Vitamin C, Steroids, and Thiamine, and Cerebral Autoregulation and Functional Outcome in Septic Shock (CORVICTES-ΥΜ)
Septic Shock
About this trial
This is an interventional treatment trial for Septic Shock focused on measuring Shock, Septic, Cerebrovascular Circulation, Spectroscopy, Near-Infrared, Patient Reported Outcome Measure
Eligibility Criteria
Inclusion Criteria:
• Diagnosis of septic shock within 12 hours of admission to the intensive care unit (ICU).
Exclusion Criteria:
- Age < 18 years
- Pregnancy
- Patients with a fatal underlying disease who are unlikely to survive to hospital discharge
- Patients with acquired immunodeficiency and a CD4 count of < 50 / μL
- Patients with known glucose-6 phosphate dehydrogenase (G-6PD) deficiency.
- Patients with sepsis/septic shock transferred from another hospital
- Patients with features of sepsis/septic shock > 12 hours
- Patients who require treatment with corticosteroids for an indication other than sepsis
- Patients with any history of an allergic reaction
Sites / Locations
- Evaggelismos General HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Steroids/Vitamin C group
Control group
"Combined Vitamin C and Stress-Dose Hydrocortisone": Patients with septic shock treated with 1500 mg Vitamin C every 6 hours for 4 days after randomization, and stress-dose hydrocortisone for 4 days (250 mg on day 1; and 200 mg on days 2, 3, and 4) after randomization.
"Placebo plus placebo:" Patients with septic shock treated with placebo (corresponding to Vitamin C) and placebo (corresponding to hydrocortisone) for 4 days after randomization.