Brain Targets in Patients With Bladder Emptying Difficulties
Neurogenic Bladder, Multiple Sclerosis, Voiding Dysfunction
About this trial
This is an interventional treatment trial for Neurogenic Bladder focused on measuring Neurogenic bladder, Functional Neuroimaging, Transcranial Rotating Permanent Magnet Stimulator (TRPMS)
Eligibility Criteria
Inclusion Criteria:
Inclusion Criteria for subjects with neurogenic bladder:
- Patients with clinical diagnosis of neurogenic bladder
- History of any neurologic illness or injury (including but not limited to spinal cord injury, Multiple Sclerosis, Stroke, spina bifida, Parkinson's, major spine surgery)
- 18 years or older
Specifics for MS patients:
Adult female patients with clinically stable MS [Expanded Disability Status Score (EDSS) ≤6.5], with bladder symptoms ≥3 months, will be screened. Patients will be considered to have VD if they have an increased Postvoid Residual (≥ 20% Maximum Cystometric Capacity). Patients who perform self-catheterization will be included in the VD category as well.
Exclusion Criteria:
Exclusion Criteria for subjects with neurogenic bladder:
- Men (for aims 1 and 2 only), anatomical bladder outlet obstruction (anti-incontinence procedures, urethral strictures, or advanced pelvic organ prolapse). Severe debilitating MS, history of seizures, pregnancy or planning to become pregnant, contraindications to MRI, history of augmentation cystoplasty. Patients with active UTI can be treated and subsequently screened for the trial.
- Positive urine pregnancy test at enrollment (There are no known risks to a subject's fetus. There is no known teratogenic risk associated with urodynamics or fMRI) - Cognitively impaired patients
Sites / Locations
- Houston Methodist Hospital
Arms of the Study
Arm 1
Experimental
Subjects with Multiple Sclerosis and Voiding Dysfunction
Subjects with Multiple Sclerosis (MS) and voiding dysfunction (VD). In this group 'Transcranial Rotating Permanent Magnet Stimulator (TRPMS)' device will be used.