driving, outdoor activities, screens use, socio-professional activities…) in a context of patent dry eye syndrome
- Asymptomatic subjects : no dry eye syndrome and no photophobia
- Patients able to understand medical information and sign consent.
Exclusion Criteria:
- Ophthalmological pathologies of cornea, iris, optic nerve or retina
- MRI contraindications (metallic prosthesis, pacemaker, claustrophobia)
- Neurological pathology which may affect MRI results
- Subjects under legal protection
Sites / Locations
- University Hospital ToulouseRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Symptomatic patients with dry eye
Asymptomatic patient
8 symptomatic patients with dry eye (mild to severe) assessed using a validated questionnaire (OSDI score, Appendix 1) associated with a disabling photophobia (need to wear sunglasses permanently outside, restriction of the outputs in case of significant brightness, restriction of the use of the screens because of the visual embarrassment ...). The fMRI will be carried out following the inclusion visit after all the necessary checks
8 asymptomatic patients presenting neither photophobia (even minimal) or dry eye. The fMRI will be carried out following the inclusion visit after all the necessary checks