COrticosteroids in acUte uRticAria in emerGency dEpartment (COURAGE)
Urticaria, Angiœdema
About this trial
This is an interventional treatment trial for Urticaria focused on measuring Acute urticaria
Eligibility Criteria
Inclusion Criteria:
- Age > 18 years
- Isolated acute urticaria (acute hives): spontaneous urticaria, inducible urticaria
- Acute urticaria with angioedema without laryngeal edema
- Obtain patient's consent
- Social security affiliation
Exclusion Criteria:
- Pregnancy or breastfeeding
- Acute hives with anaphylaxis
- Bradykinin angioedema
- Angioedema without urticaria (hives)
- Laryngeal edema with urticaria (hives)
- Corticosteroid administration in the previous 5 days visiting the emergency department
- Antihistamines greater than 1 tablet per day in the previous 5 days visiting the ED
- Other treatment for urticaria : omalizumab, montelukast, ciclosporine A
- Chronic urticaria before acute urticaria diagnosis
- Atopic dermatitis
- Eczema
- Bullous pemphigoid
- Acute exanthematous pustulosis
- Diabetes mellitus
- Gastrointestinal ulcer
- Refusal to participate
- Known allergy to the study drugs or formulation ingredients
- Known Renal failure defined by creatinine clearance < 10 mL/min or cardiac failure defined by ejection fraction < 40%.
- Corticoid use in 5 days prior to randomisation
- Contra-indication to corticotherapy:
- Any live vaccine
- Psychotic states still uncontrolled by treatment limiting the participant's compliance with the research
Sites / Locations
- Hospital Louis MOURIERRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Antihistamines + placebo of cortancyl
Association of antihistamines and cortancyl
- In emergency department : Levocetirizine 5 mg orally. Renewable once if persistence of hives at 30 minutes. Placebo of Cortancyl : 1mg/kg (the number of tablets the patient needs to take is based on his weight and is noted on annex 4), once orally - At home : Levocetirizine 5 mg twice daily for 7 days (D1 to D7). If persistence of hives, levocetirizine 10 mg twice daily for 7 more days (D8 to D14). Placebo of Cortancyl 20 mg x 2 tablets = 40mg once per day for 3 days orally
- In emergency department : Levocetirizine 5 mg orally Renewable once if persistence of hives at 30 minutes. Cortancyl: 1 mg/kg (the number of tablets the patient needs to take is based on his weight and is noted on annex 4), once orally. - At home : Levocetirizine 5 mg twice daily for 7 days (D1 to D7). If persistence of hives, levocetirizine 10 mg twice daily for 7 more days (D8 to D14). Cortancyl : 20 mg x 2 tablets = 40 mg per day for 3 days orally