Genetic Counselling in the Prevention of Mental Health Consequences of Cannabis Use (IMAGINE)
Mental Illness, Schizophrenia, Bipolar Disorder
About this trial
This is an interventional prevention trial for Mental Illness focused on measuring Severe mental illness, Developmental psychopathology, Trial-within-cohort, Genetic counselling, Cannabis use, Prevention
Eligibility Criteria
Inclusion Criteria:
- Enrolment in the Families Overcoming Risks and Building Opportunities for Well-being (FORBOW) study.
- Age between 12 and 21 years.
- Knowledge of English sufficient to benefit from the intervention.
- Capacity to provide informed consent at most recent FORBOW assessment.
- Provision of consent to be contacted about future studies at most recent FORBOW assessment.
Exclusion Criteria:
- A diagnosis of severe mental illness (psychotic disorder, bipolar disorder, severe/recurrent depression) at baseline
- Autism or intellectual disability of a degree that interferes with assessment (IQ < 70)
Sites / Locations
- Nova Scotia Health AuthorityRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Genetic counselling
Control group
Eligible participants who are randomized will be contacted and offered an invitation to attend the intervention. Genetic counselling will be provided to participants who accept the intervention as a single 1-2 hour session by a board-certified genetic counsellor. During the genetic counselling session, participants will have the option to receive their genotype at rs2494732. Participants will be counselled regarding their individualized risk of developing and of NOT developing SMI based on family history, whether or not they choose to use cannabis, and genotype (if they accept the genetic test results). Approximately 1 month after the intervention, participants will receive a follow-up interview.
Eligible participants who are not randomized to be offered the intervention will continue with their annual assessments as part of the parent study. These participants will receive the current standard of care (no intervention), and will not be offered or informed of the intervention.