CONsciousness Transcranial Electric STimulation (CONTEST_3)
Disorder of Consciousness
About this trial
This is an interventional treatment trial for Disorder of Consciousness focused on measuring State of consciousness, tACS, tDCS, Global neuronal workspace, Brain injury
Eligibility Criteria
Inclusion Criteria:
- Age between 18 and 80 years
- Non communicative patients with disorder of consciousness diagnosed by CRS-R (VS, MCS, exitMCS)
- Patients with stable clinical examination (even in intensive care)
- Brain injury confirmed by cerebral imaging (MRI or TDM)
- French social security affiliation
- Signed and informed consent by the patient or by a legal representant
Exclusion Criteria:
- Status epilepticus or uncontrolled epilepsy
- Severely neurodegenerative illnesses (Alzheimer disease, Lewy Body Dementia)
- Electrical stimulation contraindication (metallic intra-cranial implants, pacemaker or implantable cardioverter-defibrillator, cranial prosthesis)
- Pregnant, parturient or breastfeeding women- Patients underage
Sites / Locations
- Institut du Cerveau et de la Moelle - CR-ICM U 975 / UMRS INSERM 1127Recruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Sham Comparator
Experimental
Sham Comparator
In-phase 6 Hz prefronto-parietal tACS
Sham prefronto-parietal tACS
2 mA left prefrontal tDCS
Sham left prefrontal tDCS
6 Hz stimulation (1000 μA) with transcranial Alternative Current Stimulation (tACS) will be applied simultaneously over the left prefrontal dorso-lateral cortex (F3 of the 10-20 international scalp EEG system) and the left parietal cortex (P3 of the 10-20 international scalp EEG system, with a return electrode in Cz) for 20 minutes. The phase difference between the two stimulation sites will be 0°.
The same stimulation as in in-phase transcranial Alternative Current Stimulation tACS (6 Hz F3 and P3 stimulation with 0° phase difference) will start with a current intensity of 1000 μA lasting for 30 seconds. Afterwards, the intensity will progressively decrease over 20 seconds until cessation. The whole session duration is 20 minutes.
2000 μA anodal transcranial Direct Current Stimulation (tDCS) will be applied over the left prefrontal dorso-lateral cortex (F3 of the 10-20 international scalp EEG system with a right supraorbital return electrode (Fp2 of the 10-20 international scalp EEG system) during 20 minutes.
The same stimulation as active transcranial Direct Current Stimulation (tDCS) (anodal F3 and return in Fp2) will start at 2 mA intensity for 30 seconds. Afterwards, the intensity will progressively decrease over 20 seconds until cessation. The whole session duration is 20 minutes.