Patient Perception and Clinical Efficacy of a Collagen Matrix for the Treatment of Peri-implantitis
Peri-Implantitis
About this trial
This is an interventional treatment trial for Peri-Implantitis
Eligibility Criteria
Inclusion Criteria:
- Informed consent after the detailed information on the study.
- Adults aged at least 18 years old.
- Candidates for receiving augmentation of the peri-implant keratinized mucosa.
- Presence of the implant diagnosed with peri-implantitis (radiographic bone loss > 2 mm, with a probing depth > 5 mm, bleeding and/or suppuration (Lang et al., 2011)).
- Absent or insufficient keratinized peri-implant mucosa (<2 mm).
Exclusion Criteria:
- General contraindications for the dental/surgical treatment;
- Inflammatory or autoimmune disease of the oral cavity;
- Implant with radiographic intraosseous defects more than 3 mm;
- Smokers > 10 cig/day;
- Allergy to collagen or analgesics/anti-inflammatory non-steroid drugs;
- History of cancer in various parts of the body which required radiotherapy or chemotherapy during the last 5 years;
- Radiotherapy of the head or neck in the last 5 years;
- Actual medication with immunosuppressors, bisphosphonates or high doses of corticosteroids;
- Pregnant or lactating women;
- Women in fertile age, who do not use effective methods of contraception;
- Participants of other studies of biomedical investigation during the last 24 weeks before initiation of the study.
Sites / Locations
- Faculty of Dentistry, Univesity Complutense, MadridRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Acellular collagen matrix
Autogenous free gingival graft
In a test group, partial thickness-flap will be elevation will be performed, in order to create the vascular recipient bed for the randomized graft. Implant surface will be treated with ultrasound device, glycine powder and implantoplasty in case of the exposure of the rough surface. Acellular collagen matrix will be adapted and suture to the vascular bed.
In a control group, partial thickness-flap will be elevation will be performed, in order to create the vascular recipient bed for the randomized graft. Implant surface will be treated with ultrasound device, glycine powder and implantoplasty in case of the exposure of the rough surface. Free gingival graft will be harvested from the zone of the posterior palate, and then adapted and sutured to the vascular bed.