Lyme Disease Patients With Memory Problems

This is an interventional other trial for Lyme Disease focused on measuring Post Treatment Lyme Disease Syndrome Read More

Fifteen subjects will be selected to take part in this study. All subjects must meet the following criteria:

• Inclusion criteria:

  1. Age over 18 years, both males and females
  2. History of Lyme disease as diagnosed per CDC criteria and/or evidence of Erythema Migrans or diagnosis of Lyme disease as documented in medical record by an experienced health care practitioner.
  3. Meet defining criteria of Post Treatment Lyme Disease Syndrome (PTLDS) proposed by Infectious Diseases Society of America (IDSA)
  4. Ability to give informed consent as assessed by study physician
  5. Willing to participate in 10 tDCS sessions over two week period
  6. If on long-term antibiotics or supplements for treatment of Lyme disease must be willing to keep treatment regimen consistent during participation in the study

• Exclusion criteria:

  1. Evidence of any active Borrelia infection or co-infection such as Babesiois, Anaplasmosis, Erhlichiosis, Ricketsia as assessed by serum serology, such patient will be referred to ID
  2. Evidence of current or prior infection by B. Mioymoti or B. hemsii, such patients will be referred to ID
  3. Any of the exclusion criteria of Post Treatment Lyme Disease Syndrome (PTLDS) as proposed by Infectious Diseases Society of America (IDSA)

  4. History of other chronic inflammatory conditions such as:

     • Rheumatoid arthritis
     • Asthma
     • Autoimmune diseases
     • Chronic prostatitis
     • Glomerulonephritis
     • Celiac disease
     • Inflammatory bowel disease
     • Pelvic inflammatory disease
     • Interstitial cystitis
     • Vasculitis
  5. Existence of major neurologic or psychiatric condition such as epilepsy, severe depression or others
  6. Past history of neurosurgery
  7. History of significant alcohol or drug abuse during previous 6 months
  8. Presence of unstable medical conditions such as uncontrolled diabetes mellitus, cardiac pathology, cancer, kidney insufficiency, acute thrombosis or others
  9. Any new medication or dosage changes in the past 60 days interfering with your symptoms related to PTLDS
  10. Concurrent use of opioids or narcotics which cause CNS suppression, cognitive or motor slowing
  11. Concurrent use of muscle relaxants
  12. Concurrent use of anti-epileptics such as Carbamazepine
  13. Pregnancy as assessed by urine pregnancy test
  14. Contraindication to tDCS such as metal in the head or implanted electronic medical devices.