Treating Arteriovenous Malformation With Stereotactic Radiosurgery Using CT Angiography for Treatment Planning
Arteriovenous Malformations
About this trial
This is an interventional other trial for Arteriovenous Malformations
Eligibility Criteria
Inclusion Criteria:
- Documented AVM with draining vein(s).
- Adequate renal function (within 30 days) to undergo contrast CT and interventional cerebral arteriography on the same day, as determined by treating physicians.
- AVM must be physically separated from the optic pathway, brainstem or spinal cord.
- The maximum diameter of AVM nidus must be less than 3.5 cm and/or less than 12 cc.
- Age ≥ 10 years.
Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) at least three weeks prior and three weeks after the SRS procedure.
6.1 A female of child-bearing potential is any woman (regardless of sexual orientation, having undergone a tubal ligation, or remaining celibate by choice) who meets the following criteria:
- Has not undergone a hysterectomy or bilateral oophorectomy; or
- Has not been naturally postmenopausal for at least 12 consecutive months (i.e., has had menses at any time in the preceding 12 consecutive months).
6.2 Negative urine hCG test (within 30 days) for female of child-bearing potential.
- Ability to understand and the willingness to sign a written informed consent.
Exclusion Criteria:
- Patients without a documented AVM.
- Patients with a contraindication to CT or MRI such as contrast allergy, kidney failure or implanted metal devices or foreign bodies or severe claustrophobia.
- Use of Nephrotoxic drugs, such as gentamycin, high-dose nonsteroidal anti-inflammatory drugs, or certain chemotherapeutic drugs within 10 days of the procedure.
- Recent (within 10 days) or ongoing urinary tract infection (UTI).
- Psychiatric illness/social situations that would limit compliance with study requirements.
- Patients must not be pregnant at the time of SRS treatment.
Sites / Locations
- University of Texas Southwestern Medical Center
Arms of the Study
Arm 1
Experimental
Patient with AVM requiring radiotherapy
Patients on this protocol will still get treated based on target generated by interventional cerebral arteriography but also receive CT angiography.