Childhood Convulsive Status Epilepticus Management In A Resource Limited Setting
Pediatric Status Epilepticus
About this trial
This is an interventional treatment trial for Pediatric Status Epilepticus
Eligibility Criteria
Inclusion Criteria:
- Children in convulsive status epilepticus (as defined by Trinka et al 2015)
Exclusion Criteria:
- Children not in convulsive status epilepticus
Sites / Locations
- Red Cross War Memorial Children's Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Phenobarbital
Phenytoin / Midazolam infusion
If allocated to this arm 'Phenobarbital' (PHB group), the clinician gives an IV bolus of phenobarbital (20mg/kg ). If CSE did not terminate after 5 - 10 minutes, a second dose is given at half the dosage (10mg/kg) and a third dose (10mg/kg) is given if CSE persists 5-10 minutes after that.
In the 'Phenytoin / Midazolam infusion' (PHY/MDZ group), children are given a dose (20mg/kg) of IV phenytoin mixed with 50mL of normal saline solution and administered over 30 minutes . If the child is still in CSE 5-10 minutes after the phenytoin is given, they then start on a midazolam infusion. This includes a loading dose of IV midazolam (0.2mg/kg) followed by an infusion set at 3mg/kg into 50mL 5% dextrose water given at a rate of 1-4 mL/hour (equivalent to 1-4 mcg/kg/min ).