The Effect of Structured Exercise on Chronic Venous Insufficiency (CVI)
Primary Purpose
Chronic Venous Insufficiency
Status
Unknown status
Phase
Not Applicable
Locations
Ireland
Study Type
Interventional
Intervention
Strength From Within
Sponsored by
About this trial
This is an interventional treatment trial for Chronic Venous Insufficiency focused on measuring CVI, Calf Muscle Pump Function, Structured Exercise, Varicose Veins
Eligibility Criteria
Inclusion Criteria:
- Adult patients with chronic venous insufficiency and a Comprehensive Classification System for Chronic Venous Disorder (CEAP) Score of 2,3,4.
Exclusion Criteria:
- Younger than 18 years
- Painful Ulceration
- Severe Cardiac Condition
- Cardiorespiratory Disease
- Failure of Physical Activity Readiness form
- American College of Sports Medicine (ACSM) Risk Classification: Class C or above
- CEAP classification of 5 or 6
- Severe mobility impairment
- Severe imbalance
- Women who are pregnant
- Women who are breastfeeding
- Those who lack capacity to consent
- Those for whom English is not the first language and have difficulty understanding written and/or spoken English
- Diagnosis of diabetes
- Diagnosis of peripheral arterial disease
- Diagnosis of peripheral neuropathy
Sites / Locations
- Galway ClinicRecruiting
Arms of the Study
Arm 1
Arm Type
Experimental
Arm Label
Structured Resistance Exercise
Arm Description
12 week at home structured resistance exercise programme ('Strength From Within') using resistance bands. Under the supervision of an experienced exercise specialist.
Outcomes
Primary Outcome Measures
Calf Muscle Pump Function
Duplex Ultrasound Scanning-to determine the nature and extent of venous reflux
Calf Muscle Strength
Isokinetic Testing- Biodex
Venous Clinical Severity Score
Questionnaire assessing severity of the patients' chronic venous insufficiency and to monitor any progression made
Secondary Outcome Measures
Ankle Joint Range of Motion
Goniometer
Overall physical strength
Muscle Strength Endurance Testing
Quality of life
SF-36 Short Form Health Survey
Full Information
NCT ID
NCT03562546
First Posted
June 4, 2018
Last Updated
June 17, 2018
Sponsor
Shannon Hernon
Collaborators
Galway Clinic
1. Study Identification
Unique Protocol Identification Number
NCT03562546
Brief Title
The Effect of Structured Exercise on Chronic Venous Insufficiency
Acronym
CVI
Official Title
The Effect of Structured Exercise on Chronic Venous Insufficiency: A Feasibility Trial
Study Type
Interventional
2. Study Status
Record Verification Date
June 2018
Overall Recruitment Status
Unknown status
Study Start Date
August 1, 2018 (Anticipated)
Primary Completion Date
November 30, 2018 (Anticipated)
Study Completion Date
February 28, 2019 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor-Investigator
Name of the Sponsor
Shannon Hernon
Collaborators
Galway Clinic
4. Oversight
Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No
5. Study Description
Brief Summary
Individuals with Chronic Venous Insufficiency (CVI) face a number of complications, such as, muscular dysfunction, limited ankle range of motion(ROM) and diminished calf muscle pump function. Exercise therapy has been shown to improve calf muscle pump function and symptoms and may provide additional therapeutic benefits. It has been reported that structured exercise has the ability to improve ankle joint range of motion, calf muscle strength and calf muscle pump function.
Participants will receive the 12-week structured resistance exercise programme, 'Strength from Within', a warm up and cool down, walking programme and range of motion exercises. Participants will complete the Short Form quality of life (SF-36) Health Survey and the venous clinical severity score questionnaire.
Baseline testing will be conducted. The following measures will be employed in the study through a baseline testing and repeated at the end of the study period (week 12): Functional ambulatory measurements, physical activity measurements (muscle endurance), isokinetic testing (strength), duplex ultrasound scanning.
A combination of upper and lower body structured exercise as well as, ankle join range of motion and a walking regimen has the potential to have a significant impact on an individual's calf muscle pump function and avoid these potentially harmful side effects of lower body exercise programmes
Detailed Description
There will be a total of sixty participants recruited for the study, with an anticipation of 40 to complete the study. Participants will complete the Physical Activity Readiness Questionnaire (PAR-Q) to ensure that they are able to participate in the structured exercise programme. If the participants' answers "yes" to any question on the Physical Activity Readiness Questionnaire (PAR-Q), he/she is ineligible to participate. Participants will also read a participant information leaflet and sign an informed consent before participating in the study. Baseline demographic will be collected at the start of the study. Participants will complete the SF-36 Health Survey at session one and session 2 (week 12). Baseline testing will be conducted. The following measures will be employed in the study through a baseline testing and repeated at the end of the study period (week 12): Functional ambulatory measurements, physical activity measurements, isokinetic testing, duplex ultrasound screening.
Upon completing baseline testing participants will have the warm-up, cool-down, stretches, all exercise demonstrated and explained to them. Participants will go through each exercise with the principal investigator to ensure understanding. The principal investigator will then describe each section of the "Strength From Within" Booklet. At the end of the first session the participants will be administered their at home structured exercise booklet, recording booklet, resistance band, warm-up and cool-down information sheet and their ankle range of motion information sheet.
The baseline meeting and the week 12 meeting will take roughly 90 minutes to complete all baseline measurements, questionnaires, isokinetic testing and demonstrations. Isokinetic testing will take a total of 32 minutes with resting periods included in the time, baseline measurements including the muscle strength and functional ambulatory measurements will take a duration of 10.5 minutes, demonstration of the home structured exercise programme will take up to 20 minutes, both questionnaires will take 5-minutes total and time left for any other questions or concerns. Extra time will be given at any point during both meetings if needed by the participant.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Chronic Venous Insufficiency
Keywords
CVI, Calf Muscle Pump Function, Structured Exercise, Varicose Veins
7. Study Design
Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Single Group Assignment
Masking
None (Open Label)
Allocation
Non-Randomized
Enrollment
60 (Anticipated)
8. Arms, Groups, and Interventions
Arm Title
Structured Resistance Exercise
Arm Type
Experimental
Arm Description
12 week at home structured resistance exercise programme ('Strength From Within') using resistance bands. Under the supervision of an experienced exercise specialist.
Intervention Type
Other
Intervention Name(s)
Strength From Within
Intervention Description
A 12 week at home structured resistance exercise programme using resistance bands. Participants will also receive a walking programme, a warm up and cool down, and ankle range of motion exercises.
Primary Outcome Measure Information:
Title
Calf Muscle Pump Function
Description
Duplex Ultrasound Scanning-to determine the nature and extent of venous reflux
Time Frame
12 Weeks
Title
Calf Muscle Strength
Description
Isokinetic Testing- Biodex
Time Frame
12 Weeks
Title
Venous Clinical Severity Score
Description
Questionnaire assessing severity of the patients' chronic venous insufficiency and to monitor any progression made
Time Frame
12 Weeks
Secondary Outcome Measure Information:
Title
Ankle Joint Range of Motion
Description
Goniometer
Time Frame
12 Weeks
Title
Overall physical strength
Description
Muscle Strength Endurance Testing
Time Frame
12 Weeks
Title
Quality of life
Description
SF-36 Short Form Health Survey
Time Frame
12 Weeks
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
99 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Adult patients with chronic venous insufficiency and a Comprehensive Classification System for Chronic Venous Disorder (CEAP) Score of 2,3,4.
Exclusion Criteria:
Younger than 18 years
Painful Ulceration
Severe Cardiac Condition
Cardiorespiratory Disease
Failure of Physical Activity Readiness form
American College of Sports Medicine (ACSM) Risk Classification: Class C or above
CEAP classification of 5 or 6
Severe mobility impairment
Severe imbalance
Women who are pregnant
Women who are breastfeeding
Those who lack capacity to consent
Those for whom English is not the first language and have difficulty understanding written and/or spoken English
Diagnosis of diabetes
Diagnosis of peripheral arterial disease
Diagnosis of peripheral neuropathy
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Shannon M Hernon, PhDStudent
Phone
+353867761346
Email
shernon10@gmail.com
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Micheál Newell, PhD
Organizational Affiliation
National University of Ireland, Galway, Ireland
Official's Role
Principal Investigator
Facility Information:
Facility Name
Galway Clinic
City
Galway
Country
Ireland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Shannon M Hernon, PhD Student
Phone
0867761346
Email
shernon10@gmail.com
First Name & Middle Initial & Last Name & Degree
Micheál Newell, PhD
12. IPD Sharing Statement
Plan to Share IPD
Undecided
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The Effect of Structured Exercise on Chronic Venous Insufficiency
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