Diesel Exhaust Induces Glucocorticoid Resistance (DIGR)
Exposure to Pollution, Glucocorticoid Resistance
About this trial
This is an interventional prevention trial for Exposure to Pollution focused on measuring Diesel Exhaust, Air Pollution, Inhaled Corticosteroids, Gene Expression, Asthma, Controlled Human Exposure Study
Eligibility Criteria
Inclusion Criteria:
- Aged 19-49
- Have physician-diagnosed asthma confirmed by the study physician examination, spirometry, methacholine challenge provocative concentration causing a 20% fall (PC20) of <16 mg/mL, and questionnaires during a screening visit
Exclusion Criteria:
- Smoking of any kind (0.5 pack-years ever, or any current) or use of vape/vaporizing devices
- Regular anti-histamine, NSAID, corticosteroid or other controller medication use
- Pregnancy or breastfeeding
- Methacholine PC20 >16
- Relevant cardiac condition or arrhythmia
- Body mass index of >35
- Currently participating in another study that may interfere with this study
- Use of either inhaled or oral corticosteroids in preceding 6 months
- Substantial comorbidities on study physician's examination or other concerns
- Surgery scheduled before anticipated study completion
Sites / Locations
- University of British ColumbiaRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Placebo Comparator
Active Comparator
Active Comparator
Experimental
Placebo and Filtered Air
Budesonide and Filtered Air
Placebo and Diesel Exhaust
Budesonide and Diesel Exhaust
Volunteers will use an inhaler that does not contain any medication, before sitting in a booth and being exposed to high-efficiency particulate air (HEPA) filtered air for 2 hours.
Volunteers will inhale 1.6mg of budesonide before sitting in a booth and being exposed to HEPA filtered air for 2 hours.
Volunteers will use an inhaler that does not contain any medication, before sitting in a booth and being exposed to 300µg/m³ concentration of diesel exhaust for 2 hours.
Volunteers will inhale 1.6mg of budesonide before sitting in a booth and being exposed to 300µg/m³ concentration of diesel exhaust for 2 hours.