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Bethanechol Prior to Pancreatic Surgery

Primary Purpose

Pancreas Cancer

Status

Recruiting

Phase

Early Phase 1

Locations

United States

Study Type

Interventional

Intervention

Bethanechol

About this trial

This is an interventional other trial for Pancreas Cancer focused on measuring Pancreas, pancreatic adenocarcinoma, adenocarcinoma, bethanechol, parasympathetic

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

Be willing and able to provide written informed consent for the trial.
Age ≥18 years of age on the day of signing informed consent.
Have histologically or cytologically confirmed the diagnosis of resectable pancreatic ductal adenocarcinoma or be willing to undergo a biopsy with confirmed pathology prior to starting therapy.
Have a predicted life expectancy of greater than 3 months.
Have a performance status of 0 or 1 using the Eastern Cooperative Oncology Group (ECOG) Performance Status Scale within 3 days of the first dose of study drug.
Have a negative urine or serum pregnancy test within 7 days prior to receiving the first dose of study medication (Cycle 1, Day 1) (female subjects of childbearing potential). If the urine test is positive or cannot be confirmed as negative, a serum pregnancy test will be required

Exclusion Criteria:

Has received prior chemotherapy or radiotherapy for a current episode of pancreatic adenocarcinoma.
Is currently using an acetylcholinesterase inhibitor or a beta-blocker.
Has active peptic ulcer disease as defined by documented peptic ulcer and symptoms uncontrolled with oral medication.
Has a known hypersensitivity or allergy to bethanechol.
Has uncontrolled hyperthyroidism, defined as clinical hyperthyroidism uncontrolled by oral medication.
Has bradycardia with resting heart rate < 50 beats per minute.
Has chronic hypotension with resting systolic blood pressure < 90 mmHg.
Has symptomatic coronary artery disease, such as angina or symptoms of claudication
Has vasomotor instability.
Has seizure disorder or required anti-seizure medication for seizure prevention within 5 years prior to study entry.
Has a history of Parkinson's disease.
Has bronchial asthma.
Has a history of recent urinary bladder surgery within 12 months of study entry.
Has a history of gastrointestinal resection and anastomosis within 12 months of study entry.
Has a history of current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial, interfere with the subject's participation for the full duration of the trial, or is not in the best interest of the subject to participate, in the opinion of the treating investigator.
Has a known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial.
Is pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the trial, starting with the screening visit through 120 days after the last dose of trial treatment.

Sites / Locations

Columbia University Medical CenterRecruiting

Arms of the Study

Arm 1

Arm Type

Experimental

Arm Label

Bethanechol

Arm Description

Patients with pancreatic adenocarcinoma will receive bethanechol prior to pancreatic surgery

Outcomes

Primary Outcome Measures

Change in cell proliferation by Ki-67 expression in tumor cells

Individual tumor tissues will be evaluated, comparing pre-treatment and post-treatment samples. Percentage of change in proliferation/staining and standard deviation will be analyzed and calculated.

Secondary Outcome Measures

Number of Adverse Events

Subjects will be contacted every week (+/- 3 days) after the start of treatment to approximately 28 days after surgery.

Full Information

NCT ID

NCT03572283

First Posted

May 8, 2018

Last Updated

November 29, 2022

Sponsor

Columbia University

1. Study Identification

Unique Protocol Identification Number

NCT03572283

Brief Title

Bethanechol Prior to Pancreatic Surgery

Official Title

Phase 1 Window of Opportunity Study of Parasympathetic Stimulation With Bethanechol in Localized Pancreatic Adenocarcinoma Prior to Surgery

Study Type

Interventional

2. Study Status

Record Verification Date

November 2022

Overall Recruitment Status

Recruiting

Study Start Date

April 8, 2018 (Actual)

Primary Completion Date

January 2023 (Anticipated)

Study Completion Date

January 2024 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Principal Investigator

Name of the Sponsor

Columbia University

4. Oversight

Studies a U.S. FDA-regulated Drug Product

Yes

Studies a U.S. FDA-regulated Device Product

Product Manufactured in and Exported from the U.S.

Data Monitoring Committee

Yes

5. Study Description

Brief Summary

The primary objective of this study is to assess the impact of bethanechol therapy on tumor activity by looking at biomarkers of proliferation, inflammation, and stem cell markers in post-treatment specimens compared to pre-treatment specimens and compared to other patients who were not treated with bethanechol prior to surgery. The investigators hypothesize that treatment with bethanechol will alter nerve conduction within tumors by stimulating the parasympathetic nervous system and reduce tumor proliferation, reduce macrophage activation, reduce tumor necrosis factor (TNF) alpha, and decrease human cluster of differentiation 44 (CD44) protein cancer stem cells. The safety objective is to assess the safety and tolerability of short course bethanechol prior to surgery and the impact of this treatment on immediate surgical outcomes. The investigators will assess all treatment-related toxicities with an emphasis on GI side effects and evaluate the impact of therapy on surgical delays or immediate post-op complications. All subjects will be contacted 1 week after beginning therapy to assess toxicity including GI specific toxicity and followed for safety for 30 days following completion of study medication. The investigators hypothesize that treatment for a minimum of 1 week will be tolerable in this selected patient population and will not interfere with progression to surgery or lead to increased surgical complications.

Detailed Description

Pancreatic ductal adenocarcinoma (PDA) is one of the most difficult cancers and, unlike other common cancers, annual deaths from PDA are rising. During the year 2017, it was estimated that 53,670 people would be diagnosed with PDA and approximately 43,090 people would die in the U.S. Despite recent advances, cytotoxic chemotherapy for PDA has been disappointing with response rates of 20-30% for the most active regimens and little activity for targeted therapies. Even among the small subset of patients who are suitable for surgical resection at the time of diagnosis, complete resection is followed by recurrence in >90% of patients without further systemic therapy, with a median time to recurrence of 6.9 months. Thus all PDA patients require systemic chemotherapy and more effective regimens are urgently needed. The purpose of this study is to determine whether the drug, bethanechol, could potentially be used in combination with surgery to decrease the chance of cancer coming back after it is removed. Bethanechol is a medication that is approved by the FDA and regulates the parasympathetic nervous system. It is used to treat dry mouth and for patients who have difficulty urinating. It has been used to manage the side effects of chemotherapy drugs. The investigators planned this study in pancreatic cancer because animal models have shown that treatment with bethanechol can inhibit cancer growth and spread. People with pancreatic cancer localized to a small area usually undergo surgery to remove the tumor. The study is designed to investigate that the medication is easy to tolerate and that it shows signs of slowing cancer cell growth. .

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Pancreas Cancer

Keywords

Pancreas, pancreatic adenocarcinoma, adenocarcinoma, bethanechol, parasympathetic

7. Study Design

Primary Purpose

Other

Study Phase

Early Phase 1

Interventional Study Model

Single Group Assignment

Model Description

Phase 0 study to assess the impact of bethanechol on pancreatic cancer biomarkers

Masking

None (Open Label)

Allocation

N/A

Enrollment

18 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title

Bethanechol

Arm Type

Experimental

Arm Description

Patients with pancreatic adenocarcinoma will receive bethanechol prior to pancreatic surgery

Intervention Type

Drug

Intervention Name(s)

Bethanechol

Other Intervention Name(s)

Bethanechol chloride tablet

Intervention Description

Supplied as 50mg oral tablets. Take 2 tablets (total 100mg) twice daily from day 1 for a minimum of 1 week and a maximum of 4 weeks (or 2 days prior to scheduled surgery). Medication should be taken 1 hour before meals in the morning and the evening. Although bethanechol is FDA approved, in this study its use is experimental.

Primary Outcome Measure Information:

Title

Change in cell proliferation by Ki-67 expression in tumor cells

Description

Individual tumor tissues will be evaluated, comparing pre-treatment and post-treatment samples. Percentage of change in proliferation/staining and standard deviation will be analyzed and calculated.

Time Frame

Baseline, 28 days after surgery

Secondary Outcome Measure Information:

Title

Number of Adverse Events

Description

Subjects will be contacted every week (+/- 3 days) after the start of treatment to approximately 28 days after surgery.

Time Frame

Baseline, 28 days after surgery

10. Eligibility

Sex

All

Minimum Age & Unit of Time

18 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: Be willing and able to provide written informed consent for the trial. Age ≥18 years of age on the day of signing informed consent. Have histologically or cytologically confirmed the diagnosis of resectable pancreatic ductal adenocarcinoma or be willing to undergo a biopsy with confirmed pathology prior to starting therapy. Have a predicted life expectancy of greater than 3 months. Have a performance status of 0 or 1 using the Eastern Cooperative Oncology Group (ECOG) Performance Status Scale within 3 days of the first dose of study drug. Have a negative urine or serum pregnancy test within 7 days prior to receiving the first dose of study medication (Cycle 1, Day 1) (female subjects of childbearing potential). If the urine test is positive or cannot be confirmed as negative, a serum pregnancy test will be required Exclusion Criteria: Has received prior chemotherapy or radiotherapy for a current episode of pancreatic adenocarcinoma. Is currently using an acetylcholinesterase inhibitor or a beta-blocker. Has active peptic ulcer disease as defined by documented peptic ulcer and symptoms uncontrolled with oral medication. Has a known hypersensitivity or allergy to bethanechol. Has uncontrolled hyperthyroidism, defined as clinical hyperthyroidism uncontrolled by oral medication. Has bradycardia with resting heart rate < 50 beats per minute. Has chronic hypotension with resting systolic blood pressure < 90 mmHg. Has symptomatic coronary artery disease, such as angina or symptoms of claudication Has vasomotor instability. Has seizure disorder or required anti-seizure medication for seizure prevention within 5 years prior to study entry. Has a history of Parkinson's disease. Has bronchial asthma. Has a history of recent urinary bladder surgery within 12 months of study entry. Has a history of gastrointestinal resection and anastomosis within 12 months of study entry. Has a history of current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial, interfere with the subject's participation for the full duration of the trial, or is not in the best interest of the subject to participate, in the opinion of the treating investigator. Has a known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial. Is pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the trial, starting with the screening visit through 120 days after the last dose of trial treatment.

Central Contact Person:

First Name & Middle Initial & Last Name or Official Title & Degree

Research Nurse Navigator

Phone

(212) 342-5162

cancerclinicaltrials@cumc.columbia.edu

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Susan E Bates, MD

Organizational Affiliation

Columbia University

Official's Role

Principal Investigator

Facility Information:

Facility Name

Columbia University Medical Center

City

New York

State/Province

New York

ZIP/Postal Code

10032

Country

United States

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Susan Bates, MD

seb2227@cumc.columbia.edu

First Name & Middle Initial & Last Name & Degree

Susan Bates, MD

12. IPD Sharing Statement

Plan to Share IPD

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