Frozen Blastocyst Transfer Using Conventional Timing Versus Timing by Endometrial Receptivity Analysis (Synchrony)
Implantation Failure, Infertility, Female
About this trial
This is an interventional diagnostic trial for Implantation Failure focused on measuring Endometrial receptivity analysis, Window of implantation, Euploid, Infertility, Female, Implantation failure, Frozen embryo transfer FET, ERA, WOI, FET, Synchrony
Eligibility Criteria
Inclusion Criteria:
- Signed informed consent
- Female age between 30 and 40 years and deemed likely by her physician, based on ovarian reserve testing, to produce at least one euploid blastocyst via one IVF/intracytoplasmatic sperm injection (ICSI) cycle
- Having ≥ 1 euploid embryo available for embryo transfer
- Standard eligibility criteria to undergo IVF and FET at Shady Grove Fertility Center.
Exclusion Criteria:
- Known uterine factor impacting the endometrium
- Use of surgically aspirated sperm for fertilization
- Presence of any clinically relevant systemic disease that contraindicates assisted reproductive technology.
- Since the subject last had a live birth (if any), there have been more than two embryo transfers that have not resulted in ongoing pregnancy
- Body mass index >40 kg/m2 at screening
- Recurrent pregnancy loss, defined as two or more clinical pregnancy losses without live birth
- Planned testing of embryos for single gene disorder(s) or structural chromosome rearrangements
- Currently breast feeding, pregnant, or contraindication to pregnancy
Sites / Locations
- Shady Grove Fertility Reproductive Science Center
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
FET according to ERA
FET according to standard protocol
In preparation for frozen embryo transfer (FET), estradiol will be administered for approximately 10 to 14 days or until endometrial criteria are met. These endometrial criteria will be assessed with transvaginal ultrasound and serum estradiol levels. Women will then begin intramuscular progesterone injection and if assigned to the study arm, a single euploid embryo will be transferred at the time indicated by the ERA test results. Merely the timing of embryo transfer will distinguish the study from the control group.
In preparation for frozen embryo transfer (FET), estradiol will be administered for approximately 10 to 14 days or until endometrial criteria are met. These endometrial criteria will be assessed with transvaginal ultrasound and serum estradiol levels. Women will then begin intramuscular progesterone injection and if assigned to the control arm, a single euploid embryo will be transferred according to our standard FET protocol.