CORset Versus OstéoSynthese in Adult Pyogenic Spondylodiscitis (COROSIVE)
Spondylodiscitis
About this trial
This is an interventional other trial for Spondylodiscitis focused on measuring Spondylodiscitis, spinal infection, back pain, quality of life, fusion, minimal invasive surgery, brace treatment
Eligibility Criteria
Inclusion criteria:
- adult patients presenting acute pyogenic spondylitis of the thoracolumbar spine
- back pain at a minimum of 4 out of 10 on VAS
- Diagnostic MRI and disc puncture + microbiological analysis required for antibiotic treatment and/or blood culture
- Vertebral body involvement (osteolysis) < 50% of VB height documented on CT
Exclusion criteria:
- postoperative pyogenic spondylitis or infection after spinal instrumentation spinal tuberculosis and mycosis
- contra-indications for surgery or general anaesthesia
- general septic conditions acute endocarditis documented by sonography
- patients presenting another major abcess or an epidural abscess
- Absence of vertebral body involvement (osteolysis) on CT or minor VB involvement less than 10% of VB height (surgery not indicated)
- Major destruction of vertebral body (>50%) on CT (surgery mandatory) Patients with concomitant bacterial endocarditis
Sites / Locations
- CHU de Bordeaux - Hôpital Pellegrin - Unité d'orthopédie-traumatologie rachis I
- CHU de CAEN
- Hôpital Beaujon - Service de Chirurgie Orthopédique et Traumatologie
- CHU François Mitterand - Bocage central - Service de Neurochirurgie
- CHU de GRENOBLE
- CHU Lyon - Hôpital Pierre Wertheimer - Service de Neurochirurgie C et chirurgie du rachis
- CHU Marseille - Hôpital Timone - Service de chirurgie orthopédique et traumatologique
- Hôpital Gui de Chauliac - Service de Neurochirurgie
- Hôpital Central - Service de Neurochirurgie
- CHU Hôtel Dieu - Service de Neurotraumatologie
- CHU Nice - Hôpital Pasteur 2 - Unité de Chirurgie Rachidienne
- Hôpital Pitié - Salpêtrière - Service de Chirurgie orthopédique
- Hôpital européen Georges-Pompidou - Service d'Orthopédie/Traumotologie
- CHU Reims - Hôpital Maison Blanche - Service de Neurochirurgie
- Hôpitaux Universitaires de Strasbourg - Service de chirurgie du rachis
Arms of the Study
Arm 1
Arm 2
Other
Other
Surgery
Brace
Patients with spondylodiscitis are operated by percutaneous instrumentation and receive an antibiotic treatment according to the bacterium evidenced in the initial diagnostic intervertebral disc puncture (6 weeks to 3 months according to CRP course)
Patients with spondylodiscitis are wearing a thoracolumbar brace for 3 months and receive an antibiotic treatment according to the bacterium evidenced in the initial diagnostic intervertebral disc puncture (6 weeks to 3 months according to CRP course)