Repetitive Transcranial Magnetic Stimulation as Therapy in Hereditary Spastic Paraplegia and Adrenomyeloneuropathy
Hereditary Spastic Paraplegia, Adrenomyeloneuropathy
About this trial
This is an interventional treatment trial for Hereditary Spastic Paraplegia focused on measuring Hereditary spastic paraplegia, repetitive transcranial magnetic stimulation, disturbed gait, Adrenomyeloneuropthy
Eligibility Criteria
Inclusion Criteria:
- diagnosis of hereditary spastic paraplegia - confirmed genetically, on the basis of family history or on exclusion or diagnosis of adrenomyeloneuropathy - confirmed genetically or by the elevated plasma very long chain fatty acid or on family history
- Gait disturbances affecting daily activities
- Ability to walk 10 meters without assistance or with crutches or with rollator walker
Exclusion Criteria:
- Presence of signs or symptoms indicating other than HSP or AMN ethiology of gait disturbances
- Contraindications for rTMS as listed by the Guidelines of the International Federation of Clinical Neurophysiology (IFCN 2009) i.e. seizure in the past, epilepsy, presence of magnetic material in the reach of magnetic field, pregnancy, likelihood to get pregnant, intracranial electrodes, cardiac pacemaker or intracardiac lines, frequent syncopes
Sites / Locations
- Jagiellonian University Medical College, Department of Neurology
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
active rTMS
Sham rTMS
10 hertz (Hz) rTMS will be administered over bilateral primary motor areas for the muscles of lower extremities. Therapy will include five daily sessions (on consecutive week days). In every sessions 3000 magnetic pulses of 90% of the resting motor threshold intensity will be elicited.
Sham stimulation will mimic the active one except that the stimulating coil will be held perpendicularly to the scalp, which assures similar impression as the active stimulation but prevents that significant magnetic field will reach brain tissue.