Management of Pain in Oral Lichen Planus
Oral Lichen Planus
About this trial
This is an interventional supportive care trial for Oral Lichen Planus
Eligibility Criteria
Inclusion Criteria:
- histological diagnosis of OLP on the basis of WHO criteria (Meji and van der Waal 2003).
- presence of painful and atrophic-erosive oral lesions, unresponsive to topical corticosteroid therapy
- ability to complete the present clinical trial.
Exclusion Criteria:
- Presence of histological signs of dysplasia
- use of lichenoid reaction inducing drugs
- Therapy for OLP in the 2 months prior to the study;
- Patients suffering from any disease that may present with features similar to OLP (graft versus host disease or lupus erythematosus)
- Pregnant or lactating females
- Patients with uncontrolled diabetes or hypertension, positive HCV Ab or HBs Ag.
- Smokers
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
comparison group (active control)
experimental group
0.1 % topical triamcinolone acetonide preparation (Kenacourt-A Orabase Pomad, DEVA HOLDINGS A.S., Istanbul, Turkey) was used where the patients' were instructed to apply the gel 4 times daily, with no food or fluid taken one hour after application. Patients used the medication for 4 weeks , and if extension of treatment was required after that period , patients were instructed to apply miconazole oral gel (JANSSEN-CILAG Pty Ltd 1-5 Khartoum Road North Ryde NSW 2113 Australia) four times a day for one week to protect from superimposed fungal infections.15
OLP lesions were irradiated with a 970-nm diode laser (SIRO Laser Advance class III b, SIRONA, Germany) with a 2 W irradiation power in a continuous non-contact mode. The laser beam was delivered using a fiber-optic tip with a 320 µm diameter with defocused mode directed at the lesions plus 0.5 cm peri- lesional tissues with a slight overlapping in order to evenly distribute energy covering all the lesional and peri-lesional tissues until blanching of the area was observed.14 Diode laser was calibrated to an output power of 3W, frequency of 30 Hz, energy of 180 joule and time interval of 8 minutes divided into 4 sessions , two min each with one minute rest in between to allow for tissue relaxation. Irradiation was done twice weekly for two months until the resolution of signs for a maximum of ten sessions.11 After each session, patients were advised to have a cold diet and use chlorhexidine oral gel postoperatively twice a day to the lesion for one week.