The Diet Gout Trial (DIGO)
Gout, Hyperuricemia
About this trial
This is an interventional treatment trial for Gout focused on measuring Diet, Nutrition, DASH, Gout, Hyperuricemia, Potassium, Uric acid, Trial, Blood pressure, Glucose, Lipid, Cholesterol, Weight, Arthritis, BMI, Body mass index, Fruit, Vegetable, Low fat dairy, Lean meat, Fiber
Eligibility Criteria
Inclusion Criteria:
Age > 18-100 years
Self-reported gout diagnosis
Serum Uric Acid > 7 mg/dL
Exclusion Criteria:
Recent or planned changes to urate lowering therapies (e.g. allopurinol, febuxostat, probenecid)
Recent or planned changes to hypertension, lipid, or diabetes medications
Patients with hyperkalemia (>5 mmol/L)
Chronic kidney disease (GFR < 30 cc/min), kidney transplant, dialysis
Gastro-intestinal conditions (e.g. history of gastric bypass surgery, active inflammatory bowel disease, malabsorption, or major GI resection)
Active cancer treatment (e.g. radiation or chemotherapy)
Diagnosis of any of the following in the past 6 months: heart attack, heart failure, angina, coronary bypass or angioplasty, or Chronic Obstructive Pulmonary Disease (COPD)
Alcohol use over 14 drinks per week
Inability to give informed consent
Active use of warfarin, insulin, or chronic steroids (like prednisone)
Terminal or mental illness
Sites / Locations
- Johns Hopkins ProHealth Research Clinic
- Massachusetts General Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Dietitian-Directed Diet
Self-Directed Diet
Participants will be provided $105/week ($15/day) to purchase foods in servings that correspond to the DASH diet and thus include fruits, vegetables, lean meat, low fat dairy, and high fiber foods. Participants will also be asked to restrict red meat, sweets, and sugary beverages during this intervention period. A dietitian will help participants order foods from a digital supermarket. Foods will be delivered to the Johns Hopkins ProHealth Research Clinic for weekly pick-up. This study period will last 4 weeks.
Participants will be asked to consume their typical diet for 4 weeks. There will be no subsidy during this period.