Back to resultsA Maintenance Study of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 2)
Primary Purpose
Ulcerative Colitis
Status
Active
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Mirikizumab SC
Mirikizumab IV
Placebo SC
Sponsored by
About this trial
This is an interventional treatment trial for Ulcerative Colitis focused on measuring Interleukin-23 (IL-23), IL-23p19, Inflammatory Bowel Disease
Eligibility Criteria
Inclusion Criteria:
- Have completed Study AMAN (NCT03518086), with at least 1 study drug administration and without early termination of study drug.
- Are willing and able to complete the scheduled study assessments, including endoscopy and daily diary entry.
- If female, must meet the contraception requirements.
Exclusion Criteria:
- Participants diagnosed with Crohn's disease or inflammatory bowel disease-unclassified (indeterminate colitis) during the induction study AMAN (NCT03518086).
- Participants with a bowel resection or other surgery for the treatment of UC during the previous induction study AMAN (NCT03518086), or are likely to require surgery for the treatment of UC during study AMBG.
- Participants with evidence of colonic dysplasia or have been diagnosed with cancer of the gastrointestinal tract during study AMAN (NCT03518086).
- Participants diagnosed with clinically important infection including, but not limited to, hepatitis B, hepatitis C, HIV/AIDS, and active tuberculosis (TB) during the induction study AMAN (NCT03518086).
- Participants who initiate a new prohibited medication during the induction study AMAN (NCT03518086).
- Participants with certain laboratory abnormalities prior to start of AMBG that would require permanent discontinuation from study drug.
Sites / Locations
- Digestive Health Specialists
- Dcr-Pi, Pc
- Maricopa Integrated Health System
- Physicians Research Group
- Valley Gastroenterology
- Care Access Research
- Om Research, LLC
- California Medical Research Associates
- Clinical Applications Laboratories, Inc.
- UCSF Medical Center at Mission Bay
- Direct Helpers Research Center
- Nature Coast Clinical Research, LLC
- SIH Research, LLC
- Wellness Clinical Research
- Columbus Clinical Services, LLC
- Research Associates of South Florida, LLC
- Center for Interventional Endoscopy
- Clintheory Healthcare
- Gastroenterology Associates of Pensacola, PA
- Florida Digestive Specialist
- Florida Medical Clinic LLC
- Digestive Healthcare of Georgia
- Grand Teton Research Group
- NorthShore University HealthSystem
- Indiana University School of Medicine
- Cotton-O'Neil Clinical Research Center, Digestive Health
- Texas Digestive Disease Consultants
- Delta Research Partners LLC
- Nola Research Works, LLC
- Clinical Research Institute of Michigan, LLC
- Henry Ford Health System
- Gastroenterology Associates of Western Michigan, P.L.C.
- Huron Gastroenterology Associates
- MNGI Digestive Health - Plymouth Endoscopy Center & Clinic
- Gen1 Research - Gastroenterology & Nutrition, PC
- Northwell Health
- Weill Cornell Medical College
- University of North Carolina Center for Inflammatory Bowel Disease
- Carolina Digestive Diseases and Endoscopy Center
- Paramount Medical Research
- Care Access - Youngstown
- Central Sooner Research
- University of Oklahoma Health Sciences Center
- Care Access Research LLC
- Digestive Disease Associates
- Midwest Medical Care
- Gastro One
- Galen Medical Group
- Digestive Health Associates of Texas
- Houston Methodist Research Ins
- Biopharma Informatic, LLC
- Gastroenterology Research of San Antonio
- Southern Star Research Institute, LLC
- Texas Digestive Disease Consultants
- Care Access Research LLC - Salt Lake City
- Emeritas Research Group
- The Gastroenterology Group, P.C.
- Carilion Clinic
- Digestive Health Specialists
- Wisconsin Center for Advanced Research
- Centro de Investigaciones Metabólicas (CINME)
- Mautalen Salud e Investigacion-Centro de Osteopatías Médicas
- CER Instituto Medico
- Fundación de Estudios Clínicos
- Centro de Investigaciones Médicas Tucuman
- C.I.C.E. 9 de Julio
- Hospital Privado Centro Medico de Cordoba SA
- Princess Alexandra Hospital
- Coastal Digestive Health
- Mater University Hospital
- Royal Adelaide Hospital
- Box Hill Hospital Outpatients
- Melbourne Gastrointestinal Investigation Unit (MGIU)
- The Alfred Hospital
- The Royal Melbourne Hospital
- Medizinische Universität Innsbruck
- Universitätsklinikum Salzburg
- Medical University of Vienna
- Universitair Ziekenhuis Gent
- Centre Hospitalier de Wallonie Picarde - Site Notre Dame
- AZ Klina
- Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg
- West Edmonton Diabetes Center
- The Gordon and Leslie Diamond Health Care Centre
- GI Research Institute
- PerCuro Clinical Research
- Victoria Hospital
- University of Western Ontario
- Centre de santé et de services sociaux Champlain-Charles-Le Moyne
- Hopital Maisonneure-Rosemount
- Inflammatory Bowel Disease Centre Montreal General Hospital - MUHC
- Anhui Provincial Hospital
- The First Affiliated Hospital of Anhui Medical University
- Beijing Friendship Hospital Affiliate of Capital University
- Xiangya Hospital Central South University
- The Affiliated 2nd Hosp. of Third Military Med. Univ. of PLA
- The First Hospital Affiliated to AMU (Southwest Hospital)
- Fujian Province Hospital
- The Sixth Affiliated Hospital, Sun Yat-Sen University
- The University of Hong Kong-Shenzhen Hospital
- Hainan General Hospital
- Union Hospital Tongji Medical College Huazhong University of Science and Technology
- Renmin Hospital of Wuhan University
- Changzhou No.2 People's Hospital
- The Affiliated Drum Tower Hospital of Nanjing University
- Jiangsu Province Hospital of Chinese Medicine
- Jiangsu Province Hospital
- Zhongda Hospital Southeast University
- Nanjing Medical University - Nanjing Jiangning Hospital
- Jiangxi Pingxiang People's Hospital
- Jilin Central General Hospital
- The Second Hospital of Dalian Medical University
- Shengjing Hospital of China Medical University
- Qilu Hospital of Shandong University
- Liaocheng People's Hospital
- The Affiliated Hospital of Medical College Qingdao Univ
- Taian City Central Hospital
- Shanghai Jiaotong University School of Medicine Ruijin Hospital
- Renji Hospital Affliated to Shanghai Jiaotong University
- West China Hospital of Sichuan University
- No.1 Hospital Affiliated to Xinjiang Medical University
- Kunming Medical College Affiliated First Hospital
- The First People's Hospital of Yunnan Province
- The Second Affiliated Hospital of Zhejiang University School of Med
- First Affiliated Hosp of College of Med, Zhejiang University
- Sir Run Run Shaw Hospital
- The Second Affiliated Hospital YuYing Childens Hospital of Wenzhou Medical university
- Tongji Hospital of Tongji University
- Vojenská Nemocnice Brno
- Fakultni nemocnice Kralovske Vinohrady
- Hepato-Gastroenterologie HK
- MUDr. Gregar, s.r.o.
- A-Shine
- MEDIENDO
- Fakultni Nemocnice u sv. Anny v Brne
- PreventaMed, s.r.o.
- ISCARE Clinical Centre
- Herlev and Gentofte Hospital
- Zealand University Hospital Køge
- Hopital de Hautepierre - Service d'Hépatogastroentérolgie
- Hopital Saint-Louis
- CHU Lille - Hôpital Claude Huriez
- Hôpital Beaujon
- Centre Hospitalier de Pau
- Hospices Civils de Lyon - Centre Hospitalier Lyon Sud -
- CHU Amiens Picardie-Site Sud - RDC Service Hépato gastro
- CHU Tours - Hôpital Trousseau
- Assistance Publique Hôpitaux de Marseille - Hôpital Nord
- CHRU de Montpellier-Hopital St Eloi
- Hopital L'Archet 2
- CHU Bordeaux - Hôpital Haut-Lévêque
- Robert Debre Hospital
- CHU de Saint Etienne Hopital Nord
- CHRU Nancy Brabois - Hôpital d'Enfants
- Medizinische Hochschule Hanover
- Gemeinschaftspraxis Dr. Peter Uebel
- Studiengesellschaft BSF Unternehmergesellschaft
- Universitätsklinikum Halle
- Charité Campus Virchow-Klinikum
- Krankenhaus Waldfriede
- Städtisches Klinikum Brandenburg
- HaFCED - Hamburgisches Forschungsinstitut für chronisch entzündliche Darmerkrankungen
- Internistische Praxisgemeinschaft
- DRC Gyogyszervizsgalo Kozpont Kft.
- Jávorszky Ödön Kórház
- Óbudai Egészségügyi Centrum
- Semmelweis Egyetem
- Debreceni Egyetem Klinikai Kozpont
- Endomedix Diagnosztikai Központ - Miskolc
- Karolina Korhaz-Rendelointezet
- Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont I. Belgyogyaszati Klinika
- CLINFAN Szolgáltató Kft
- Centre for Liver Research & Diagnostics, Deccan College of Medical Sciences, Owaisi Hospital & Research Centre
- Escorts Heart Institute and Research Centre Ltd
- Apollo Research and Innovations, Apollo Hospitals International Ltd
- Shree Giriraj Multispeciality Hospital
- Nirmal Hospital Pvt Ltd.
- Bangalore Medical College and Research Institute
- M S Ramaiah Medical College and Hospitals
- Midas Multispeciality Hospital Pvt.Ltd.
- Poona Medical Foundation. Ruby Hall Clinic
- Datta Meghe Institute of Medical Sciences (DU), Acharya Vinoba Bhave Rural Hospital
- Dayanand Medical College and Hospital
- SR Kalla Memorial Gastro & General Hospital
- King George Medical University
- Fortis Hospital
- Gandhi Hospital
- Beaumont Hospital, Dublin
- Shaare Zedek Medical Center
- Soroka Medical Center - Pediatric Outpatient Clinic
- Galilee Medical Center Department of Internal Medicine A
- Kaplan Medical Center
- Tel Aviv Sourasky Medical Center
- Assaf Harofeh Medical Center
- Presidio di Rho
- Istituto Clinico Humanitas
- Istituti di Ricovero e Cura a Carattere Scientifico Policlinico San Donato Gastroenterologia
- Ospedale Sandro Pertini
- Azienda Ospedaliera Universitaria Policlinico Tor Vergata
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)
- Azienda ospedaliero-universitaria Mater Domini
- Azienda Ospedaliero Universitaria San Martino
- Gastroenterology and Endoscopy Unit IRCCS Ca' Granda Ospedale Maggiore Policlinico Foundation
- Azienda Ospedaliera Universitaria Policlinico de Modena
- Azienda Ospedaliera Universitaria Pisana
- Policlinico Gemelli - Università Cattolica del Sacro Cuore
- Ospedale Mauriziano Umberto I
- Azienda Ospedaliero-Universitaria Santa Maria della Misericordia Gastroenterologia
- Aichi Medical University Hospital
- Fujita Health University Hospital
- National Hospital Organization Hirosaki General Medical Center
- Toho University Sakura Medical Center
- Kitakyushu Municipal Medical Center
- Hidaka Coloproctology Clinic
- Fukuoka University Chikushi Hospital
- Gunma University Hospital
- National Hospital Organization Takasaki General Medical Centar
- NHO Mito Medical Center
- Asahikawa City Hospital
- Tokushukai Sapporo Tokushukai Hospital
- Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital
- Sapporo Higashi Tokushukai Hospital
- Aoyama Clinic GI Endoscopy & IBD Center
- Kagawa Prefectural Central Hospital
- Sankikai Yokohama Shin midori General Hospital
- Ofuna Central Hospital
- Kawasaki Municipal Hospital
- Yokohama City University Medical Center
- Showa University Northern Yokohama Hospital
- Kumamoto University Hospital
- Mie University Hospital
- Takagi Clinic - Sendai
- Nagaoka Chuo General Hospital
- Ishida Clinic of IBD and Gastroenterology
- Sai Gastroenterologist Proctology
- Infusion Clinic
- NHO Osaka National Hospital
- Saga-Ken Medical Center Koseikan
- Kumagaya General Hospital
- Matsuda Hospital
- Jichi Medical University Hospital
- Mitsui Memorial Hospital
- Center Hospital of the National Center for Global Health and Medicine
- Juntendo University Hospital
- Tokyo Medical and Dental University Hospital
- Showa University Koto Toyosu Hospital
- Kitasato University Kitasato Institute Hospital
- Kyorin University Hospital
- JHCO Tokyo Yamate Medical Center
- Fukuoka University Hospital
- Hiroshima University Hospital
- Sameshima Hospital
- National Hospital Organization Kyoto Medical Center
- Okayama University Hospital
- Tokitokai Tokito Clinic
- Toyama Prefectural Central Hospital
- Severance Hospital, Yonsei University Health System
- Kyung Hee University Hospital
- Dong-A University Hospital
- Kangbuk Samsung Hospital
- Asan Medical Center
- Samsung Medical Center
- The Catholic University of Korea, Daejeon St. Mary's Hospital
- Inje University Haeundae Paik Hospital
- Yeungnam Univeristy Medical Center
- Pauls Stradins Clinical Univeristy Hospital
- Digestive Diseases Center "Gastro"
- Riga Eastern Clinical University Hospital
- Respublikine Panevezio ligonine
- Hospital of Lithuanian University of Health Sciences Kaunas
- Republic Hospital of Klaipeda
- Klaipeda Seamen's Hospital
- Vilnius University Hospital Santariskiu Clinics
- Universiti Sains Malaysia
- University Malaya Medical Centre
- Hospital Ampang
- Centro de Investigación Clínica Acelerada
- Investigación Biomédica para el Desarrollo de Fármacos S.A. de C.V.
- Centro Para el Desarrollo de la Medicina y de Asistencia Med
- Scientia Investigacion Clinica S.C.
- Sociedad de Metabolismo y Corazon
- St Elisabeth Ziekenhuis
- Amsterdam UMC, locatie AMC
- Bernhoven Ziekenhuis
- UMC Utrecht, Dept. of Internal Medicine, MDL
- LexMedica
- Szpital Uniwersytecki Nr 2 w Bydgoszczy
- Centrum Medyczne Pratia Bydgoszcz
- ZOZ Gastromed
- Samodzielny Publiczny Szpital Kliniczny nr 4 w Lublinie
- NZOZ Vivamed
- Topolowa Medicenter
- Medicenter Nowy Targ
- NZOZ Formed
- Endoskopia Sp. z.o.o.
- SONOMED Centrum Medyczne
- All-Medicus
- Wojewodzki Specjalistyczny Szpital w Olsztynie
- Twoja Przychodnia - Szczecinskie Centrum Medyczne
- Gastromed Kopoń Zmudziński I Wspólnicy Spółka Jawna Specjalistyczne Centrum Gastrologii I Endoskopii
- Warsaw IBD Point Profesor Kierkus
- Centrum Zdrowia MDM
- Centrum Medyczne NeuroProtect
- PlanetMed Sp.z o.o.
- ETG Zamość
- Promedica Dental Clinic
- KO-Med Centrum Medyczne
- CCBR Clinical Research
- MedLife Grivita
- Spitalul Clinic Colentina
- Institutul Clinic Fundeni
- Hifu Terramed Conformal SRL
- Spital Pelican Oradea
- Scientific Centre of Reconstructive and Restorative Surgery
- Karelia Republican Hospital V.A. Baranova
- Nizhny Novgorod Regional Hospital N.A. Semashko
- Private Healthcare Institution Clinical Hospital Russian Railways - Medicine of Nizhniy Novgorod
- Novosibirski Gastrocenter
- Rostov State Medical University
- Scientific research center ECO-security
- Multidisciplinary Medical Clinic "Anthurium"
- Medical and Sanitary Division of Severstal
- LLC MA New Hospital
- Alliance Biomedical URAL Group
- Clinical Trials Center of Medical Institute
- State Autonomous Institution of Healthcare "Republican Clinical Hospital of the Ministry of Healthcare of Republic Tatarstan"
- SIH Kemerovo Regional Clinical Hosptial
- Medical rehabilitation center
- LLC "Medicine Center SibNovoMed"
- Clinical Diagnostic Center Ultramed
- Saint Petersburg State Medical University n.a. Pavlov I.P.
- Pokrovskaya Municipal Hospital
- Non-state Healthcare Institution "Roadway Clinical Hospital of OJSC Russian Railways"
- SBIH City Clinical Hospital #31
- Medical Institute REAVIZ
- City Mariinskaya Hospital
- Stavropol State Medical University
- Yaroslavl Municipal HI Clinical Hospital #8
- Clinical Hospital Center Zvezdara
- University Medical Center "Bezanijska kosa"
- Regional Hospital Dr Radivoj Simonovic Sombor
- Sremska Mitrovica Health Centre
- General Hospital "Djordje Joanovic"
- Clinical Center Kragujevac Gastroenterohepatology Clinic
- KM Management
- Gastro
- Endomed, s.r.o.
- Fakultna nemocnica s poliklinikou Roosevelta Banska Bystrica
- Univerzitna nemocnica Bratislava
- Hospital Universitario Virgen Del Rocio
- Hospital Universitario Central de Asturias
- Hospital Universitari Son Espases
- Hospital Universitario Marqués de Valdecilla
- Hospital De Fuenlabrada
- Hospital Gen. Juan Ramon Jimenez - Depto de Digestivo
- Instituto de Ciencias Médicas
- Hospital Universitari de Girona
- Hospital Universitario Juan Ramon Jimenez
- Complexo Hospitalario Universitario A Coruña, CHUAC
- Hospital De Gran Canaria Dr. Negrin
- Hospital Universitario La Paz
- Gastroenterologische Praxis Balsiger, Seibold & Partner
- Inselspital Bern
- Kantonsspital St.Gallen
- UniversitätsSpital Zürich
- China Medical University Hospital
- Health management center
- Antalya Egitim ve Arastırma Hastanesi
- Acibadem Universitesi - Acibadem Kozyatagi Hastanesi
- Kocaeli University Medical Faculty Hospital
- Mersin University Medical Faculty
- Ege University Medicine of Faculty
- Ivano-Frankivsk Regional Clinical Hospital
- City Clinical Hospital No. 2
- Kherson City Clinical Hospital
- Medical Center of Limited Liability Company "Medical Center "Consilium Medical"
- Lviv Railway Clinical Hospital
- Lviv Regional Endocrinology Dispensary
- Municipal Non-Profit Enterprise "Lviv Clinical Emergency Care Hospital"
- Poltova Oblast Clinical Hospital IM.M.V.Sklifosovskoho
- Diaservis - Medical and Diagnostic Center
- Kharkiv City Student Hospital
- GI L.T. Malaya TI Namsu
- Treatment-Diagnostic Center of Private Enterprise of PPC Atsynus
- Kyiv Municipal Clinical Hospital #1
- Communal institution of the Kyiv Regional Council "Kyiv Regional Clinical Oncology Dispensary"
- Communal institution of the Kyiv Regional Council "Kyiv Regional Clinical Oncology Dispensary"
- Communal Enterprise "Odesa Regional Clinical Hospital"
- A. Novak Transcarpathian Regional Clinical Hospital
- Vinnytsia RCH of Veterans of War Dept of Therapy#1 Vinnytsia M.I.Pyrogov NMU
- MCIC MC LLC Health Clinic
- CCH #1 Vinnytsia M.I. Pyrogov NMU Ch of Propaedeutics of IM
- M.I. Pyrogov Regional Clinical Hospital
- Communal Institution of Kyiv Regional Council Kyiv Regional Hospital #2
- Queens Hospital
- Fairfield General Hospital
- St Thomas' Hospital
- Whipps Cross University Hospital
- Morriston Hospital
- St James's University Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Arm Type
Placebo Comparator
Experimental
Other
Other
Other
Other
Arm Label
Maintenance Period: Miri Induction Responder (IR) - Placebo (PBO) Subcutaneous (SC)
Maintenance Period: Miri IR - 200 Milligram (mg) Miri SC
Maintenance Period: PBO IR - PBO SC
Loss of Response (LOR) Rescue Period:LOR Cohort-300 mg Miri IV
Extended Induction: Induction Nonresponders - 300mg Miri IV
Open Label Maintenance: Delayed Responders - 200 mg Miri SC
Arm Description
Participants who were responders to blinded mirikizumab (miri) at Week 12 in induction study (LUCENT-1) randomized to withdraw from mirikizumab and start receiving PBO SC every 4 weeks (Q4W) from Week 0 of maintenance study (LUCENT-2) until Week 40 or until loss of response was confirmed.
Participants who were responders to blinded mirikizumab at Week 12 in induction study (LUCENT-1) randomized to continue to receive 200 mg mirikizumab SC Q4W from Week 0 of LUCENT-2 until Week 40 or until loss of response was confirmed.
Participants who were responders to blinded placebo at Week 12 in induction study (LUCENT-1) continue to receive blinded placebo SC Q4W from Week 0 of LUCENT-2 until Week 40 or until loss of response was confirmed.
Participants who received PBO SC or 200 mg mirikizumab SC Q4W during maintenance period and experienced a loss of response at or after Week 12, received rescue therapy with open label 300 mg mirikizumab intravenous (IV) Q4W for 3 doses.
Participants who were nonresponders to blinded mirikizumab or placebo in induction study (LUCENT-1), received additional 3 doses of open label 300 mg mirikizumab IV Q4W during extended induction period from Week 0 of LUCENT-2 until Week 12.
Participants who initially did not respond to induction study (LUCENT-1), but responded to extended induction therapy at Week 12 of LUCENT-2 (delayed responders), received 200 mg mirikizumab SC Q4W during open label maintenance period from Week 12 until Week 40.
Outcomes
Primary Outcome Measures
Percentage of Participants in Clinical Remission at Week 40
Clinical remission at week 40 is defined as achieving a 9-point modified Mayo score for rectal bleeding=0, stool frequency=0 or 1 with ≥ 1 point decrease from baseline, and endoscopy=0 or 1 (excluding friability).
Stool Frequency Subscore, based on the participant's diary and scored from 0 (normal number of stools) to 3 (5 or more stools than normal); Rectal Bleeding Subscore, based on the participant's diary and scored from 0 (no blood) to 3 (blood only passed); Endoscopy Subscore, based on central reading of colonoscopy or sigmoidoscopy and scored from 0 (normal or inactive disease) to 3 (severe disease, spontaneous bleeding, ulceration).
Secondary Outcome Measures
Percentage of Participants in Endoscopic Remission at Week 40
Endoscopic remission at week 40 is defined as achieving a Mayo endoscopic subscore of 0 or 1 (excluding friability) at Week 40. Endoscopy subscore is based on colonoscopy or sigmoidoscopy and scored from 0 (normal or inactive disease) to 3 (severe disease, spontaneous bleeding, ulceration).
Percentage of Participants With Histologic Remission at Week 40
Histologic remission was assessed using the Geboes histologic scoring system developed for assessment of histologic disease activity in ulcerative colitis. Remission was defined as Geboes histological subscore of 0 for grades: 2b (lamina propria neutrophils), and 3 (neutrophils in epithelium), and 4 (crypt destruction), and 5 (erosion or ulceration).
Percentage of Participants in Symptomatic Remission at Week 40
Symptomatic remission at week 40 is defined as a Mayo score for rectal bleeding=0, stool frequency=0 or 1 with ≥ 1 point decrease from baseline.
Stool frequency subscore, based on the participant's diary and scored from 0 (normal number of stools) to 3 (5 or more stools than normal).
Rectal bleeding subscore, based on the participant's diary and scored from 0 (no blood seen) to 3 (blood alone passed).
Percentage of Participants in Endoscopic Response at Week 40
Endoscopic response at week 40 is defined as achieving at least a 1 point decrease from baseline in the Mayo endoscopic subscore.
Percentage of Participants in Clinical Response at Week 40
Clinical response at week 40 is defined as a decrease in the 9-point modified Mayo score (MMS) [rectal bleeding, stool frequency and the endoscopic findings] inclusive of >= 2 points and >=30% from baseline with either a decrease of rectal bleeding subscore of >=1 or rectal bleeding subscore of 0 or 1.The MMS is a composite score of ulcerative colitis disease activity calculated as the sum of three subscores: Stool frequency subscore, based on the participant's diary and scored from 0 (normal number of stools) to 3 (5 or more stools than normal); Rectal bleeding subscore, based on the participant's diary and scored from 0 (no blood seen) to 3 (blood alone passed); Endoscopy subscore, based on colonoscopy or sigmoidoscopy and scored from 0 (normal or inactive disease) to 3 (severe disease, spontaneous bleeding,ulceration).
Change From Baseline to Week 40 in Health Related Quality of Life: Inflammatory Bowel Disease Questionnaire (IBDQ) Total Score
The IBDQ is a 32-item participant-completed questionnaire that measures 4 aspects of subjects' lives: symptoms directly related to the primary bowel disturbance, systemic symptoms, emotional function, and social function. Responses are graded on a 7-point. Likert scale in which 7 denotes "not a problem at all" and 1 denotes "a very severe problem." Scores range from 32 to 224; a higher score indicates a better quality of life. Least square (LS) Mean was calculated using analysis of covariance (ANCOVA) model for post-baseline measures: The ANCOVA model includes: treatment, baseline value, prior biologic or tofacitinib failure (yes/no), clinical remission status (yes/no) at AMAN Week 12, and region (North America/Europe/Other).
Change From Baseline to Week 40 in Fecal Calprotectin
Fecal calprotectin is an indicator of inflammation in the colon with higher levels indicative of higher levels of inflammation. Least square (LS) Mean was calculated using ANCOVA model for post-baseline measures: The ANCOVA model includes treatment, baseline value, prior biologic or tofacitinib failure (yes/no), corticosteroid use (yes/no) at AMAN baseline, region (North America/Europe/Other), Clinical Remission status (yes/no) at AMAN Week 12.
Change From Baseline to Week 40 in Bowel Urgency Based on the Urgency Numeric Rating Scale (NRS)
The Urgency NRS is a single participant reported item that measures the severity for the urgency (sudden or immediate need) to have a bowel movement in the past 24 hours using an 11-point NRS ranging from 0 (no urgency) to 10 (worst possible urgency). Higher scores indicate more severe urgency. Least square (LS) Mean was calculated using mixed model repeated measures (MMRM) model for post-baseline measures: The MMRM model includes treatment, baseline value, visit, interaction of baseline value-by-visit, interaction of treatment-by-visit, prior biologic or tofacitinib failure (yes/no), baseline corticosteroid use (yes/no), clinical remission status (yes/no) at AMAN Week 12, and region (North America/Europe/Other).
Percentage of Participants Hospitalized for Ulcerative Colitis (UC)
Percentage of participants hospitalized for UC. Only hospitalizations associated with an adverse event with >=24 hours stay were recorded.
Pharmacokinetics (PK): Clearance of Mirikizumab
Clearance of mirikizumab was evaluated.
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT03524092
Brief Title
A Maintenance Study of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis
Acronym
LUCENT 2
Official Title
A Phase 3, Multicenter, Randomized, Double-Blind, Parallel-Arm, Placebo-Controlled Maintenance Study of Mirikizumab in Patients With Moderately to Severely Active Ulcerative Colitis (LUCENT 2)
Study Type
Interventional
2. Study Status
Record Verification Date
October 2023
Overall Recruitment Status
Active, not recruiting
Study Start Date
October 19, 2018 (Actual)
Primary Completion Date
November 3, 2021 (Actual)
Study Completion Date
June 29, 2025 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Eli Lilly and Company
4. Oversight
Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
The purpose of this study is to evaluate the efficacy and safety of mirikizumab as maintenance therapy in participants who completed as clinical responders in the prior 12-week induction study LUCENT-1 (NCT03518086).
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Ulcerative Colitis
Keywords
Interleukin-23 (IL-23), IL-23p19, Inflammatory Bowel Disease
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantInvestigator
Allocation
Randomized
Enrollment
1177 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Maintenance Period: Miri Induction Responder (IR) - Placebo (PBO) Subcutaneous (SC)
Arm Type
Placebo Comparator
Arm Description
Participants who were responders to blinded mirikizumab (miri) at Week 12 in induction study (LUCENT-1) randomized to withdraw from mirikizumab and start receiving PBO SC every 4 weeks (Q4W) from Week 0 of maintenance study (LUCENT-2) until Week 40 or until loss of response was confirmed.
Arm Title
Maintenance Period: Miri IR - 200 Milligram (mg) Miri SC
Arm Type
Experimental
Arm Description
Participants who were responders to blinded mirikizumab at Week 12 in induction study (LUCENT-1) randomized to continue to receive 200 mg mirikizumab SC Q4W from Week 0 of LUCENT-2 until Week 40 or until loss of response was confirmed.
Arm Title
Maintenance Period: PBO IR - PBO SC
Arm Type
Other
Arm Description
Participants who were responders to blinded placebo at Week 12 in induction study (LUCENT-1) continue to receive blinded placebo SC Q4W from Week 0 of LUCENT-2 until Week 40 or until loss of response was confirmed.
Arm Title
Loss of Response (LOR) Rescue Period:LOR Cohort-300 mg Miri IV
Arm Type
Other
Arm Description
Participants who received PBO SC or 200 mg mirikizumab SC Q4W during maintenance period and experienced a loss of response at or after Week 12, received rescue therapy with open label 300 mg mirikizumab intravenous (IV) Q4W for 3 doses.
Arm Title
Extended Induction: Induction Nonresponders - 300mg Miri IV
Arm Type
Other
Arm Description
Participants who were nonresponders to blinded mirikizumab or placebo in induction study (LUCENT-1), received additional 3 doses of open label 300 mg mirikizumab IV Q4W during extended induction period from Week 0 of LUCENT-2 until Week 12.
Arm Title
Open Label Maintenance: Delayed Responders - 200 mg Miri SC
Arm Type
Other
Arm Description
Participants who initially did not respond to induction study (LUCENT-1), but responded to extended induction therapy at Week 12 of LUCENT-2 (delayed responders), received 200 mg mirikizumab SC Q4W during open label maintenance period from Week 12 until Week 40.
Intervention Type
Drug
Intervention Name(s)
Mirikizumab SC
Other Intervention Name(s)
LY3074828
Intervention Description
Administered SC
Intervention Type
Drug
Intervention Name(s)
Mirikizumab IV
Other Intervention Name(s)
LY3074828
Intervention Description
Administered IV
Intervention Type
Drug
Intervention Name(s)
Placebo SC
Intervention Description
Administered SC
Primary Outcome Measure Information:
Title
Percentage of Participants in Clinical Remission at Week 40
Description
Clinical remission at week 40 is defined as achieving a 9-point modified Mayo score for rectal bleeding=0, stool frequency=0 or 1 with ≥ 1 point decrease from baseline, and endoscopy=0 or 1 (excluding friability).
Stool Frequency Subscore, based on the participant's diary and scored from 0 (normal number of stools) to 3 (5 or more stools than normal); Rectal Bleeding Subscore, based on the participant's diary and scored from 0 (no blood) to 3 (blood only passed); Endoscopy Subscore, based on central reading of colonoscopy or sigmoidoscopy and scored from 0 (normal or inactive disease) to 3 (severe disease, spontaneous bleeding, ulceration).
Time Frame
Week 40
Secondary Outcome Measure Information:
Title
Percentage of Participants in Endoscopic Remission at Week 40
Description
Endoscopic remission at week 40 is defined as achieving a Mayo endoscopic subscore of 0 or 1 (excluding friability) at Week 40. Endoscopy subscore is based on colonoscopy or sigmoidoscopy and scored from 0 (normal or inactive disease) to 3 (severe disease, spontaneous bleeding, ulceration).
Time Frame
Week 40
Title
Percentage of Participants With Histologic Remission at Week 40
Description
Histologic remission was assessed using the Geboes histologic scoring system developed for assessment of histologic disease activity in ulcerative colitis. Remission was defined as Geboes histological subscore of 0 for grades: 2b (lamina propria neutrophils), and 3 (neutrophils in epithelium), and 4 (crypt destruction), and 5 (erosion or ulceration).
Time Frame
Week 40
Title
Percentage of Participants in Symptomatic Remission at Week 40
Description
Symptomatic remission at week 40 is defined as a Mayo score for rectal bleeding=0, stool frequency=0 or 1 with ≥ 1 point decrease from baseline.
Stool frequency subscore, based on the participant's diary and scored from 0 (normal number of stools) to 3 (5 or more stools than normal).
Rectal bleeding subscore, based on the participant's diary and scored from 0 (no blood seen) to 3 (blood alone passed).
Time Frame
Week 40
Title
Percentage of Participants in Endoscopic Response at Week 40
Description
Endoscopic response at week 40 is defined as achieving at least a 1 point decrease from baseline in the Mayo endoscopic subscore.
Time Frame
Week 40
Title
Percentage of Participants in Clinical Response at Week 40
Description
Clinical response at week 40 is defined as a decrease in the 9-point modified Mayo score (MMS) [rectal bleeding, stool frequency and the endoscopic findings] inclusive of >= 2 points and >=30% from baseline with either a decrease of rectal bleeding subscore of >=1 or rectal bleeding subscore of 0 or 1.The MMS is a composite score of ulcerative colitis disease activity calculated as the sum of three subscores: Stool frequency subscore, based on the participant's diary and scored from 0 (normal number of stools) to 3 (5 or more stools than normal); Rectal bleeding subscore, based on the participant's diary and scored from 0 (no blood seen) to 3 (blood alone passed); Endoscopy subscore, based on colonoscopy or sigmoidoscopy and scored from 0 (normal or inactive disease) to 3 (severe disease, spontaneous bleeding,ulceration).
Time Frame
Week 40
Title
Change From Baseline to Week 40 in Health Related Quality of Life: Inflammatory Bowel Disease Questionnaire (IBDQ) Total Score
Description
The IBDQ is a 32-item participant-completed questionnaire that measures 4 aspects of subjects' lives: symptoms directly related to the primary bowel disturbance, systemic symptoms, emotional function, and social function. Responses are graded on a 7-point. Likert scale in which 7 denotes "not a problem at all" and 1 denotes "a very severe problem." Scores range from 32 to 224; a higher score indicates a better quality of life. Least square (LS) Mean was calculated using analysis of covariance (ANCOVA) model for post-baseline measures: The ANCOVA model includes: treatment, baseline value, prior biologic or tofacitinib failure (yes/no), clinical remission status (yes/no) at AMAN Week 12, and region (North America/Europe/Other).
Time Frame
Induction Baseline, Week 40
Title
Change From Baseline to Week 40 in Fecal Calprotectin
Description
Fecal calprotectin is an indicator of inflammation in the colon with higher levels indicative of higher levels of inflammation. Least square (LS) Mean was calculated using ANCOVA model for post-baseline measures: The ANCOVA model includes treatment, baseline value, prior biologic or tofacitinib failure (yes/no), corticosteroid use (yes/no) at AMAN baseline, region (North America/Europe/Other), Clinical Remission status (yes/no) at AMAN Week 12.
Time Frame
Induction Baseline, Week 40
Title
Change From Baseline to Week 40 in Bowel Urgency Based on the Urgency Numeric Rating Scale (NRS)
Description
The Urgency NRS is a single participant reported item that measures the severity for the urgency (sudden or immediate need) to have a bowel movement in the past 24 hours using an 11-point NRS ranging from 0 (no urgency) to 10 (worst possible urgency). Higher scores indicate more severe urgency. Least square (LS) Mean was calculated using mixed model repeated measures (MMRM) model for post-baseline measures: The MMRM model includes treatment, baseline value, visit, interaction of baseline value-by-visit, interaction of treatment-by-visit, prior biologic or tofacitinib failure (yes/no), baseline corticosteroid use (yes/no), clinical remission status (yes/no) at AMAN Week 12, and region (North America/Europe/Other).
Time Frame
Induction Baseline, Week 40
Title
Percentage of Participants Hospitalized for Ulcerative Colitis (UC)
Description
Percentage of participants hospitalized for UC. Only hospitalizations associated with an adverse event with >=24 hours stay were recorded.
Time Frame
Week 40
Title
Pharmacokinetics (PK): Clearance of Mirikizumab
Description
Clearance of mirikizumab was evaluated.
Time Frame
Predose: Weeks 0, 4, 12, 24 and 40
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
80 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Have completed Study AMAN (NCT03518086), with at least 1 study drug administration and without early termination of study drug.
Are willing and able to complete the scheduled study assessments, including endoscopy and daily diary entry.
If female, must meet the contraception requirements.
Exclusion Criteria:
Participants diagnosed with Crohn's disease or inflammatory bowel disease-unclassified (indeterminate colitis) during the induction study AMAN (NCT03518086).
Participants with a bowel resection or other surgery for the treatment of UC during the previous induction study AMAN (NCT03518086), or are likely to require surgery for the treatment of UC during study AMBG.
Participants with evidence of colonic dysplasia or have been diagnosed with cancer of the gastrointestinal tract during study AMAN (NCT03518086).
Participants diagnosed with clinically important infection including, but not limited to, hepatitis B, hepatitis C, HIV/AIDS, and active tuberculosis (TB) during the induction study AMAN (NCT03518086).
Participants who initiate a new prohibited medication during the induction study AMAN (NCT03518086).
Participants with certain laboratory abnormalities prior to start of AMBG that would require permanent discontinuation from study drug.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)
Organizational Affiliation
Eli Lilly and Company
Official's Role
Study Director
Facility Information:
Facility Name
Digestive Health Specialists
City
Dothan
State/Province
Alabama
ZIP/Postal Code
36305
Country
United States
Facility Name
Dcr-Pi, Pc
City
Litchfield Park
State/Province
Arizona
ZIP/Postal Code
85340
Country
United States
Facility Name
Maricopa Integrated Health System
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85008
Country
United States
Facility Name
Physicians Research Group
City
Tempe
State/Province
Arizona
ZIP/Postal Code
85284
Country
United States
Facility Name
Valley Gastroenterology
City
Arcadia
State/Province
California
ZIP/Postal Code
91006
Country
United States
Facility Name
Care Access Research
City
Berkeley
State/Province
California
ZIP/Postal Code
94705
Country
United States
Facility Name
Om Research, LLC
City
Lancaster
State/Province
California
ZIP/Postal Code
93534
Country
United States
Facility Name
California Medical Research Associates
City
Northridge
State/Province
California
ZIP/Postal Code
91324
Country
United States
Facility Name
Clinical Applications Laboratories, Inc.
City
San Diego
State/Province
California
ZIP/Postal Code
92103
Country
United States
Facility Name
UCSF Medical Center at Mission Bay
City
San Francisco
State/Province
California
ZIP/Postal Code
94158
Country
United States
Facility Name
Direct Helpers Research Center
City
Hialeah
State/Province
Florida
ZIP/Postal Code
33012
Country
United States
Facility Name
Nature Coast Clinical Research, LLC
City
Inverness
State/Province
Florida
ZIP/Postal Code
34452
Country
United States
Facility Name
SIH Research, LLC
City
Kissimmee
State/Province
Florida
ZIP/Postal Code
34741
Country
United States
Facility Name
Wellness Clinical Research
City
Miami Lakes
State/Province
Florida
ZIP/Postal Code
33016
Country
United States
Facility Name
Columbus Clinical Services, LLC
City
Miami
State/Province
Florida
ZIP/Postal Code
33125
Country
United States
Facility Name
Research Associates of South Florida, LLC
City
Miami
State/Province
Florida
ZIP/Postal Code
33134
Country
United States
Facility Name
Center for Interventional Endoscopy
City
Orlando
State/Province
Florida
ZIP/Postal Code
32803
Country
United States
Facility Name
Clintheory Healthcare
City
Orlando
State/Province
Florida
ZIP/Postal Code
32818
Country
United States
Facility Name
Gastroenterology Associates of Pensacola, PA
City
Pensacola
State/Province
Florida
ZIP/Postal Code
32503
Country
United States
Facility Name
Florida Digestive Specialist
City
Saint Petersburg
State/Province
Florida
ZIP/Postal Code
33709
Country
United States
Facility Name
Florida Medical Clinic LLC
City
Zephyrhills
State/Province
Florida
ZIP/Postal Code
33542-7505
Country
United States
Facility Name
Digestive Healthcare of Georgia
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30309
Country
United States
Facility Name
Grand Teton Research Group
City
Idaho Falls
State/Province
Idaho
ZIP/Postal Code
83404
Country
United States
Facility Name
NorthShore University HealthSystem
City
Evanston
State/Province
Illinois
ZIP/Postal Code
60201
Country
United States
Facility Name
Indiana University School of Medicine
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46202
Country
United States
Facility Name
Cotton-O'Neil Clinical Research Center, Digestive Health
City
Topeka
State/Province
Kansas
ZIP/Postal Code
66606
Country
United States
Facility Name
Texas Digestive Disease Consultants
City
Baton Rouge
State/Province
Louisiana
ZIP/Postal Code
70809
Country
United States
Facility Name
Delta Research Partners LLC
City
Monroe
State/Province
Louisiana
ZIP/Postal Code
71201
Country
United States
Facility Name
Nola Research Works, LLC
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70125
Country
United States
Facility Name
Clinical Research Institute of Michigan, LLC
City
Chesterfield
State/Province
Michigan
ZIP/Postal Code
48047
Country
United States
Facility Name
Henry Ford Health System
City
Novi
State/Province
Michigan
ZIP/Postal Code
48377
Country
United States
Facility Name
Gastroenterology Associates of Western Michigan, P.L.C.
City
Wyoming
State/Province
Michigan
ZIP/Postal Code
49519
Country
United States
Facility Name
Huron Gastroenterology Associates
City
Ypsilanti
State/Province
Michigan
ZIP/Postal Code
48197
Country
United States
Facility Name
MNGI Digestive Health - Plymouth Endoscopy Center & Clinic
City
Plymouth
State/Province
Minnesota
ZIP/Postal Code
55446
Country
United States
Facility Name
Gen1 Research - Gastroenterology & Nutrition, PC
City
Forest Hills
State/Province
New York
ZIP/Postal Code
11375
Country
United States
Facility Name
Northwell Health
City
Great Neck
State/Province
New York
ZIP/Postal Code
11021
Country
United States
Facility Name
Weill Cornell Medical College
City
New York
State/Province
New York
ZIP/Postal Code
10021
Country
United States
Facility Name
University of North Carolina Center for Inflammatory Bowel Disease
City
Chapel Hill
State/Province
North Carolina
ZIP/Postal Code
27599
Country
United States
Facility Name
Carolina Digestive Diseases and Endoscopy Center
City
Greenville
State/Province
North Carolina
ZIP/Postal Code
27834
Country
United States
Facility Name
Paramount Medical Research
City
Middleburg Heights
State/Province
Ohio
ZIP/Postal Code
44130
Country
United States
Facility Name
Care Access - Youngstown
City
Poland
State/Province
Ohio
ZIP/Postal Code
44514
Country
United States
Facility Name
Central Sooner Research
City
Norman
State/Province
Oklahoma
ZIP/Postal Code
73071
Country
United States
Facility Name
University of Oklahoma Health Sciences Center
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73104
Country
United States
Facility Name
Care Access Research LLC
City
Pottsville
State/Province
Pennsylvania
ZIP/Postal Code
17901
Country
United States
Facility Name
Digestive Disease Associates
City
Wyomissing
State/Province
Pennsylvania
ZIP/Postal Code
19610
Country
United States
Facility Name
Midwest Medical Care
City
Sioux Falls
State/Province
South Dakota
ZIP/Postal Code
57108
Country
United States
Facility Name
Gastro One
City
Germantown
State/Province
Tennessee
ZIP/Postal Code
38138
Country
United States
Facility Name
Galen Medical Group
City
Hixson
State/Province
Tennessee
ZIP/Postal Code
37343
Country
United States
Facility Name
Digestive Health Associates of Texas
City
Garland
State/Province
Texas
ZIP/Postal Code
75044
Country
United States
Facility Name
Houston Methodist Research Ins
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Biopharma Informatic, LLC
City
Houston
State/Province
Texas
ZIP/Postal Code
77084
Country
United States
Facility Name
Gastroenterology Research of San Antonio
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229
Country
United States
Facility Name
Southern Star Research Institute, LLC
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229
Country
United States
Facility Name
Texas Digestive Disease Consultants
City
Southlake
State/Province
Texas
ZIP/Postal Code
76092
Country
United States
Facility Name
Care Access Research LLC - Salt Lake City
City
Ogden
State/Province
Utah
ZIP/Postal Code
84403
Country
United States
Facility Name
Emeritas Research Group
City
Leesburg
State/Province
Virginia
ZIP/Postal Code
20176
Country
United States
Facility Name
The Gastroenterology Group, P.C.
City
Reston
State/Province
Virginia
ZIP/Postal Code
20191
Country
United States
Facility Name
Carilion Clinic
City
Roanoke
State/Province
Virginia
ZIP/Postal Code
24016
Country
United States
Facility Name
Digestive Health Specialists
City
Tacoma
State/Province
Washington
ZIP/Postal Code
98405
Country
United States
Facility Name
Wisconsin Center for Advanced Research
City
Milwaukee
State/Province
Wisconsin
ZIP/Postal Code
53215
Country
United States
Facility Name
Centro de Investigaciones Metabólicas (CINME)
City
Caba
State/Province
Buenos Aires
ZIP/Postal Code
C1027AAP
Country
Argentina
Facility Name
Mautalen Salud e Investigacion-Centro de Osteopatías Médicas
City
Ciudad Autonoma De Buenos Air
State/Province
Buenos Aires
ZIP/Postal Code
C1128AAF
Country
Argentina
Facility Name
CER Instituto Medico
City
Quilmes
State/Province
Buenos Aires
ZIP/Postal Code
B1878DVC
Country
Argentina
Facility Name
Fundación de Estudios Clínicos
City
Rosario
State/Province
Santa Fe
ZIP/Postal Code
S2000DEJ
Country
Argentina
Facility Name
Centro de Investigaciones Médicas Tucuman
City
SAN M. DE Tucuman
State/Province
Tucumán
ZIP/Postal Code
T4000AXL
Country
Argentina
Facility Name
C.I.C.E. 9 de Julio
City
San Miguel de Tucumán
State/Province
Tucumán
ZIP/Postal Code
4000
Country
Argentina
Facility Name
Hospital Privado Centro Medico de Cordoba SA
City
Cordoba
ZIP/Postal Code
X5016KEH
Country
Argentina
Facility Name
Princess Alexandra Hospital
City
Brisbane
State/Province
Queensland
ZIP/Postal Code
4102
Country
Australia
Facility Name
Coastal Digestive Health
City
Maroochydore
State/Province
Queensland
ZIP/Postal Code
4558
Country
Australia
Facility Name
Mater University Hospital
City
South Brisbane
State/Province
Queensland
ZIP/Postal Code
4101
Country
Australia
Facility Name
Royal Adelaide Hospital
City
Adelaide
State/Province
South Australia
ZIP/Postal Code
5000
Country
Australia
Facility Name
Box Hill Hospital Outpatients
City
Box Hill
State/Province
Victoria
ZIP/Postal Code
3128
Country
Australia
Facility Name
Melbourne Gastrointestinal Investigation Unit (MGIU)
City
Malvern
State/Province
Victoria
ZIP/Postal Code
3144
Country
Australia
Facility Name
The Alfred Hospital
City
Melbourne
State/Province
Victoria
ZIP/Postal Code
3004
Country
Australia
Facility Name
The Royal Melbourne Hospital
City
Parkville
State/Province
Victoria
ZIP/Postal Code
3050
Country
Australia
Facility Name
Medizinische Universität Innsbruck
City
Innsbruck
ZIP/Postal Code
6020
Country
Austria
Facility Name
Universitätsklinikum Salzburg
City
Salzburg
ZIP/Postal Code
5020
Country
Austria
Facility Name
Medical University of Vienna
City
Vienna
ZIP/Postal Code
1090
Country
Austria
Facility Name
Universitair Ziekenhuis Gent
City
Gent
State/Province
Oost-Vlaanderen
ZIP/Postal Code
9000
Country
Belgium
Facility Name
Centre Hospitalier de Wallonie Picarde - Site Notre Dame
City
Tournai
State/Province
Wallonne, Région
ZIP/Postal Code
7500
Country
Belgium
Facility Name
AZ Klina
City
Brasschaat
ZIP/Postal Code
2930
Country
Belgium
Facility Name
Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg
City
Leuven
ZIP/Postal Code
3000
Country
Belgium
Facility Name
West Edmonton Diabetes Center
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T5R 1W2
Country
Canada
Facility Name
The Gordon and Leslie Diamond Health Care Centre
City
Vancouver
State/Province
British Columbia
ZIP/Postal Code
V5Z 1M9
Country
Canada
Facility Name
GI Research Institute
City
Vancouver
State/Province
British Columbia
ZIP/Postal Code
V6Z 2K5
Country
Canada
Facility Name
PerCuro Clinical Research
City
Victoria
State/Province
British Columbia
ZIP/Postal Code
V8V 3M9
Country
Canada
Facility Name
Victoria Hospital
City
London
State/Province
Ontario
ZIP/Postal Code
N6A 4G5
Country
Canada
Facility Name
University of Western Ontario
City
London
State/Province
Ontario
ZIP/Postal Code
N6A 5G1
Country
Canada
Facility Name
Centre de santé et de services sociaux Champlain-Charles-Le Moyne
City
Greenfield Park
State/Province
Quebec
ZIP/Postal Code
J4V 2H1
Country
Canada
Facility Name
Hopital Maisonneure-Rosemount
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H1T 2M4
Country
Canada
Facility Name
Inflammatory Bowel Disease Centre Montreal General Hospital - MUHC
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H3G 1A4
Country
Canada
Facility Name
Anhui Provincial Hospital
City
Hefei City
State/Province
Anhui
ZIP/Postal Code
230000
Country
China
Facility Name
The First Affiliated Hospital of Anhui Medical University
City
HefeiCity
State/Province
Anhui
ZIP/Postal Code
230022
Country
China
Facility Name
Beijing Friendship Hospital Affiliate of Capital University
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100050
Country
China
Facility Name
Xiangya Hospital Central South University
City
Kaifu District
State/Province
Changsha City
ZIP/Postal Code
410008
Country
China
Facility Name
The Affiliated 2nd Hosp. of Third Military Med. Univ. of PLA
City
Chongqing
State/Province
Chongqing
ZIP/Postal Code
400037
Country
China
Facility Name
The First Hospital Affiliated to AMU (Southwest Hospital)
City
Chongqing
State/Province
Chongqing
ZIP/Postal Code
400038
Country
China
Facility Name
Fujian Province Hospital
City
Fuzhou
State/Province
Fujian
ZIP/Postal Code
350001
Country
China
Facility Name
The Sixth Affiliated Hospital, Sun Yat-Sen University
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510655
Country
China
Facility Name
The University of Hong Kong-Shenzhen Hospital
City
Shenzhen
State/Province
Guangdong
ZIP/Postal Code
518053
Country
China
Facility Name
Hainan General Hospital
City
Haikou
State/Province
Hainan
ZIP/Postal Code
570311
Country
China
Facility Name
Union Hospital Tongji Medical College Huazhong University of Science and Technology
City
Wuhan
State/Province
Hubei
ZIP/Postal Code
430022
Country
China
Facility Name
Renmin Hospital of Wuhan University
City
Wuhan
State/Province
Hubei
ZIP/Postal Code
430060
Country
China
Facility Name
Changzhou No.2 People's Hospital
City
Changzhou
State/Province
Jiangsu
ZIP/Postal Code
213003
Country
China
Facility Name
The Affiliated Drum Tower Hospital of Nanjing University
City
Nanjing
State/Province
Jiangsu
ZIP/Postal Code
210008
Country
China
Facility Name
Jiangsu Province Hospital of Chinese Medicine
City
Nanjing
State/Province
Jiangsu
ZIP/Postal Code
210029
Country
China
Facility Name
Jiangsu Province Hospital
City
Nanjing
State/Province
Jiangsu
ZIP/Postal Code
210029
Country
China
Facility Name
Zhongda Hospital Southeast University
City
Nanjing
State/Province
Jiangsu
ZIP/Postal Code
210029
Country
China
Facility Name
Nanjing Medical University - Nanjing Jiangning Hospital
City
Nanjing
State/Province
Jiangsu
ZIP/Postal Code
211106
Country
China
Facility Name
Jiangxi Pingxiang People's Hospital
City
Pingxiang
State/Province
Jiangxi
ZIP/Postal Code
337055
Country
China
Facility Name
Jilin Central General Hospital
City
Jilin
State/Province
Jilin
ZIP/Postal Code
132011
Country
China
Facility Name
The Second Hospital of Dalian Medical University
City
Dalian
State/Province
Lianing
ZIP/Postal Code
116000
Country
China
Facility Name
Shengjing Hospital of China Medical University
City
Shenyang
State/Province
Liaoning
ZIP/Postal Code
110004
Country
China
Facility Name
Qilu Hospital of Shandong University
City
Jinan
State/Province
Shandong
ZIP/Postal Code
250014
Country
China
Facility Name
Liaocheng People's Hospital
City
Liaocheng
State/Province
Shandong
ZIP/Postal Code
252000
Country
China
Facility Name
The Affiliated Hospital of Medical College Qingdao Univ
City
Qingdao
State/Province
Shandong
ZIP/Postal Code
266000
Country
China
Facility Name
Taian City Central Hospital
City
Taian
State/Province
Shandong
ZIP/Postal Code
271000
Country
China
Facility Name
Shanghai Jiaotong University School of Medicine Ruijin Hospital
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200025
Country
China
Facility Name
Renji Hospital Affliated to Shanghai Jiaotong University
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200127
Country
China
Facility Name
West China Hospital of Sichuan University
City
Chengdu
State/Province
Sichuan
ZIP/Postal Code
610041
Country
China
Facility Name
No.1 Hospital Affiliated to Xinjiang Medical University
City
Urumchi
State/Province
Urumchi
ZIP/Postal Code
830054
Country
China
Facility Name
Kunming Medical College Affiliated First Hospital
City
Kunming
State/Province
Yunnan
ZIP/Postal Code
650032
Country
China
Facility Name
The First People's Hospital of Yunnan Province
City
Kunming
State/Province
Yunnan
ZIP/Postal Code
650034
Country
China
Facility Name
The Second Affiliated Hospital of Zhejiang University School of Med
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310000
Country
China
Facility Name
First Affiliated Hosp of College of Med, Zhejiang University
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310003
Country
China
Facility Name
Sir Run Run Shaw Hospital
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310016
Country
China
Facility Name
The Second Affiliated Hospital YuYing Childens Hospital of Wenzhou Medical university
City
Wenzhou
State/Province
Zhejiang
ZIP/Postal Code
325027
Country
China
Facility Name
Tongji Hospital of Tongji University
City
Wuhan
ZIP/Postal Code
430030
Country
China
Facility Name
Vojenská Nemocnice Brno
City
Brno
State/Province
Brno-město
ZIP/Postal Code
636 00
Country
Czechia
Facility Name
Fakultni nemocnice Kralovske Vinohrady
City
Praha 10
State/Province
Hl. M. Praha
ZIP/Postal Code
100 34
Country
Czechia
Facility Name
Hepato-Gastroenterologie HK
City
Hradec Kralove
State/Province
Hradec Králové
ZIP/Postal Code
500 12
Country
Czechia
Facility Name
MUDr. Gregar, s.r.o.
City
Olomouc
State/Province
Olomoucký Kraj
ZIP/Postal Code
779 00
Country
Czechia
Facility Name
A-Shine
City
Pilsen
State/Province
Plzeň-město
ZIP/Postal Code
312 00
Country
Czechia
Facility Name
MEDIENDO
City
Prague
State/Province
Praha 8
ZIP/Postal Code
186 00
Country
Czechia
Facility Name
Fakultni Nemocnice u sv. Anny v Brne
City
Brno
ZIP/Postal Code
65691
Country
Czechia
Facility Name
PreventaMed, s.r.o.
City
Olomouc
ZIP/Postal Code
779 00
Country
Czechia
Facility Name
ISCARE Clinical Centre
City
Praha 9
ZIP/Postal Code
19000
Country
Czechia
Facility Name
Herlev and Gentofte Hospital
City
Herlev
ZIP/Postal Code
2730
Country
Denmark
Facility Name
Zealand University Hospital Køge
City
Køge
ZIP/Postal Code
4600
Country
Denmark
Facility Name
Hopital de Hautepierre - Service d'Hépatogastroentérolgie
City
Strasbourg Cedex
State/Province
Bas Rhin
ZIP/Postal Code
67098
Country
France
Facility Name
Hopital Saint-Louis
City
Paris
State/Province
Cedex 10
ZIP/Postal Code
75475
Country
France
Facility Name
CHU Lille - Hôpital Claude Huriez
City
Lille cedex
State/Province
Nord
ZIP/Postal Code
59037
Country
France
Facility Name
Hôpital Beaujon
City
Clichy
State/Province
Paris
ZIP/Postal Code
92110
Country
France
Facility Name
Centre Hospitalier de Pau
City
Pau
State/Province
Pyrénées-Atlantiques
ZIP/Postal Code
64000
Country
France
Facility Name
Hospices Civils de Lyon - Centre Hospitalier Lyon Sud -
City
Pierre Benite cedex
State/Province
Rhone
ZIP/Postal Code
69495
Country
France
Facility Name
CHU Amiens Picardie-Site Sud - RDC Service Hépato gastro
City
Amiens Cedex
State/Province
Somme
ZIP/Postal Code
80480
Country
France
Facility Name
CHU Tours - Hôpital Trousseau
City
Chambray les Tours
ZIP/Postal Code
37170
Country
France
Facility Name
Assistance Publique Hôpitaux de Marseille - Hôpital Nord
City
Marseille Cedex 20
ZIP/Postal Code
13915
Country
France
Facility Name
CHRU de Montpellier-Hopital St Eloi
City
Montpellier Cedex 5
ZIP/Postal Code
34295
Country
France
Facility Name
Hopital L'Archet 2
City
Nice Cedex
ZIP/Postal Code
06200
Country
France
Facility Name
CHU Bordeaux - Hôpital Haut-Lévêque
City
Pessac Cedex
ZIP/Postal Code
33604
Country
France
Facility Name
Robert Debre Hospital
City
Reims
ZIP/Postal Code
51092
Country
France
Facility Name
CHU de Saint Etienne Hopital Nord
City
Saint Priest en Jarez
ZIP/Postal Code
42270
Country
France
Facility Name
CHRU Nancy Brabois - Hôpital d'Enfants
City
Vandoeuvre les Nancy
ZIP/Postal Code
54500
Country
France
Facility Name
Medizinische Hochschule Hanover
City
Hannover
State/Province
Niedersachsen
ZIP/Postal Code
30625
Country
Germany
Facility Name
Gemeinschaftspraxis Dr. Peter Uebel
City
Ludwigshafen am Rhein
State/Province
Rheinland-Pfalz
ZIP/Postal Code
67067
Country
Germany
Facility Name
Studiengesellschaft BSF Unternehmergesellschaft
City
Halle (Saale)
State/Province
Sachsen-Anhalt
ZIP/Postal Code
06108
Country
Germany
Facility Name
Universitätsklinikum Halle
City
Halle (Saale)
State/Province
Sachsen-Anhalt
ZIP/Postal Code
06120
Country
Germany
Facility Name
Charité Campus Virchow-Klinikum
City
Berlin
ZIP/Postal Code
12203
Country
Germany
Facility Name
Krankenhaus Waldfriede
City
Berlin
ZIP/Postal Code
14163
Country
Germany
Facility Name
Städtisches Klinikum Brandenburg
City
Brandenburg
ZIP/Postal Code
14770
Country
Germany
Facility Name
HaFCED - Hamburgisches Forschungsinstitut für chronisch entzündliche Darmerkrankungen
City
Hamburg
ZIP/Postal Code
20251
Country
Germany
Facility Name
Internistische Praxisgemeinschaft
City
Weyhe
ZIP/Postal Code
28844
Country
Germany
Facility Name
DRC Gyogyszervizsgalo Kozpont Kft.
City
Balatonfüred
State/Province
EU
ZIP/Postal Code
8230
Country
Hungary
Facility Name
Jávorszky Ödön Kórház
City
Vác
State/Province
Pest
ZIP/Postal Code
2600
Country
Hungary
Facility Name
Óbudai Egészségügyi Centrum
City
Budapest
ZIP/Postal Code
1036
Country
Hungary
Facility Name
Semmelweis Egyetem
City
Budapest
ZIP/Postal Code
1088
Country
Hungary
Facility Name
Debreceni Egyetem Klinikai Kozpont
City
Debrecen
ZIP/Postal Code
4032
Country
Hungary
Facility Name
Endomedix Diagnosztikai Központ - Miskolc
City
Miskolc
ZIP/Postal Code
3526
Country
Hungary
Facility Name
Karolina Korhaz-Rendelointezet
City
Mosonmagyarovar
ZIP/Postal Code
9200
Country
Hungary
Facility Name
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont I. Belgyogyaszati Klinika
City
Szeged
ZIP/Postal Code
6720
Country
Hungary
Facility Name
CLINFAN Szolgáltató Kft
City
Szekszard
ZIP/Postal Code
7100
Country
Hungary
Facility Name
Centre for Liver Research & Diagnostics, Deccan College of Medical Sciences, Owaisi Hospital & Research Centre
City
Hyderabad
State/Province
Andhra Pradesh
ZIP/Postal Code
500058
Country
India
Facility Name
Escorts Heart Institute and Research Centre Ltd
City
New Delhi
State/Province
Delhi
ZIP/Postal Code
110 025
Country
India
Facility Name
Apollo Research and Innovations, Apollo Hospitals International Ltd
City
Gandhinagar
State/Province
Gujarat
ZIP/Postal Code
382428
Country
India
Facility Name
Shree Giriraj Multispeciality Hospital
City
Rajkot
State/Province
Gujarat
ZIP/Postal Code
360005
Country
India
Facility Name
Nirmal Hospital Pvt Ltd.
City
Surat
State/Province
Gujarat
ZIP/Postal Code
395002
Country
India
Facility Name
Bangalore Medical College and Research Institute
City
Bangalore
State/Province
Karnataka
ZIP/Postal Code
560 002
Country
India
Facility Name
M S Ramaiah Medical College and Hospitals
City
Bangalore
State/Province
Karnataka
ZIP/Postal Code
560054
Country
India
Facility Name
Midas Multispeciality Hospital Pvt.Ltd.
City
Nagpur
State/Province
Maharashtra
ZIP/Postal Code
440010
Country
India
Facility Name
Poona Medical Foundation. Ruby Hall Clinic
City
Pune
State/Province
Maharashtra
ZIP/Postal Code
411 001
Country
India
Facility Name
Datta Meghe Institute of Medical Sciences (DU), Acharya Vinoba Bhave Rural Hospital
City
Wardha
State/Province
Maharashtra
ZIP/Postal Code
442004
Country
India
Facility Name
Dayanand Medical College and Hospital
City
Ludhiana
State/Province
Punjab
ZIP/Postal Code
141001
Country
India
Facility Name
SR Kalla Memorial Gastro & General Hospital
City
Jaipur
State/Province
Rajasthan
ZIP/Postal Code
302001
Country
India
Facility Name
King George Medical University
City
Lucknow
State/Province
Uttar Pradesh
ZIP/Postal Code
226003
Country
India
Facility Name
Fortis Hospital
City
Noida
State/Province
Uttar Pradesh
ZIP/Postal Code
201301
Country
India
Facility Name
Gandhi Hospital
City
Telangana
ZIP/Postal Code
500003
Country
India
Facility Name
Beaumont Hospital, Dublin
City
Dublin
ZIP/Postal Code
D9
Country
Ireland
Facility Name
Shaare Zedek Medical Center
City
Bait Vagan
State/Province
Jerusalem
ZIP/Postal Code
91031
Country
Israel
Facility Name
Soroka Medical Center - Pediatric Outpatient Clinic
City
Beer-Sheva
ZIP/Postal Code
8410101
Country
Israel
Facility Name
Galilee Medical Center Department of Internal Medicine A
City
Nahariya
ZIP/Postal Code
2210001
Country
Israel
Facility Name
Kaplan Medical Center
City
Rehovot
ZIP/Postal Code
7610001
Country
Israel
Facility Name
Tel Aviv Sourasky Medical Center
City
Tel Aviv
ZIP/Postal Code
6423906
Country
Israel
Facility Name
Assaf Harofeh Medical Center
City
Zerifin
ZIP/Postal Code
70300
Country
Israel
Facility Name
Presidio di Rho
City
Rho
State/Province
Milano
ZIP/Postal Code
20017
Country
Italy
Facility Name
Istituto Clinico Humanitas
City
Rozzano
State/Province
Milano
ZIP/Postal Code
20089
Country
Italy
Facility Name
Istituti di Ricovero e Cura a Carattere Scientifico Policlinico San Donato Gastroenterologia
City
San Donato Milanese
State/Province
Milano
ZIP/Postal Code
20097
Country
Italy
Facility Name
Ospedale Sandro Pertini
City
Rome
State/Province
Roma
ZIP/Postal Code
00157
Country
Italy
Facility Name
Azienda Ospedaliera Universitaria Policlinico Tor Vergata
City
Torre
State/Province
Roma
ZIP/Postal Code
00133
Country
Italy
Facility Name
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)
City
Brescia
ZIP/Postal Code
25123
Country
Italy
Facility Name
Azienda ospedaliero-universitaria Mater Domini
City
Catanzaro
ZIP/Postal Code
88100
Country
Italy
Facility Name
Azienda Ospedaliero Universitaria San Martino
City
Genova
ZIP/Postal Code
16132
Country
Italy
Facility Name
Gastroenterology and Endoscopy Unit IRCCS Ca' Granda Ospedale Maggiore Policlinico Foundation
City
Milano
ZIP/Postal Code
20122
Country
Italy
Facility Name
Azienda Ospedaliera Universitaria Policlinico de Modena
City
Modena
ZIP/Postal Code
41124
Country
Italy
Facility Name
Azienda Ospedaliera Universitaria Pisana
City
Pisa
ZIP/Postal Code
56124
Country
Italy
Facility Name
Policlinico Gemelli - Università Cattolica del Sacro Cuore
City
Roma
ZIP/Postal Code
00168
Country
Italy
Facility Name
Ospedale Mauriziano Umberto I
City
Torino
ZIP/Postal Code
10128
Country
Italy
Facility Name
Azienda Ospedaliero-Universitaria Santa Maria della Misericordia Gastroenterologia
City
Udine
ZIP/Postal Code
33100
Country
Italy
Facility Name
Aichi Medical University Hospital
City
Nagakute-shi
State/Province
Aichi-ken
ZIP/Postal Code
480-1195
Country
Japan
Facility Name
Fujita Health University Hospital
City
Toyoake-shi
State/Province
Aichi-ken
ZIP/Postal Code
470-1192
Country
Japan
Facility Name
National Hospital Organization Hirosaki General Medical Center
City
Hirosaki
State/Province
Aomori
ZIP/Postal Code
036-8545
Country
Japan
Facility Name
Toho University Sakura Medical Center
City
Sakura
State/Province
Chiba
ZIP/Postal Code
285-0841
Country
Japan
Facility Name
Kitakyushu Municipal Medical Center
City
Kitakyusyu-shi
State/Province
Fukoka
ZIP/Postal Code
802-0077
Country
Japan
Facility Name
Hidaka Coloproctology Clinic
City
Kurume-shi
State/Province
Fukuoka-Ken
ZIP/Postal Code
839 0809
Country
Japan
Facility Name
Fukuoka University Chikushi Hospital
City
Chikushino
State/Province
Fukuoka
Country
Japan
Facility Name
Gunma University Hospital
City
Maebashi
State/Province
Gunma
ZIP/Postal Code
371-8511
Country
Japan
Facility Name
National Hospital Organization Takasaki General Medical Centar
City
Takasaki
State/Province
Gunma
ZIP/Postal Code
370-0829
Country
Japan
Facility Name
NHO Mito Medical Center
City
Ibaraki-machi
State/Province
HigaShiibaraki-Gun
ZIP/Postal Code
311 3193
Country
Japan
Facility Name
Asahikawa City Hospital
City
Asahikawa
State/Province
Hokkaido
ZIP/Postal Code
070-8610
Country
Japan
Facility Name
Tokushukai Sapporo Tokushukai Hospital
City
Sapporo-shi
State/Province
Hokkaido
ZIP/Postal Code
004 0041
Country
Japan
Facility Name
Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital
City
Sapporo-shi
State/Province
Hokkaido
ZIP/Postal Code
060 0033
Country
Japan
Facility Name
Sapporo Higashi Tokushukai Hospital
City
Sapporo
State/Province
Hokkaido
ZIP/Postal Code
065-0033
Country
Japan
Facility Name
Aoyama Clinic GI Endoscopy & IBD Center
City
Kobe-shi
State/Province
Hyogo-Ken
ZIP/Postal Code
650 0015
Country
Japan
Facility Name
Kagawa Prefectural Central Hospital
City
Takamatsu
State/Province
Kagawa
ZIP/Postal Code
760-8557
Country
Japan
Facility Name
Sankikai Yokohama Shin midori General Hospital
City
Yokohama-shi
State/Province
Kanagawa-Ken
ZIP/Postal Code
226 0025
Country
Japan
Facility Name
Ofuna Central Hospital
City
Kamakura
State/Province
Kanagawa
ZIP/Postal Code
247-0056
Country
Japan
Facility Name
Kawasaki Municipal Hospital
City
Kawasaki
State/Province
Kanagawa
ZIP/Postal Code
210-0013
Country
Japan
Facility Name
Yokohama City University Medical Center
City
Yokohama
State/Province
Kanagawa
ZIP/Postal Code
232-0024
Country
Japan
Facility Name
Showa University Northern Yokohama Hospital
City
Yokohama
State/Province
Kanagawa
ZIP/Postal Code
234-0032
Country
Japan
Facility Name
Kumamoto University Hospital
City
Kumamoto-shi
State/Province
Kumamoto
ZIP/Postal Code
860-0012
Country
Japan
Facility Name
Mie University Hospital
City
Tsu
State/Province
Mie
ZIP/Postal Code
514-8507
Country
Japan
Facility Name
Takagi Clinic - Sendai
City
Sendai-shi
State/Province
Miyagi-Ken
ZIP/Postal Code
981 3213
Country
Japan
Facility Name
Nagaoka Chuo General Hospital
City
Nagaoka-shi
State/Province
Niigata
ZIP/Postal Code
940-8653
Country
Japan
Facility Name
Ishida Clinic of IBD and Gastroenterology
City
Oita-shi
State/Province
Oita-Ken
ZIP/Postal Code
870 0823
Country
Japan
Facility Name
Sai Gastroenterologist Proctology
City
Fujiidera
State/Province
Osaka
ZIP/Postal Code
583-0027
Country
Japan
Facility Name
Infusion Clinic
City
Osaka-shi
State/Province
Osaka
ZIP/Postal Code
530 0011
Country
Japan
Facility Name
NHO Osaka National Hospital
City
Osaka-shi
State/Province
Osaka
ZIP/Postal Code
540 0006
Country
Japan
Facility Name
Saga-Ken Medical Center Koseikan
City
Saga-Shi
State/Province
Saga-Ken
ZIP/Postal Code
840-8571
Country
Japan
Facility Name
Kumagaya General Hospital
City
Kumagaya-shi
State/Province
Saitama-Ken
ZIP/Postal Code
360-8567
Country
Japan
Facility Name
Matsuda Hospital
City
Hamamatsu-shi
State/Province
Shizuoka-Ken
ZIP/Postal Code
4328061
Country
Japan
Facility Name
Jichi Medical University Hospital
City
Shimotsuke-shi
State/Province
Tochigi-Ken
ZIP/Postal Code
329-0498
Country
Japan
Facility Name
Mitsui Memorial Hospital
City
Chiyoda-ku
State/Province
Tokyo-To
ZIP/Postal Code
101-8643
Country
Japan
Facility Name
Center Hospital of the National Center for Global Health and Medicine
City
Shinjuku-ku
State/Province
Tokyo-To
ZIP/Postal Code
162 8655
Country
Japan
Facility Name
Juntendo University Hospital
City
Bunkyo-ku
State/Province
Tokyo
ZIP/Postal Code
113-8431
Country
Japan
Facility Name
Tokyo Medical and Dental University Hospital
City
Bunkyō
State/Province
Tokyo
ZIP/Postal Code
113-8519
Country
Japan
Facility Name
Showa University Koto Toyosu Hospital
City
Koto-ku
State/Province
Tokyo
ZIP/Postal Code
135 8577
Country
Japan
Facility Name
Kitasato University Kitasato Institute Hospital
City
Minato-Ku
State/Province
Tokyo
ZIP/Postal Code
108 8642
Country
Japan
Facility Name
Kyorin University Hospital
City
Mitaka
State/Province
Tokyo
ZIP/Postal Code
181-8611
Country
Japan
Facility Name
JHCO Tokyo Yamate Medical Center
City
Shinjuku-ku
State/Province
Tokyo
ZIP/Postal Code
169-0073
Country
Japan
Facility Name
Fukuoka University Hospital
City
Fukuoka
ZIP/Postal Code
814-0180
Country
Japan
Facility Name
Hiroshima University Hospital
City
Hiroshima
ZIP/Postal Code
734-8551
Country
Japan
Facility Name
Sameshima Hospital
City
Kagoshima
ZIP/Postal Code
892-0846
Country
Japan
Facility Name
National Hospital Organization Kyoto Medical Center
City
Kyoto
ZIP/Postal Code
612-8555
Country
Japan
Facility Name
Okayama University Hospital
City
Okayama
ZIP/Postal Code
700-8558
Country
Japan
Facility Name
Tokitokai Tokito Clinic
City
Saitama
ZIP/Postal Code
336-0963
Country
Japan
Facility Name
Toyama Prefectural Central Hospital
City
Toyama
ZIP/Postal Code
930-8550
Country
Japan
Facility Name
Severance Hospital, Yonsei University Health System
City
Wonju-si
State/Province
Gangwon-do
ZIP/Postal Code
26426
Country
Korea, Republic of
Facility Name
Kyung Hee University Hospital
City
Seoul
State/Province
Korea
ZIP/Postal Code
02447
Country
Korea, Republic of
Facility Name
Dong-A University Hospital
City
Busan
State/Province
Pusan-Kwangyǒkshi
ZIP/Postal Code
49201
Country
Korea, Republic of
Facility Name
Kangbuk Samsung Hospital
City
Seoul
State/Province
Seoul-teukbyeolsi [Seoul]
ZIP/Postal Code
03181
Country
Korea, Republic of
Facility Name
Asan Medical Center
City
Seoul
State/Province
Seoul-teukbyeolsi [Seoul]
ZIP/Postal Code
05505
Country
Korea, Republic of
Facility Name
Samsung Medical Center
City
Seoul
State/Province
Seoul-teukbyeolsi [Seoul]
ZIP/Postal Code
06351
Country
Korea, Republic of
Facility Name
The Catholic University of Korea, Daejeon St. Mary's Hospital
City
Daejeon
State/Province
Taejǒn-Kwangyǒkshi
ZIP/Postal Code
34943
Country
Korea, Republic of
Facility Name
Inje University Haeundae Paik Hospital
City
Busan
ZIP/Postal Code
48108
Country
Korea, Republic of
Facility Name
Yeungnam Univeristy Medical Center
City
Daegu
ZIP/Postal Code
42415
Country
Korea, Republic of
Facility Name
Pauls Stradins Clinical Univeristy Hospital
City
Riga
State/Province
Rīga
ZIP/Postal Code
LV-1002
Country
Latvia
Facility Name
Digestive Diseases Center "Gastro"
City
Riga
ZIP/Postal Code
1079
Country
Latvia
Facility Name
Riga Eastern Clinical University Hospital
City
Riga
ZIP/Postal Code
LV-1038
Country
Latvia
Facility Name
Respublikine Panevezio ligonine
City
Panevezys
State/Province
Panevėžio Apskritis
ZIP/Postal Code
LT-35144
Country
Lithuania
Facility Name
Hospital of Lithuanian University of Health Sciences Kaunas
City
Kaunas
ZIP/Postal Code
50009
Country
Lithuania
Facility Name
Republic Hospital of Klaipeda
City
Klaipeda
ZIP/Postal Code
92231
Country
Lithuania
Facility Name
Klaipeda Seamen's Hospital
City
Klaipeda
ZIP/Postal Code
92288
Country
Lithuania
Facility Name
Vilnius University Hospital Santariskiu Clinics
City
Vilnius
ZIP/Postal Code
LT-08661
Country
Lithuania
Facility Name
Universiti Sains Malaysia
City
Kubang Kerian
State/Province
Kelantan
ZIP/Postal Code
16150
Country
Malaysia
Facility Name
University Malaya Medical Centre
City
Lembah Pantai
State/Province
Kuala Lumpur
ZIP/Postal Code
59100
Country
Malaysia
Facility Name
Hospital Ampang
City
Ampang
State/Province
Selangor
ZIP/Postal Code
68000
Country
Malaysia
Facility Name
Centro de Investigación Clínica Acelerada
City
Mexico City
State/Province
Distrito Federal
ZIP/Postal Code
07020
Country
Mexico
Facility Name
Investigación Biomédica para el Desarrollo de Fármacos S.A. de C.V.
City
Zapopan
State/Province
Jalisco
ZIP/Postal Code
45030
Country
Mexico
Facility Name
Centro Para el Desarrollo de la Medicina y de Asistencia Med
City
Culiacan
State/Province
Sinaloa
ZIP/Postal Code
80230
Country
Mexico
Facility Name
Scientia Investigacion Clinica S.C.
City
Chihuahua
ZIP/Postal Code
31203
Country
Mexico
Facility Name
Sociedad de Metabolismo y Corazon
City
Veracruz
ZIP/Postal Code
91900
Country
Mexico
Facility Name
St Elisabeth Ziekenhuis
City
Tilburg
State/Province
Noord Brabant
ZIP/Postal Code
5022 GC
Country
Netherlands
Facility Name
Amsterdam UMC, locatie AMC
City
Amsterdam
State/Province
Noord-Holland
ZIP/Postal Code
1105 AZ
Country
Netherlands
Facility Name
Bernhoven Ziekenhuis
City
Uden
ZIP/Postal Code
5406 PT
Country
Netherlands
Facility Name
UMC Utrecht, Dept. of Internal Medicine, MDL
City
Utrecht
ZIP/Postal Code
3584 CX
Country
Netherlands
Facility Name
LexMedica
City
Wroclaw
State/Province
Dolnośląskie
ZIP/Postal Code
53-114
Country
Poland
Facility Name
Szpital Uniwersytecki Nr 2 w Bydgoszczy
City
Bydgoszcz
State/Province
Kujawsko-pomorskie
ZIP/Postal Code
85-168
Country
Poland
Facility Name
Centrum Medyczne Pratia Bydgoszcz
City
Bydgoszcz
State/Province
Kujawsko-pomorskie
ZIP/Postal Code
85-796
Country
Poland
Facility Name
ZOZ Gastromed
City
Lublin
State/Province
Lubelskie
ZIP/Postal Code
20-582
Country
Poland
Facility Name
Samodzielny Publiczny Szpital Kliniczny nr 4 w Lublinie
City
Lublin
State/Province
Lubelskie
ZIP/Postal Code
20-954
Country
Poland
Facility Name
NZOZ Vivamed
City
Warsaw
State/Province
Mazowieckie
ZIP/Postal Code
03-580
Country
Poland
Facility Name
Topolowa Medicenter
City
Krakow
State/Province
Małopolskie
ZIP/Postal Code
31-506
Country
Poland
Facility Name
Medicenter Nowy Targ
City
Nowy Targ
State/Province
Małopolskie
ZIP/Postal Code
34-400
Country
Poland
Facility Name
NZOZ Formed
City
Wadowice
State/Province
Małopolskie
ZIP/Postal Code
34-100
Country
Poland
Facility Name
Endoskopia Sp. z.o.o.
City
Sopot
State/Province
Pomorskie
ZIP/Postal Code
81-756
Country
Poland
Facility Name
SONOMED Centrum Medyczne
City
Szczecin
State/Province
Zachodniopomorskie
ZIP/Postal Code
71-685
Country
Poland
Facility Name
All-Medicus
City
Katowice
ZIP/Postal Code
40-660
Country
Poland
Facility Name
Wojewodzki Specjalistyczny Szpital w Olsztynie
City
Olsztyn
ZIP/Postal Code
10-561
Country
Poland
Facility Name
Twoja Przychodnia - Szczecinskie Centrum Medyczne
City
Szczecin
ZIP/Postal Code
71-434
Country
Poland
Facility Name
Gastromed Kopoń Zmudziński I Wspólnicy Spółka Jawna Specjalistyczne Centrum Gastrologii I Endoskopii
City
Torun
ZIP/Postal Code
87-100
Country
Poland
Facility Name
Warsaw IBD Point Profesor Kierkus
City
Warszawa
ZIP/Postal Code
00-728
Country
Poland
Facility Name
Centrum Zdrowia MDM
City
Warszawa
ZIP/Postal Code
00635
Country
Poland
Facility Name
Centrum Medyczne NeuroProtect
City
Warszawa
ZIP/Postal Code
01-697
Country
Poland
Facility Name
PlanetMed Sp.z o.o.
City
Wroclaw
ZIP/Postal Code
52-210
Country
Poland
Facility Name
ETG Zamość
City
Zamosc
ZIP/Postal Code
22-400
Country
Poland
Facility Name
Promedica Dental Clinic
City
Bedzin
State/Province
Śląskie
ZIP/Postal Code
42-500
Country
Poland
Facility Name
KO-Med Centrum Medyczne
City
Straszów
State/Province
Świętokrzyskie
ZIP/Postal Code
28-200
Country
Poland
Facility Name
CCBR Clinical Research
City
Bucharest
State/Province
București
ZIP/Postal Code
030463
Country
Romania
Facility Name
MedLife Grivita
City
Bucuresti
ZIP/Postal Code
010719
Country
Romania
Facility Name
Spitalul Clinic Colentina
City
Bucuresti
ZIP/Postal Code
020125
Country
Romania
Facility Name
Institutul Clinic Fundeni
City
Bucuresti
ZIP/Postal Code
022328
Country
Romania
Facility Name
Hifu Terramed Conformal SRL
City
Bucuresti
ZIP/Postal Code
031864
Country
Romania
Facility Name
Spital Pelican Oradea
City
Oradea
ZIP/Postal Code
410469
Country
Romania
Facility Name
Scientific Centre of Reconstructive and Restorative Surgery
City
Irkutsk
State/Province
Irkutskaya Oblast'
ZIP/Postal Code
664079
Country
Russian Federation
Facility Name
Karelia Republican Hospital V.A. Baranova
City
Petrozavodsk
State/Province
Kareliya, Respublika
ZIP/Postal Code
185019
Country
Russian Federation
Facility Name
Nizhny Novgorod Regional Hospital N.A. Semashko
City
Nizhny Novgorod
State/Province
Nizhegorodskaya Oblast'
ZIP/Postal Code
603126
Country
Russian Federation
Facility Name
Private Healthcare Institution Clinical Hospital Russian Railways - Medicine of Nizhniy Novgorod
City
Nizhny Novgorod
State/Province
Nizhegorodskaya Oblast'
ZIP/Postal Code
603140
Country
Russian Federation
Facility Name
Novosibirski Gastrocenter
City
Novosibirsk
State/Province
Novosibirskaya Oblast'
ZIP/Postal Code
630007
Country
Russian Federation
Facility Name
Rostov State Medical University
City
Rostov-on-Don
State/Province
Rostovskaya Oblast'
ZIP/Postal Code
344091
Country
Russian Federation
Facility Name
Scientific research center ECO-security
City
Saint Petersburg
State/Province
Sankt-Peterburg
ZIP/Postal Code
196143
Country
Russian Federation
Facility Name
Multidisciplinary Medical Clinic "Anthurium"
City
Barnaul
ZIP/Postal Code
656043
Country
Russian Federation
Facility Name
Medical and Sanitary Division of Severstal
City
Cherepovets
ZIP/Postal Code
162600
Country
Russian Federation
Facility Name
LLC MA New Hospital
City
Ekaterinburg
ZIP/Postal Code
620109
Country
Russian Federation
Facility Name
Alliance Biomedical URAL Group
City
Izhevsk
ZIP/Postal Code
426061
Country
Russian Federation
Facility Name
Clinical Trials Center of Medical Institute
City
Kaliningrad
ZIP/Postal Code
236035
Country
Russian Federation
Facility Name
State Autonomous Institution of Healthcare "Republican Clinical Hospital of the Ministry of Healthcare of Republic Tatarstan"
City
Kazan
ZIP/Postal Code
420064
Country
Russian Federation
Facility Name
SIH Kemerovo Regional Clinical Hosptial
City
Kemerovo
ZIP/Postal Code
650066
Country
Russian Federation
Facility Name
Medical rehabilitation center
City
Moscow
ZIP/Postal Code
125367
Country
Russian Federation
Facility Name
LLC "Medicine Center SibNovoMed"
City
Novosibirsk
ZIP/Postal Code
630005
Country
Russian Federation
Facility Name
Clinical Diagnostic Center Ultramed
City
Omsk
ZIP/Postal Code
644024
Country
Russian Federation
Facility Name
Saint Petersburg State Medical University n.a. Pavlov I.P.
City
Saint Petersburg
ZIP/Postal Code
197022
Country
Russian Federation
Facility Name
Pokrovskaya Municipal Hospital
City
Saint-Petersburg
ZIP/Postal Code
195067
Country
Russian Federation
Facility Name
Non-state Healthcare Institution "Roadway Clinical Hospital of OJSC Russian Railways"
City
Saint-Petersburg
ZIP/Postal Code
195271
Country
Russian Federation
Facility Name
SBIH City Clinical Hospital #31
City
Saint-Petersburg
ZIP/Postal Code
197110
Country
Russian Federation
Facility Name
Medical Institute REAVIZ
City
Samara
ZIP/Postal Code
443001
Country
Russian Federation
Facility Name
City Mariinskaya Hospital
City
St. Petersburg
ZIP/Postal Code
191104
Country
Russian Federation
Facility Name
Stavropol State Medical University
City
Stavropol
ZIP/Postal Code
355018
Country
Russian Federation
Facility Name
Yaroslavl Municipal HI Clinical Hospital #8
City
Yaroslavl
ZIP/Postal Code
150030
Country
Russian Federation
Facility Name
Clinical Hospital Center Zvezdara
City
Belgrade
State/Province
Beograd
ZIP/Postal Code
11000
Country
Serbia
Facility Name
University Medical Center "Bezanijska kosa"
City
Belgrade
State/Province
NAP
ZIP/Postal Code
11080
Country
Serbia
Facility Name
Regional Hospital Dr Radivoj Simonovic Sombor
City
Sombor
State/Province
Vojvodina
ZIP/Postal Code
25000
Country
Serbia
Facility Name
Sremska Mitrovica Health Centre
City
Sremska Mitrovica
State/Province
Vojvodina
ZIP/Postal Code
22000
Country
Serbia
Facility Name
General Hospital "Djordje Joanovic"
City
Zrenjanin
State/Province
Vojvodina
ZIP/Postal Code
23000
Country
Serbia
Facility Name
Clinical Center Kragujevac Gastroenterohepatology Clinic
City
Kragujevac
ZIP/Postal Code
34000
Country
Serbia
Facility Name
KM Management
City
Nitra
State/Province
Nitriansky Kraj
ZIP/Postal Code
949 01
Country
Slovakia
Facility Name
Gastro
City
Prešov
State/Province
Prešovský Kraj
ZIP/Postal Code
080 01
Country
Slovakia
Facility Name
Endomed, s.r.o.
City
Vranov N. Toplou
State/Province
Prešovský Kraj
ZIP/Postal Code
093 01
Country
Slovakia
Facility Name
Fakultna nemocnica s poliklinikou Roosevelta Banska Bystrica
City
Banska Bystrica
ZIP/Postal Code
975 17
Country
Slovakia
Facility Name
Univerzitna nemocnica Bratislava
City
Bratislava
ZIP/Postal Code
82007
Country
Slovakia
Facility Name
Hospital Universitario Virgen Del Rocio
City
Sevilla
State/Province
Andalucía
ZIP/Postal Code
41013
Country
Spain
Facility Name
Hospital Universitario Central de Asturias
City
Oviedo
State/Province
Asturias
ZIP/Postal Code
33011
Country
Spain
Facility Name
Hospital Universitari Son Espases
City
Palma de Mallorca
State/Province
Baleares Islands
ZIP/Postal Code
07120
Country
Spain
Facility Name
Hospital Universitario Marqués de Valdecilla
City
Santander
State/Province
Cantabria
ZIP/Postal Code
39008
Country
Spain
Facility Name
Hospital De Fuenlabrada
City
Fuenlabrada
State/Province
Madrid
ZIP/Postal Code
28942
Country
Spain
Facility Name
Hospital Gen. Juan Ramon Jimenez - Depto de Digestivo
City
Sagunto
State/Province
Valencia
ZIP/Postal Code
46520
Country
Spain
Facility Name
Instituto de Ciencias Médicas
City
Alicante
ZIP/Postal Code
3004
Country
Spain
Facility Name
Hospital Universitari de Girona
City
Girona
ZIP/Postal Code
17007
Country
Spain
Facility Name
Hospital Universitario Juan Ramon Jimenez
City
Huelva
ZIP/Postal Code
21005
Country
Spain
Facility Name
Complexo Hospitalario Universitario A Coruña, CHUAC
City
La Coruña
ZIP/Postal Code
15006
Country
Spain
Facility Name
Hospital De Gran Canaria Dr. Negrin
City
Las Palmas de Gran Canaria
ZIP/Postal Code
35010
Country
Spain
Facility Name
Hospital Universitario La Paz
City
Madrid
ZIP/Postal Code
28046
Country
Spain
Facility Name
Gastroenterologische Praxis Balsiger, Seibold & Partner
City
Bern
State/Province
Berne
ZIP/Postal Code
3012
Country
Switzerland
Facility Name
Inselspital Bern
City
Berne
ZIP/Postal Code
3010
Country
Switzerland
Facility Name
Kantonsspital St.Gallen
City
St.Gallen
ZIP/Postal Code
9007
Country
Switzerland
Facility Name
UniversitätsSpital Zürich
City
Zürich
ZIP/Postal Code
8091
Country
Switzerland
Facility Name
China Medical University Hospital
City
Taichung
ZIP/Postal Code
40447
Country
Taiwan
Facility Name
Health management center
City
Taipei
ZIP/Postal Code
10002
Country
Taiwan
Facility Name
Antalya Egitim ve Arastırma Hastanesi
City
Kocaeli
State/Province
Antalya
ZIP/Postal Code
7100
Country
Turkey
Facility Name
Acibadem Universitesi - Acibadem Kozyatagi Hastanesi
City
Kadıkoy
State/Province
Istanbul
ZIP/Postal Code
34734
Country
Turkey
Facility Name
Kocaeli University Medical Faculty Hospital
City
Izmit
State/Province
Kocaeli
ZIP/Postal Code
41380
Country
Turkey
Facility Name
Mersin University Medical Faculty
City
Yenişehir
State/Province
Mersin
ZIP/Postal Code
33110
Country
Turkey
Facility Name
Ege University Medicine of Faculty
City
Izmir
ZIP/Postal Code
35100
Country
Turkey
Facility Name
Ivano-Frankivsk Regional Clinical Hospital
City
Ivano-Frankivsk
State/Province
Ivano-Frankivsk Region
ZIP/Postal Code
76008
Country
Ukraine
Facility Name
City Clinical Hospital No. 2
City
Kharkiv
State/Province
Kharkivska Oblast
ZIP/Postal Code
61037
Country
Ukraine
Facility Name
Kherson City Clinical Hospital
City
Kherson
State/Province
Khersonska Oblast
ZIP/Postal Code
73000
Country
Ukraine
Facility Name
Medical Center of Limited Liability Company "Medical Center "Consilium Medical"
City
Kiev
State/Province
Kyiv
ZIP/Postal Code
4050
Country
Ukraine
Facility Name
Lviv Railway Clinical Hospital
City
Lviv
State/Province
Lvivska Oblast
ZIP/Postal Code
79000
Country
Ukraine
Facility Name
Lviv Regional Endocrinology Dispensary
City
Lviv
State/Province
Lvivska Oblast
ZIP/Postal Code
79000
Country
Ukraine
Facility Name
Municipal Non-Profit Enterprise "Lviv Clinical Emergency Care Hospital"
City
Lviv
State/Province
Lvivska Oblast
ZIP/Postal Code
79000
Country
Ukraine
Facility Name
Poltova Oblast Clinical Hospital IM.M.V.Sklifosovskoho
City
Poltava
State/Province
Poltavska Oblast
ZIP/Postal Code
36000
Country
Ukraine
Facility Name
Diaservis - Medical and Diagnostic Center
City
Zaporizhia
State/Province
Zaporizka Oblast
ZIP/Postal Code
69076
Country
Ukraine
Facility Name
Kharkiv City Student Hospital
City
Kharkiv
ZIP/Postal Code
61002
Country
Ukraine
Facility Name
GI L.T. Malaya TI Namsu
City
Kharkiv
ZIP/Postal Code
61039
Country
Ukraine
Facility Name
Treatment-Diagnostic Center of Private Enterprise of PPC Atsynus
City
Kropyvnytskyi
ZIP/Postal Code
25006
Country
Ukraine
Facility Name
Kyiv Municipal Clinical Hospital #1
City
Kyiv
ZIP/Postal Code
02091
Country
Ukraine
Facility Name
Communal institution of the Kyiv Regional Council "Kyiv Regional Clinical Oncology Dispensary"
City
Kyiv
ZIP/Postal Code
04078
Country
Ukraine
Facility Name
Communal institution of the Kyiv Regional Council "Kyiv Regional Clinical Oncology Dispensary"
City
Kyiv
ZIP/Postal Code
04107
Country
Ukraine
Facility Name
Communal Enterprise "Odesa Regional Clinical Hospital"
City
Odesa
ZIP/Postal Code
65000
Country
Ukraine
Facility Name
A. Novak Transcarpathian Regional Clinical Hospital
City
Uzhgorod
ZIP/Postal Code
88000
Country
Ukraine
Facility Name
Vinnytsia RCH of Veterans of War Dept of Therapy#1 Vinnytsia M.I.Pyrogov NMU
City
Vinnytsia
ZIP/Postal Code
21005
Country
Ukraine
Facility Name
MCIC MC LLC Health Clinic
City
Vinnytsia
ZIP/Postal Code
21009
Country
Ukraine
Facility Name
CCH #1 Vinnytsia M.I. Pyrogov NMU Ch of Propaedeutics of IM
City
Vinnytsia
ZIP/Postal Code
21029
Country
Ukraine
Facility Name
M.I. Pyrogov Regional Clinical Hospital
City
Vinnytsya
ZIP/Postal Code
21018
Country
Ukraine
Facility Name
Communal Institution of Kyiv Regional Council Kyiv Regional Hospital #2
City
Zaporizhzhia
ZIP/Postal Code
69104
Country
Ukraine
Facility Name
Queens Hospital
City
Romford
State/Province
Essex
ZIP/Postal Code
RM7 0AG
Country
United Kingdom
Facility Name
Fairfield General Hospital
City
Bury
State/Province
Great Britain
ZIP/Postal Code
BL9 7TD
Country
United Kingdom
Facility Name
St Thomas' Hospital
City
Great Maze Pond
State/Province
London
ZIP/Postal Code
SE1 9RT
Country
United Kingdom
Facility Name
Whipps Cross University Hospital
City
London
State/Province
Surrey
ZIP/Postal Code
E11 1NR
Country
United Kingdom
Facility Name
Morriston Hospital
City
Swansea
State/Province
Swansea [Abertawe Gb-ata]
ZIP/Postal Code
SA6 6SG
Country
United Kingdom
Facility Name
St James's University Hospital
City
Leeds
State/Province
Vinnytsia
ZIP/Postal Code
LS9 7TF
Country
United Kingdom
12. IPD Sharing Statement
Plan to Share IPD
Yes
IPD Sharing Plan Description
Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.
IPD Sharing Time Frame
Data are available 6 months after the primary publication and approval of the indication studied in the US and EU, whichever is later. Data will be indefinitely available for requesting.
IPD Sharing Access Criteria
A research proposal must be approved by an independent review panel and researchers must sign a data sharing agreement.
IPD Sharing URL
http://vivli.org/
Links:
URL
https://trials.lillytrialguide.com/en-US/trial/6R2qUhQWcgImGasYaaGmYq
Description
A Maintenance Study of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 2)
Learn more about this trial
A Maintenance Study of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis
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