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KRT-232 Versus Best Available Therapy for the Treatment of Subjects With Myelofibrosis Who Are Relapsed or Refractory to JAK Inhibitor Treatment (BOREAS)

Primary Purpose

Primary Myelofibrosis (PMF), Post-Polycythemia Vera MF (Post-PV-MF), Post-Essential Thrombocythemia MF (Post-ET-MF)

Status
Recruiting
Phase
Phase 2
Locations
International
Study Type
Interventional
Intervention
KRT-232
Best Available Therapy (BAT)
Sponsored by
Kartos Therapeutics, Inc.
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Primary Myelofibrosis (PMF) focused on measuring navtemadlin

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Confirmed diagnosis of PMF, post-PV MF or post-ET MF (WHO)
  • High, intermediate-2, or intermediate-1 risk Dynamic International Prognostic System (DIPSS)
  • Failure of prior treatment with JAK inhibitor
  • ECOG ≤ 2

Exclusion Criteria:

  • Prior splenectomy
  • Splenic irradiation within 3 months prior to randomization
  • History of major hemorrhage or intracranial hemorrhage within 6 months prior to randomization
  • History of stroke, reversible ischemic neurological defect or transient ischemic attack within 6 months prior to randomization
  • Prior MDM2 inhibitor therapy or p53-directed therapy
  • Prior allogeneic stem-cell transplant or plans for allogeneic stem cell transplant
  • History of major organ transplant
  • Grade 2 or higher QTc prolongation (> 480 milliseconds per NCI-CTCAE criteria, version 5.0)

Sites / Locations

  • The Kirklin Clinic of UAB Hospital
  • University of Southern California Norris Comprehensive Cancer Center
  • Stanford Cancer Center - Palo Alto
  • Innovative Clinical Research Institute
  • University Cancer Institute
  • Northwestern University Feinberg School of Medicine
  • University of Illinois at ChicagoRecruiting
  • Dana-Farber Cancer Institute
  • Washington University School of MedicineRecruiting
  • Brookdale University Hospital and Medical CenterRecruiting
  • New York Presbyterian/Weill Cornell Medical Center
  • Mt. SinaiRecruiting
  • Gabrail Cancer CenterRecruiting
  • The Ohio State University Comprehensive Cancer Center
  • Oregon Health and Science University
  • Avera Cancer InstituteRecruiting
  • Vanderbilt University Medical CenterRecruiting
  • The University of Texas MD Anderson Cancer CenterRecruiting
  • Medical College of Wisconsin - Froedtert HospitalRecruiting
  • Sanatorio de la MujerRecruiting
  • Instituto Medico Alexander FlemingRecruiting
  • Centro Medico San LuisRecruiting
  • Hospital Privado - Centro Medico de Cordoba - OncologyRecruiting
  • Monash Medical CentreRecruiting
  • Fiona Stanley HositalRecruiting
  • Royal Adelaide HospitalRecruiting
  • The Alfred HospitalRecruiting
  • South Eastern Private HospitalRecruiting
  • Icon Cancer CenterRecruiting
  • Centro de oncologia Leonardo da VinciRecruiting
  • Hospital Erasto GaertnerRecruiting
  • UNICAMP - Universidade Estadual de Campinas HemocentroRecruiting
  • Hospital das Clínicas UFGRecruiting
  • Fundacao Doutor Amaral CarvalhoRecruiting
  • Hospital de Clinicas de Porto Alegre - Centro de Pesquisa ClinicaRecruiting
  • Associação Educadora São Carlos AESC - Hospital Mãe de Deus - Centro de PesquisaRecruiting
  • Instituto de Ensino e Pesquisa São LucasRecruiting
  • Hospital A C Camargo - Fundacao Antonio PrudenteRecruiting
  • Hospital das Clínicas da Universidade de São PauloRecruiting
  • Instituto D'or de Pesquisa e EnsinoRecruiting
  • Instituto COI São PauloRecruiting
  • University Multiprofile Hospital for Active Treatment Dr. Georgi Stranski, PlevenRecruiting
  • University Multiprofile Hospital for Active Treatment Sveti Georgi, PlovdivRecruiting
  • Military Medical Academy, Multiprofile for active treatment, SofiaRecruiting
  • Acibadem City Clinic Tokuda Hospital, SofiaRecruiting
  • Specialized Hospital for Active Therapy of Hematological DisordersRecruiting
  • University Multiprofile Hospital for Active Treatment Alexandrovska, Sofia
  • University Multiprofile Hospital for Active Treatment Saint Ivan Rilski, SofiaRecruiting
  • Princess Margaret Cancer Center
  • General Hospital SibenikRecruiting
  • Clinical Hospital Centre OsijekRecruiting
  • KB Sestre MilosrdniceRecruiting
  • FN Hradec KraloveRecruiting
  • Vseonecma fakultni nemocrince V PrazeRecruiting
  • Fakultní Nemocnice Olomouc
  • Centre Hospitalier Universitaire D'Amiens (Hopital Sud) - Hématologie CliniqueRecruiting
  • Center Hospitalier Universitaire d'AngersRecruiting
  • C.H de la Côte Basque - ServivRecruiting
  • Centre Hospitalier Regional Universitaire Brest Hopital MorvanRecruiting
  • Centre Hospitalier Universitaire of Caen Normandie - Côte de Nacre
  • Centre Hospitalier Le MansRecruiting
  • Centre Hospitalier Universitaire de Nîmes
  • Hôpital Saint-LouisRecruiting
  • Centre Hospitalier Universitaire de PoitiersRecruiting
  • Institut Universitaire du Cancer de Toulouse OncopoleRecruiting
  • Hopital Paul Brousse - Aphp Hôpitaux Universitaires Paris SuRecruiting
  • Klinikum Rechts der Isar der Technischen Universität München ApothekeRecruiting
  • Universitätsklinikum Aachen
  • Universitaetsklinikum EssenRecruiting
  • Universitätsklinikum HalleRecruiting
  • Gemeinschaftspraxis Haematologie - Onkologie - HauptstelleRecruiting
  • Technische Universität DresdenRecruiting
  • Universitätsklinikum JenaRecruiting
  • Charité Universitätsmedizin BerlinRecruiting
  • UKE - Universitätsklinikum Hamburg-EppendorfRecruiting
  • Universitätsmedizin der Johannes Gutenberg Universität Mainz
  • Stauferklinikum Schwäbisch GmündRecruiting
  • Praxis für Hämatologie und OnkologieRecruiting
  • University General Hospital of IoanninaRecruiting
  • University Campus of Patras - HematologyRecruiting
  • AHEPA General Hospital of ThessalonikiRecruiting
  • Queen Mary HospitalRecruiting
  • Prince of Wales Hospital - MedicineRecruiting
  • Somogy Megyei Kaposi Mór Oktató Kórház
  • Szabolcs-Szatmár-Bereg Megyei Kórházak és Egyetemi OktatókórházRecruiting
  • Markusovszky Egyetemi OktatókórházRecruiting
  • Semmelweis Egyetem
  • Dél-pesti Centrumkórház - Országos Hematológiai és Infektológiai IntézetRecruiting
  • Debreceni Egyetem Orvos es Egeszsegtudomanyi Centrum
  • Szegedi TudományegyetemRecruiting
  • Ha'Emek Medical CenterRecruiting
  • Assuta Ashdod University HospitalRecruiting
  • Rambam Medical CentreRecruiting
  • Carmel MCRecruiting
  • Hadassah Medical OrganisationRecruiting
  • Hematology InstituteRecruiting
  • Western Galilee Hospital - NahariyaRecruiting
  • Rabin Medical Center - Beilinson HospitalRecruiting
  • Tel Aviv Sourasky Medical Center - OncologyRecruiting
  • Assuta MCRecruiting
  • Assaf Harofeh Medical Center - HematologyRecruiting
  • A.O. San Gerardo di Monza - L'Ospedale San Gerardo di Monza e l'Università di MilanoRecruiting
  • PO Civile SS.Antonio e BiagioRecruiting
  • AOU Ospedali Riuniti Umberto I G.M. Lancisi G. SalesiRecruiting
  • A.O.di Bologna Policl.S.OrsolaRecruiting
  • AO Spedali Civili di BresciaRecruiting
  • Azienda Ospedaliero Universitaria Policlinico - Vittorio EmanueleRecruiting
  • AOU CareggiRecruiting
  • Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST IRCCSRecruiting
  • Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' GrandaRecruiting
  • ASST Grande Ospedale Metropolitano NiguardaRecruiting
  • AOU Maggiore della CaritàRecruiting
  • Azienda Ospedaliera Ospedali Riuniti Marche Nord - PesaroRecruiting
  • Arcispedale S. Maria Nuova, AO di Reggio EmiliaRecruiting
  • Policlinico Universitario Agostino GemelliRecruiting
  • A.O. Citta della Salute e della Scienza di TorinoRecruiting
  • Inje University Busan Paik HospitalRecruiting
  • Kyungpook National University HospitalRecruiting
  • Yeungnam University Medical CenterRecruiting
  • Keimyung University Dongsan Medical CenterRecruiting
  • CHA Bundang Medical Center, CHA UniversityRecruiting
  • Seoul National University HospitalRecruiting
  • Samsung Medical CenterRecruiting
  • The Catholic University of Korea, Seoul St. Mary's HospitalRecruiting
  • Hospital of Lithuanian University of Health Sciences KaunasRecruiting
  • Universidad Autonoma de Nuevo Leon (UANL) - Hospital Universitario "Dr. Jose Eleuterio GonzalezRecruiting
  • Instituto Mexicano del Seguro SocialRecruiting
  • Oaxaca Site Management Organization OSMORecruiting
  • Sociedad de Metabolismo y Corazón S.C. - OncologyRecruiting
  • Perpetual Succour Hospital - Hemat/Transfusion MedRecruiting
  • University of the Philippines - Philippine General HospitalRecruiting
  • Dolnośląskie Centrum Transplantacji Komórkowych z Krajowym Bankiem Dawców SzpikuRecruiting
  • Szpital Specjalistyczny w Brzozowie Podkarpacki Ośrodek Onkologiczny im. Ks. B. Markiewicza
  • Samodzielny Publiczny Zakład Opieki Zdrowotnej Zespół Szpitali MiejskichRecruiting
  • Szpital Uniwersytecki nr 2 im dr. Jana BizielaRecruiting
  • Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie
  • SPZOZ MSWiA z Warminsko - Mazurskim Centrum OnkologiiRecruiting
  • Szpital Wojewódzki w OpoluRecruiting
  • Clinical Research Center Spółka z Ograniczoną Odpowiedzialnością Medic-R sp. k.
  • Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka w Slupsku Sp. z o.o.Recruiting
  • H. Infante Dom Pedro. Centro Hospitalar do Baixo VougaRecruiting
  • Hospital de BragaRecruiting
  • Instituto Português de Oncologia de CoimbraRecruiting
  • H. São Francisco Xavier-Centro Hospitalar Lisboa OcidentalRecruiting
  • Champalimaud Cancer CenterRecruiting
  • Cen Med de Diagn si Trat Amb NEOMEDRecruiting
  • Spitalul Clinic ColentinaRecruiting
  • Spitalul Clinic ColteaRecruiting
  • MedicoverRecruiting
  • Institutul Oncologic "Prof. Dr. Ion Chiricuta"Recruiting
  • Spitalul Clinic Municipal Filantropia CraiovaRecruiting
  • Institutul Regional de Oncologie IasiRecruiting
  • Spitalul Clinic Municipal de Urgenta TimisoaraRecruiting
  • OncomedRecruiting
  • Spitalul Clinic Judetean de Urgenta Tg MuresRecruiting
  • Clinical oncological dispensary
  • Saint-Petersburg SMU I.P.Pavlov
  • Oncologic dispensary of Komi Republic
  • Hospital Universitari Germans Trias i PujolRecruiting
  • Hospital Universitario de Gran Canaria Doctor NegrinRecruiting
  • Hospital Universitario Puerta de Hierro - Majadahonda
  • Hospital Universitario Vall d'HebrónRecruiting
  • Hospital de La Santa Creu i Sant PauRecruiting
  • Hospital San Pedro de AlcantaraRecruiting
  • Hospital Universitario Virgen de la VictoriaRecruiting
  • Hospital Universitario Son EspasesRecruiting
  • Complejo Hospitalario de Navarra - H. de Navarra, Hematología C/ de Irunlarrea, 3, PamplonaRecruiting
  • Hospital Universitario de SalamancaRecruiting
  • Hospital Universitario Doctor PesetRecruiting
  • H. Quirón ZaragozaRecruiting
  • National Taiwan University HospitalRecruiting
  • Chang Gung Medical Foundation - ChiaYi Chang Gung Memorial Hospital - Chiayi BranchRecruiting
  • Kaohsiung Medical University - Chung-Ho Memorial HospitalRecruiting
  • China Medical University HospitalRecruiting
  • Ramathibodi Hospital - Mahidol University - HematologyRecruiting
  • Siriraj HospitalRecruiting
  • Thammasat University HospitalRecruiting
  • Srinagarind Hospital (KhonKaen University)Recruiting
  • Songklanagarind HospitalRecruiting
  • Sakarya Research and Training HospitalRecruiting
  • Ankara University Faculty of MedicineRecruiting
  • Gazi University Medical FacultyRecruiting
  • Pamukkale UniversityRecruiting
  • Gaziantep University Faculty of MedicineRecruiting
  • Inonu University Turgut Ozal Medical CenterRecruiting
  • Mersin University Medical FacultyRecruiting
  • Ondokuz Mayis University Medical Faculty - HematologyRecruiting
  • University Hospitals Birmingham NHS Foundation Trust
  • NHS Greater Glasgow and Clyde
  • Guy's and Saint Thomas' NHS Foundation Trust
  • Oxford University Hospitals NHS Foundation Trust

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm 4

Arm 5

Arm 6

Arm Type

Experimental

Experimental

Experimental

Experimental

Experimental

Active Comparator

Arm Label

Part A Cohort 1

Part A Cohort 2

Part A Cohort 3

Part A Cohort 4b

Part B Arm 1 KRT-232

Part B Arm 2 Best Available Therapy

Arm Description

KRT-232 120 mg by mouth once daily for Days 1-7, off treatment for Days 8-21 (21-day cycles)

KRT-232 240 mg by mouth once daily for Days 1-7, off treatment for Days 8-21 (21-day cycles)

KRT-232 240 mg by mouth once daily for Days 1-7, off treatment for Days 8-28 (28-day cycles)

KRT-232 240 mg by mouth once daily for Days 1-5, off treatment for Days 6-28 (28-day cycles)

KRT-232 240 mg by mouth once daily for Days 1-7, off treatment for Days 8-28 (28-day cycles)

Best available therapy at the discretion of the investigator, on a 28-day cycle.

Outcomes

Primary Outcome Measures

(Part A Only) Spleen Volume Reduction (SVR)
The proportion of subjects achieving a ≥ 35% spleen volume reduction (SVR) from Baseline to Week 24, as assessed by magnetic resonance imaging (MRI) or computed tomography (CT) scan
(Part B Only) Spleen Volume Reduction (SVR)
The proportion of subjects achieving SVR of ≥ 35% at Week 24 by MRI/CT scan (central review)

Secondary Outcome Measures

(Part A only) Improvement in Total Symptom Score (TSS)
The proportion of subjects who have at least a 50% reduction from Baseline to Week 24 and Week 48 in the total symptom score as measured by the modified MPN-SAF v2.0
(Part B only) Improvement of Total Symptom Score (TSS)
The proportion of subjects who have at least a 50% reduction from Baseline to Week 24 in the total symptom score as measured by the MF-SAF v4.0
(Part B only) Overall Survival (OS)
Time from randomization to death from any cause
(Part B only) Progression free survival (PFS)
Time from randomization to either first occurrence of disease progression or death due to any cause
(Part B Only) Overall Spleen Volume Reduction (SVR)
The proportion of subjects in each arm achieving SVR of ≥ 35% at any time by MRI/CT scan (central review)
(Part B Only) Spleen Response Duration
Time from initial SVR of ≥ 35% by MRI/CT (central review) until the first occurrence of disease progression
(Part B Only) Rate of conversion from RBC transfusion dependent to independent
The proportion of subjects who have RBC transfusion independence at week 24

Full Information

First Posted
September 5, 2018
Last Updated
April 26, 2023
Sponsor
Kartos Therapeutics, Inc.
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1. Study Identification

Unique Protocol Identification Number
NCT03662126
Brief Title
KRT-232 Versus Best Available Therapy for the Treatment of Subjects With Myelofibrosis Who Are Relapsed or Refractory to JAK Inhibitor Treatment
Acronym
BOREAS
Official Title
A Phase 2/3 Randomized, Controlled, Open-Label Study of KRT 232 in Subjects With Primary Myelofibrosis (PMF), Post Polycythemia Vera MF (Post-PV-MF), Or Post Essential Thrombocythemia MF (Post-ET-MF) Who Are Relapsed or Refractory to Janus Kinase (JAK) Inhibitor Treatment
Study Type
Interventional

2. Study Status

Record Verification Date
April 2023
Overall Recruitment Status
Recruiting
Study Start Date
January 15, 2019 (Actual)
Primary Completion Date
December 31, 2023 (Anticipated)
Study Completion Date
December 31, 2025 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Kartos Therapeutics, Inc.

4. Oversight

Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Product Manufactured in and Exported from the U.S.
Yes
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, for the treatment of patients with myelofibrosis (MF) who no longer benefit from treatment with a JAK inhibitor. Inhibition of MDM2 is a novel mechanism of action in MF. This study will be conducted in 2 phases. Phase 2 will determine the KRT-232 recommended dose and dosing schedule; Phase 3 will test KRT-232 vs Best Available Therapy (BAT). Patients in the Phase 3 part of the study will be randomized 2:1 to receive either KRT-232 (Arm 1) or BAT (Arm 2). The BAT administered will be determined by the treating physician, with the option to "cross-over" to KRT-232 treatment after 6 months of BAT or if the disease worsens at any time.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Primary Myelofibrosis (PMF), Post-Polycythemia Vera MF (Post-PV-MF), Post-Essential Thrombocythemia MF (Post-ET-MF)
Keywords
navtemadlin

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 2, Phase 3
Interventional Study Model
Crossover Assignment
Masking
Outcomes Assessor
Allocation
Randomized
Enrollment
385 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Part A Cohort 1
Arm Type
Experimental
Arm Description
KRT-232 120 mg by mouth once daily for Days 1-7, off treatment for Days 8-21 (21-day cycles)
Arm Title
Part A Cohort 2
Arm Type
Experimental
Arm Description
KRT-232 240 mg by mouth once daily for Days 1-7, off treatment for Days 8-21 (21-day cycles)
Arm Title
Part A Cohort 3
Arm Type
Experimental
Arm Description
KRT-232 240 mg by mouth once daily for Days 1-7, off treatment for Days 8-28 (28-day cycles)
Arm Title
Part A Cohort 4b
Arm Type
Experimental
Arm Description
KRT-232 240 mg by mouth once daily for Days 1-5, off treatment for Days 6-28 (28-day cycles)
Arm Title
Part B Arm 1 KRT-232
Arm Type
Experimental
Arm Description
KRT-232 240 mg by mouth once daily for Days 1-7, off treatment for Days 8-28 (28-day cycles)
Arm Title
Part B Arm 2 Best Available Therapy
Arm Type
Active Comparator
Arm Description
Best available therapy at the discretion of the investigator, on a 28-day cycle.
Intervention Type
Drug
Intervention Name(s)
KRT-232
Intervention Description
KRT-232, administered by mouth
Intervention Type
Drug
Intervention Name(s)
Best Available Therapy (BAT)
Intervention Description
Best available therapy options include: hydroxyurea chemotherapy or supportive care (including but not limited to corticosteroids and androgens; JAK inhibitors not allowed).
Primary Outcome Measure Information:
Title
(Part A Only) Spleen Volume Reduction (SVR)
Description
The proportion of subjects achieving a ≥ 35% spleen volume reduction (SVR) from Baseline to Week 24, as assessed by magnetic resonance imaging (MRI) or computed tomography (CT) scan
Time Frame
24 weeks
Title
(Part B Only) Spleen Volume Reduction (SVR)
Description
The proportion of subjects achieving SVR of ≥ 35% at Week 24 by MRI/CT scan (central review)
Time Frame
24 Weeks
Secondary Outcome Measure Information:
Title
(Part A only) Improvement in Total Symptom Score (TSS)
Description
The proportion of subjects who have at least a 50% reduction from Baseline to Week 24 and Week 48 in the total symptom score as measured by the modified MPN-SAF v2.0
Time Frame
48 weeks
Title
(Part B only) Improvement of Total Symptom Score (TSS)
Description
The proportion of subjects who have at least a 50% reduction from Baseline to Week 24 in the total symptom score as measured by the MF-SAF v4.0
Time Frame
24 Weeks
Title
(Part B only) Overall Survival (OS)
Description
Time from randomization to death from any cause
Time Frame
48 months
Title
(Part B only) Progression free survival (PFS)
Description
Time from randomization to either first occurrence of disease progression or death due to any cause
Time Frame
48 months
Title
(Part B Only) Overall Spleen Volume Reduction (SVR)
Description
The proportion of subjects in each arm achieving SVR of ≥ 35% at any time by MRI/CT scan (central review)
Time Frame
48 months
Title
(Part B Only) Spleen Response Duration
Description
Time from initial SVR of ≥ 35% by MRI/CT (central review) until the first occurrence of disease progression
Time Frame
48 months
Title
(Part B Only) Rate of conversion from RBC transfusion dependent to independent
Description
The proportion of subjects who have RBC transfusion independence at week 24
Time Frame
24 weeks

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Confirmed diagnosis of PMF, post-PV MF or post-ET MF (WHO) High, intermediate-2, or intermediate-1 risk Dynamic International Prognostic System (DIPSS) Failure of prior treatment with JAK inhibitor ECOG ≤ 2 Exclusion Criteria: Prior splenectomy Splenic irradiation within 3 months prior to randomization History of major hemorrhage or intracranial hemorrhage within 6 months prior to randomization History of stroke, reversible ischemic neurological defect or transient ischemic attack within 6 months prior to randomization Prior MDM2 inhibitor therapy or p53-directed therapy Prior allogeneic stem-cell transplant or plans for allogeneic stem cell transplant History of major organ transplant Grade 2 or higher QTc prolongation (> 480 milliseconds per NCI-CTCAE criteria, version 5.0)
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
John Mei
Phone
650-542-0136
Email
jmei@kartosthera.com
First Name & Middle Initial & Last Name or Official Title & Degree
Yulia Khalina
Phone
908-656-2799
Email
ykhalina@kartosthera.com
Facility Information:
Facility Name
The Kirklin Clinic of UAB Hospital
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35294
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
University of Southern California Norris Comprehensive Cancer Center
City
Los Angeles
State/Province
California
ZIP/Postal Code
90033
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Stanford Cancer Center - Palo Alto
City
Stanford
State/Province
California
ZIP/Postal Code
94305
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Innovative Clinical Research Institute
City
Whittier
State/Province
California
ZIP/Postal Code
90603
Country
United States
Individual Site Status
Completed
Facility Name
University Cancer Institute
City
Boynton Beach
State/Province
Florida
ZIP/Postal Code
33426
Country
United States
Individual Site Status
Withdrawn
Facility Name
Northwestern University Feinberg School of Medicine
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60611
Country
United States
Individual Site Status
Completed
Facility Name
University of Illinois at Chicago
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Individual Site Status
Recruiting
Facility Name
Dana-Farber Cancer Institute
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02215
Country
United States
Individual Site Status
Withdrawn
Facility Name
Washington University School of Medicine
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Individual Site Status
Recruiting
Facility Name
Brookdale University Hospital and Medical Center
City
Brooklyn
State/Province
New York
ZIP/Postal Code
11212
Country
United States
Individual Site Status
Recruiting
Facility Name
New York Presbyterian/Weill Cornell Medical Center
City
New York
State/Province
New York
ZIP/Postal Code
10021
Country
United States
Individual Site Status
Withdrawn
Facility Name
Mt. Sinai
City
New York
State/Province
New York
ZIP/Postal Code
10029
Country
United States
Individual Site Status
Recruiting
Facility Name
Gabrail Cancer Center
City
Canton
State/Province
Ohio
ZIP/Postal Code
44718
Country
United States
Individual Site Status
Recruiting
Facility Name
The Ohio State University Comprehensive Cancer Center
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43210
Country
United States
Individual Site Status
Completed
Facility Name
Oregon Health and Science University
City
Portland
State/Province
Oregon
ZIP/Postal Code
97239
Country
United States
Individual Site Status
Completed
Facility Name
Avera Cancer Institute
City
Sioux Falls
State/Province
South Dakota
ZIP/Postal Code
57105
Country
United States
Individual Site Status
Recruiting
Facility Name
Vanderbilt University Medical Center
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37203
Country
United States
Individual Site Status
Recruiting
Facility Name
The University of Texas MD Anderson Cancer Center
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Individual Site Status
Recruiting
Facility Name
Medical College of Wisconsin - Froedtert Hospital
City
Milwaukee
State/Province
Wisconsin
ZIP/Postal Code
53226
Country
United States
Individual Site Status
Recruiting
Facility Name
Sanatorio de la Mujer
City
Rosario
State/Province
Santa Fe
ZIP/Postal Code
S2000ORE
Country
Argentina
Individual Site Status
Recruiting
Facility Name
Instituto Medico Alexander Fleming
City
Buenos Aires
Country
Argentina
Individual Site Status
Recruiting
Facility Name
Centro Medico San Luis
City
Caba
ZIP/Postal Code
1425
Country
Argentina
Individual Site Status
Recruiting
Facility Name
Hospital Privado - Centro Medico de Cordoba - Oncology
City
Córdoba
ZIP/Postal Code
X5016KEH
Country
Argentina
Individual Site Status
Recruiting
Facility Name
Monash Medical Centre
City
Clayton
State/Province
Victoria
ZIP/Postal Code
3168
Country
Australia
Individual Site Status
Recruiting
Facility Name
Fiona Stanley Hosital
City
Murdoch
State/Province
Western Australia
ZIP/Postal Code
6150
Country
Australia
Individual Site Status
Recruiting
Facility Name
Royal Adelaide Hospital
City
Adelaide
Country
Australia
Individual Site Status
Recruiting
Facility Name
The Alfred Hospital
City
Melbourne
Country
Australia
Individual Site Status
Recruiting
Facility Name
South Eastern Private Hospital
City
Noble Park
ZIP/Postal Code
3174
Country
Australia
Individual Site Status
Recruiting
Facility Name
Icon Cancer Center
City
South Brisbane
Country
Australia
Individual Site Status
Recruiting
Facility Name
Centro de oncologia Leonardo da Vinci
City
Fortaleza
State/Province
Ceara
ZIP/Postal Code
60140-025
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Hospital Erasto Gaertner
City
Curitiba
State/Province
Parana
ZIP/Postal Code
81520
Country
Brazil
Individual Site Status
Recruiting
Facility Name
UNICAMP - Universidade Estadual de Campinas Hemocentro
City
Campinas
State/Province
São Paulo
ZIP/Postal Code
13083
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Hospital das Clínicas UFG
City
Goiânia
ZIP/Postal Code
74605
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Fundacao Doutor Amaral Carvalho
City
Jau
ZIP/Postal Code
17210-120
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Hospital de Clinicas de Porto Alegre - Centro de Pesquisa Clinica
City
Porto Alegre
ZIP/Postal Code
90035-903
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Associação Educadora São Carlos AESC - Hospital Mãe de Deus - Centro de Pesquisa
City
Porto Alegre
ZIP/Postal Code
90880-480
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Instituto de Ensino e Pesquisa São Lucas
City
Sao Paulo
ZIP/Postal Code
01236-030
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Hospital A C Camargo - Fundacao Antonio Prudente
City
Sao Paulo
ZIP/Postal Code
01509-900
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Hospital das Clínicas da Universidade de São Paulo
City
Sao Paulo
ZIP/Postal Code
05403-000
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Instituto D'or de Pesquisa e Ensino
City
São Paulo
ZIP/Postal Code
04502-001
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Instituto COI São Paulo
City
São Paulo
ZIP/Postal Code
1321001
Country
Brazil
Individual Site Status
Recruiting
Facility Name
University Multiprofile Hospital for Active Treatment Dr. Georgi Stranski, Pleven
City
Pleven
Country
Bulgaria
Individual Site Status
Recruiting
Facility Name
University Multiprofile Hospital for Active Treatment Sveti Georgi, Plovdiv
City
Plovdiv
Country
Bulgaria
Individual Site Status
Recruiting
Facility Name
Military Medical Academy, Multiprofile for active treatment, Sofia
City
Sofia
ZIP/Postal Code
1606
Country
Bulgaria
Individual Site Status
Recruiting
Facility Name
Acibadem City Clinic Tokuda Hospital, Sofia
City
Sofia
Country
Bulgaria
Individual Site Status
Recruiting
Facility Name
Specialized Hospital for Active Therapy of Hematological Disorders
City
Sofia
Country
Bulgaria
Individual Site Status
Recruiting
Facility Name
University Multiprofile Hospital for Active Treatment Alexandrovska, Sofia
City
Sofia
Country
Bulgaria
Individual Site Status
Withdrawn
Facility Name
University Multiprofile Hospital for Active Treatment Saint Ivan Rilski, Sofia
City
Sofia
Country
Bulgaria
Individual Site Status
Recruiting
Facility Name
Princess Margaret Cancer Center
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5G 2M9
Country
Canada
Individual Site Status
Active, not recruiting
Facility Name
General Hospital Sibenik
City
Sibenik
ZIP/Postal Code
22000
Country
Croatia
Individual Site Status
Recruiting
Facility Name
Clinical Hospital Centre Osijek
City
Zagreb
ZIP/Postal Code
10000
Country
Croatia
Individual Site Status
Recruiting
Facility Name
KB Sestre Milosrdnice
City
Zagreb
ZIP/Postal Code
10000
Country
Croatia
Individual Site Status
Recruiting
Facility Name
FN Hradec Kralove
City
Králová
ZIP/Postal Code
500 05
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Vseonecma fakultni nemocrince V Praze
City
Nové Město
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Fakultní Nemocnice Olomouc
City
Olomouc
ZIP/Postal Code
779 00
Country
Czechia
Individual Site Status
Withdrawn
Facility Name
Centre Hospitalier Universitaire D'Amiens (Hopital Sud) - Hématologie Clinique
City
Amiens
ZIP/Postal Code
80054
Country
France
Individual Site Status
Recruiting
Facility Name
Center Hospitalier Universitaire d'Angers
City
Angers
ZIP/Postal Code
49933 Cedex 09
Country
France
Individual Site Status
Recruiting
Facility Name
C.H de la Côte Basque - Serviv
City
Bayonne
ZIP/Postal Code
64100
Country
France
Individual Site Status
Recruiting
Facility Name
Centre Hospitalier Regional Universitaire Brest Hopital Morvan
City
Brest Cedex
ZIP/Postal Code
29609
Country
France
Individual Site Status
Recruiting
Facility Name
Centre Hospitalier Universitaire of Caen Normandie - Côte de Nacre
City
Caen
ZIP/Postal Code
14000
Country
France
Individual Site Status
Active, not recruiting
Facility Name
Centre Hospitalier Le Mans
City
Le Mans
Country
France
Individual Site Status
Recruiting
Facility Name
Centre Hospitalier Universitaire de Nîmes
City
Nîmes
ZIP/Postal Code
30029 Cedex 9
Country
France
Individual Site Status
Active, not recruiting
Facility Name
Hôpital Saint-Louis
City
Paris
ZIP/Postal Code
75010
Country
France
Individual Site Status
Recruiting
Facility Name
Centre Hospitalier Universitaire de Poitiers
City
Poitiers
Country
France
Individual Site Status
Recruiting
Facility Name
Institut Universitaire du Cancer de Toulouse Oncopole
City
Toulouse
ZIP/Postal Code
31059
Country
France
Individual Site Status
Recruiting
Facility Name
Hopital Paul Brousse - Aphp Hôpitaux Universitaires Paris Su
City
Villejuif
ZIP/Postal Code
94800
Country
France
Individual Site Status
Recruiting
Facility Name
Klinikum Rechts der Isar der Technischen Universität München Apotheke
City
München
State/Province
Bayern
ZIP/Postal Code
81675
Country
Germany
Individual Site Status
Recruiting
Facility Name
Universitätsklinikum Aachen
City
Aachen
State/Province
Nordrhein-Westfalen
ZIP/Postal Code
52074
Country
Germany
Individual Site Status
Active, not recruiting
Facility Name
Universitaetsklinikum Essen
City
Essen
State/Province
Nordrhein-Westfalen
ZIP/Postal Code
45147
Country
Germany
Individual Site Status
Recruiting
Facility Name
Universitätsklinikum Halle
City
Halle
State/Province
Sachsen-Anhalt
ZIP/Postal Code
06120
Country
Germany
Individual Site Status
Recruiting
Facility Name
Gemeinschaftspraxis Haematologie - Onkologie - Hauptstelle
City
Dresden
State/Province
Sachsen
ZIP/Postal Code
01307
Country
Germany
Individual Site Status
Recruiting
Facility Name
Technische Universität Dresden
City
Dresden
State/Province
Sachsen
ZIP/Postal Code
01307
Country
Germany
Individual Site Status
Recruiting
Facility Name
Universitätsklinikum Jena
City
Jena
State/Province
Thuringen
ZIP/Postal Code
07747
Country
Germany
Individual Site Status
Recruiting
Facility Name
Charité Universitätsmedizin Berlin
City
Berlin
ZIP/Postal Code
13353
Country
Germany
Individual Site Status
Recruiting
Facility Name
UKE - Universitätsklinikum Hamburg-Eppendorf
City
Hamburg
ZIP/Postal Code
20251
Country
Germany
Individual Site Status
Recruiting
Facility Name
Universitätsmedizin der Johannes Gutenberg Universität Mainz
City
Mainz
Country
Germany
Individual Site Status
Active, not recruiting
Facility Name
Stauferklinikum Schwäbisch Gmünd
City
Mutlangen
ZIP/Postal Code
73557
Country
Germany
Individual Site Status
Recruiting
Facility Name
Praxis für Hämatologie und Onkologie
City
Saarbrücken
ZIP/Postal Code
66113
Country
Germany
Individual Site Status
Recruiting
Facility Name
University General Hospital of Ioannina
City
Ioánnina
State/Province
Ioannina
ZIP/Postal Code
45500
Country
Greece
Individual Site Status
Recruiting
Facility Name
University Campus of Patras - Hematology
City
Patras
ZIP/Postal Code
26504
Country
Greece
Individual Site Status
Recruiting
Facility Name
AHEPA General Hospital of Thessaloniki
City
Thessaloníki
ZIP/Postal Code
54636
Country
Greece
Individual Site Status
Recruiting
Facility Name
Queen Mary Hospital
City
Hong Kong
ZIP/Postal Code
150001
Country
Hong Kong
Individual Site Status
Recruiting
Facility Name
Prince of Wales Hospital - Medicine
City
Shatin
Country
Hong Kong
Individual Site Status
Recruiting
Facility Name
Somogy Megyei Kaposi Mór Oktató Kórház
City
Kaposvár
State/Province
Somogy
ZIP/Postal Code
7400
Country
Hungary
Individual Site Status
Withdrawn
Facility Name
Szabolcs-Szatmár-Bereg Megyei Kórházak és Egyetemi Oktatókórház
City
Nyíregyháza
State/Province
Szabolcs-Szatmar-Bereg
ZIP/Postal Code
4400
Country
Hungary
Individual Site Status
Recruiting
Facility Name
Markusovszky Egyetemi Oktatókórház
City
Szombathely
State/Province
Vas
ZIP/Postal Code
H-9700
Country
Hungary
Individual Site Status
Recruiting
Facility Name
Semmelweis Egyetem
City
Budapest
ZIP/Postal Code
1083
Country
Hungary
Individual Site Status
Withdrawn
Facility Name
Dél-pesti Centrumkórház - Országos Hematológiai és Infektológiai Intézet
City
Budapest
Country
Hungary
Individual Site Status
Recruiting
Facility Name
Debreceni Egyetem Orvos es Egeszsegtudomanyi Centrum
City
Debrecen
ZIP/Postal Code
4032
Country
Hungary
Individual Site Status
Completed
Facility Name
Szegedi Tudományegyetem
City
Szeged
ZIP/Postal Code
6725
Country
Hungary
Individual Site Status
Recruiting
Facility Name
Ha'Emek Medical Center
City
Afula
ZIP/Postal Code
1834111
Country
Israel
Individual Site Status
Recruiting
Facility Name
Assuta Ashdod University Hospital
City
Ashdod
Country
Israel
Individual Site Status
Recruiting
Facility Name
Rambam Medical Centre
City
Haifa
ZIP/Postal Code
31096
Country
Israel
Individual Site Status
Recruiting
Facility Name
Carmel MC
City
Haifa
Country
Israel
Individual Site Status
Recruiting
Facility Name
Hadassah Medical Organisation
City
Jerusalem
ZIP/Postal Code
91120
Country
Israel
Individual Site Status
Recruiting
Facility Name
Hematology Institute
City
Kfar Saba
ZIP/Postal Code
44281
Country
Israel
Individual Site Status
Recruiting
Facility Name
Western Galilee Hospital - Nahariya
City
Nahariya
ZIP/Postal Code
22100
Country
Israel
Individual Site Status
Recruiting
Facility Name
Rabin Medical Center - Beilinson Hospital
City
Petah Tikva
ZIP/Postal Code
49100
Country
Israel
Individual Site Status
Recruiting
Facility Name
Tel Aviv Sourasky Medical Center - Oncology
City
Tel Aviv
ZIP/Postal Code
6423906
Country
Israel
Individual Site Status
Recruiting
Facility Name
Assuta MC
City
Tel Aviv
ZIP/Postal Code
64239
Country
Israel
Individual Site Status
Recruiting
Facility Name
Assaf Harofeh Medical Center - Hematology
City
Zerifin
ZIP/Postal Code
7030000
Country
Israel
Individual Site Status
Recruiting
Facility Name
A.O. San Gerardo di Monza - L'Ospedale San Gerardo di Monza e l'Università di Milano
City
Monza
State/Province
Lombardia
ZIP/Postal Code
20900
Country
Italy
Individual Site Status
Recruiting
Facility Name
PO Civile SS.Antonio e Biagio
City
Alessandria
ZIP/Postal Code
15121
Country
Italy
Individual Site Status
Recruiting
Facility Name
AOU Ospedali Riuniti Umberto I G.M. Lancisi G. Salesi
City
Ancona
ZIP/Postal Code
60123
Country
Italy
Individual Site Status
Recruiting
Facility Name
A.O.di Bologna Policl.S.Orsola
City
Bologna
ZIP/Postal Code
41038
Country
Italy
Individual Site Status
Recruiting
Facility Name
AO Spedali Civili di Brescia
City
Brescia
ZIP/Postal Code
25123
Country
Italy
Individual Site Status
Recruiting
Facility Name
Azienda Ospedaliero Universitaria Policlinico - Vittorio Emanuele
City
Catania
ZIP/Postal Code
95123
Country
Italy
Individual Site Status
Recruiting
Facility Name
AOU Careggi
City
Firenze
ZIP/Postal Code
50141
Country
Italy
Individual Site Status
Recruiting
Facility Name
Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST IRCCS
City
Meldola
Country
Italy
Individual Site Status
Recruiting
Facility Name
Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda
City
Milano
ZIP/Postal Code
20122
Country
Italy
Individual Site Status
Recruiting
Facility Name
ASST Grande Ospedale Metropolitano Niguarda
City
Milano
ZIP/Postal Code
20162
Country
Italy
Individual Site Status
Recruiting
Facility Name
AOU Maggiore della Carità
City
Novara
ZIP/Postal Code
28100
Country
Italy
Individual Site Status
Recruiting
Facility Name
Azienda Ospedaliera Ospedali Riuniti Marche Nord - Pesaro
City
Pesaro
ZIP/Postal Code
61121
Country
Italy
Individual Site Status
Recruiting
Facility Name
Arcispedale S. Maria Nuova, AO di Reggio Emilia
City
Reggio Emilia
ZIP/Postal Code
42123
Country
Italy
Individual Site Status
Recruiting
Facility Name
Policlinico Universitario Agostino Gemelli
City
Roma
ZIP/Postal Code
00168
Country
Italy
Individual Site Status
Recruiting
Facility Name
A.O. Citta della Salute e della Scienza di Torino
City
Torino
ZIP/Postal Code
10126
Country
Italy
Individual Site Status
Recruiting
Facility Name
Inje University Busan Paik Hospital
City
Busan
ZIP/Postal Code
47392
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Kyungpook National University Hospital
City
Daegu
ZIP/Postal Code
41944
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Yeungnam University Medical Center
City
Daegu
ZIP/Postal Code
42415
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Keimyung University Dongsan Medical Center
City
Daegu
ZIP/Postal Code
42601
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
CHA Bundang Medical Center, CHA University
City
Seongnam-si
ZIP/Postal Code
Seongnam-si
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Seoul National University Hospital
City
Seoul
ZIP/Postal Code
03080
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Samsung Medical Center
City
Seoul
ZIP/Postal Code
06351
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
The Catholic University of Korea, Seoul St. Mary's Hospital
City
Seoul
ZIP/Postal Code
6591
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Hospital of Lithuanian University of Health Sciences Kaunas
City
Kaunas
ZIP/Postal Code
LT-50161
Country
Lithuania
Individual Site Status
Recruiting
Facility Name
Universidad Autonoma de Nuevo Leon (UANL) - Hospital Universitario "Dr. Jose Eleuterio Gonzalez
City
Monterrey
State/Province
Nuevo Leon
ZIP/Postal Code
64460
Country
Mexico
Individual Site Status
Recruiting
Facility Name
Instituto Mexicano del Seguro Social
City
Monterrey
ZIP/Postal Code
64180
Country
Mexico
Individual Site Status
Recruiting
Facility Name
Oaxaca Site Management Organization OSMO
City
Oaxaca
ZIP/Postal Code
6800
Country
Mexico
Individual Site Status
Recruiting
Facility Name
Sociedad de Metabolismo y Corazón S.C. - Oncology
City
Veracruz
ZIP/Postal Code
91910
Country
Mexico
Individual Site Status
Recruiting
Facility Name
Perpetual Succour Hospital - Hemat/Transfusion Med
City
Cebu City
ZIP/Postal Code
6000
Country
Philippines
Individual Site Status
Recruiting
Facility Name
University of the Philippines - Philippine General Hospital
City
Manila
ZIP/Postal Code
1000
Country
Philippines
Individual Site Status
Recruiting
Facility Name
Dolnośląskie Centrum Transplantacji Komórkowych z Krajowym Bankiem Dawców Szpiku
City
Wrocław
State/Province
Dolnoslaskie
ZIP/Postal Code
53-439
Country
Poland
Individual Site Status
Recruiting
Facility Name
Szpital Specjalistyczny w Brzozowie Podkarpacki Ośrodek Onkologiczny im. Ks. B. Markiewicza
City
Brzozow
State/Province
Podkarpackie
ZIP/Postal Code
36-200
Country
Poland
Individual Site Status
Active, not recruiting
Facility Name
Samodzielny Publiczny Zakład Opieki Zdrowotnej Zespół Szpitali Miejskich
City
Chorzów
State/Province
Slaskie
ZIP/Postal Code
41-500
Country
Poland
Individual Site Status
Recruiting
Facility Name
Szpital Uniwersytecki nr 2 im dr. Jana Biziela
City
Bydgoszcz
ZIP/Postal Code
86-168
Country
Poland
Individual Site Status
Recruiting
Facility Name
Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie
City
Lublin
ZIP/Postal Code
20-081
Country
Poland
Individual Site Status
Withdrawn
Facility Name
SPZOZ MSWiA z Warminsko - Mazurskim Centrum Onkologii
City
Olsztyn
Country
Poland
Individual Site Status
Recruiting
Facility Name
Szpital Wojewódzki w Opolu
City
Opole
ZIP/Postal Code
45-061
Country
Poland
Individual Site Status
Recruiting
Facility Name
Clinical Research Center Spółka z Ograniczoną Odpowiedzialnością Medic-R sp. k.
City
Poznań
ZIP/Postal Code
60-848
Country
Poland
Individual Site Status
Withdrawn
Facility Name
Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka w Slupsku Sp. z o.o.
City
Słupsk
ZIP/Postal Code
76-200
Country
Poland
Individual Site Status
Recruiting
Facility Name
H. Infante Dom Pedro. Centro Hospitalar do Baixo Vouga
City
Aveiro
ZIP/Postal Code
3814-501
Country
Portugal
Individual Site Status
Recruiting
Facility Name
Hospital de Braga
City
Braga
ZIP/Postal Code
4710-243
Country
Portugal
Individual Site Status
Recruiting
Facility Name
Instituto Português de Oncologia de Coimbra
City
Coimbra
ZIP/Postal Code
3000-075
Country
Portugal
Individual Site Status
Recruiting
Facility Name
H. São Francisco Xavier-Centro Hospitalar Lisboa Ocidental
City
Lisboa
ZIP/Postal Code
1495-005
Country
Portugal
Individual Site Status
Recruiting
Facility Name
Champalimaud Cancer Center
City
Lisbon
ZIP/Postal Code
1400-038
Country
Portugal
Individual Site Status
Recruiting
Facility Name
Cen Med de Diagn si Trat Amb NEOMED
City
Brasov
ZIP/Postal Code
500283
Country
Romania
Individual Site Status
Recruiting
Facility Name
Spitalul Clinic Colentina
City
Bucharest
ZIP/Postal Code
020125
Country
Romania
Individual Site Status
Recruiting
Facility Name
Spitalul Clinic Coltea
City
Bucuresti
ZIP/Postal Code
030171
Country
Romania
Individual Site Status
Recruiting
Facility Name
Medicover
City
Bucuresti
ZIP/Postal Code
060201
Country
Romania
Individual Site Status
Recruiting
Facility Name
Institutul Oncologic "Prof. Dr. Ion Chiricuta"
City
Cluj-Napoca
ZIP/Postal Code
400015
Country
Romania
Individual Site Status
Recruiting
Facility Name
Spitalul Clinic Municipal Filantropia Craiova
City
Craiova
ZIP/Postal Code
200143
Country
Romania
Individual Site Status
Recruiting
Facility Name
Institutul Regional de Oncologie Iasi
City
Iaşi
ZIP/Postal Code
700483
Country
Romania
Individual Site Status
Recruiting
Facility Name
Spitalul Clinic Municipal de Urgenta Timisoara
City
Timişoara
ZIP/Postal Code
300079
Country
Romania
Individual Site Status
Recruiting
Facility Name
Oncomed
City
Timişoara
ZIP/Postal Code
300329
Country
Romania
Individual Site Status
Recruiting
Facility Name
Spitalul Clinic Judetean de Urgenta Tg Mures
City
Târgu-Mureş
ZIP/Postal Code
540136
Country
Romania
Individual Site Status
Recruiting
Facility Name
Clinical oncological dispensary
City
Omsk
ZIP/Postal Code
644013
Country
Russian Federation
Individual Site Status
Withdrawn
Facility Name
Saint-Petersburg SMU I.P.Pavlov
City
St Petersburg
ZIP/Postal Code
197089
Country
Russian Federation
Individual Site Status
Withdrawn
Facility Name
Oncologic dispensary of Komi Republic
City
Syktyvkar
ZIP/Postal Code
167904
Country
Russian Federation
Individual Site Status
Withdrawn
Facility Name
Hospital Universitari Germans Trias i Pujol
City
Badalona
State/Province
Barcelona
ZIP/Postal Code
08916
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitario de Gran Canaria Doctor Negrin
City
Las Palmas De Gran Canaria
State/Province
Las Palmas
ZIP/Postal Code
35010
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitario Puerta de Hierro - Majadahonda
City
Majadahonda
State/Province
Madrid
ZIP/Postal Code
28222
Country
Spain
Individual Site Status
Active, not recruiting
Facility Name
Hospital Universitario Vall d'Hebrón
City
Barcelona
ZIP/Postal Code
08035
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital de La Santa Creu i Sant Pau
City
Barcelona
ZIP/Postal Code
8041
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital San Pedro de Alcantara
City
Cáceres
ZIP/Postal Code
1003
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitario Virgen de la Victoria
City
Málaga
ZIP/Postal Code
29010
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitario Son Espases
City
Palma de Mallorca
ZIP/Postal Code
07120
Country
Spain
Individual Site Status
Recruiting
Facility Name
Complejo Hospitalario de Navarra - H. de Navarra, Hematología C/ de Irunlarrea, 3, Pamplona
City
Pamplona
ZIP/Postal Code
31008
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitario de Salamanca
City
Salamanca
ZIP/Postal Code
37007
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitario Doctor Peset
City
Valencia
ZIP/Postal Code
46017
Country
Spain
Individual Site Status
Recruiting
Facility Name
H. Quirón Zaragoza
City
Zaragoza
ZIP/Postal Code
50012
Country
Spain
Individual Site Status
Recruiting
Facility Name
National Taiwan University Hospital
City
Taipei City
State/Province
Taipei
ZIP/Postal Code
100
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
Chang Gung Medical Foundation - ChiaYi Chang Gung Memorial Hospital - Chiayi Branch
City
Chiayi City
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
Kaohsiung Medical University - Chung-Ho Memorial Hospital
City
Kaohsiung
ZIP/Postal Code
807
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
China Medical University Hospital
City
Taichung
ZIP/Postal Code
40447
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
Ramathibodi Hospital - Mahidol University - Hematology
City
Bangkok
ZIP/Postal Code
10400
Country
Thailand
Individual Site Status
Recruiting
Facility Name
Siriraj Hospital
City
Bangkok
ZIP/Postal Code
10700
Country
Thailand
Individual Site Status
Recruiting
Facility Name
Thammasat University Hospital
City
Khlong Luang
ZIP/Postal Code
12120
Country
Thailand
Individual Site Status
Recruiting
Facility Name
Srinagarind Hospital (KhonKaen University)
City
Khon Kaen
ZIP/Postal Code
40002
Country
Thailand
Individual Site Status
Recruiting
Facility Name
Songklanagarind Hospital
City
Songkhla
ZIP/Postal Code
90110
Country
Thailand
Individual Site Status
Recruiting
Facility Name
Sakarya Research and Training Hospital
City
Adapazarı
ZIP/Postal Code
54100
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Ankara University Faculty of Medicine
City
Ankara
ZIP/Postal Code
06500
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Gazi University Medical Faculty
City
Ankara
ZIP/Postal Code
06500
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Pamukkale University
City
Denizli
ZIP/Postal Code
20160
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Gaziantep University Faculty of Medicine
City
Gaziantep
ZIP/Postal Code
27100
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Inonu University Turgut Ozal Medical Center
City
Malatya
ZIP/Postal Code
44280
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Mersin University Medical Faculty
City
Mersin
ZIP/Postal Code
33110
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Ondokuz Mayis University Medical Faculty - Hematology
City
Samsun
ZIP/Postal Code
55280
Country
Turkey
Individual Site Status
Recruiting
Facility Name
University Hospitals Birmingham NHS Foundation Trust
City
Birmingham
Country
United Kingdom
Individual Site Status
Active, not recruiting
Facility Name
NHS Greater Glasgow and Clyde
City
Glasgow
Country
United Kingdom
Individual Site Status
Active, not recruiting
Facility Name
Guy's and Saint Thomas' NHS Foundation Trust
City
London
ZIP/Postal Code
SE1 9RT
Country
United Kingdom
Individual Site Status
Active, not recruiting
Facility Name
Oxford University Hospitals NHS Foundation Trust
City
Oxford
Country
United Kingdom
Individual Site Status
Active, not recruiting

12. IPD Sharing Statement

Citations:
Citation
Al-Ali, H.K.; Delgado, R.G.; Lange, A.; Pluta, A.; McLornan, D.; Vachhani, P.; Damaj, G.L.; Jost, P.J.; Rejto, L.; Hus, M.; et al. KRT-232, A First-In-Class, Murine Double Minute 2 Inhibitor, for Myelofibrosis Relapsed or Refractory to Janus-Associated Kinase Inhibitor Treatment. Eha. Libr. 2020, 295035, S215
Results Reference
background

Learn more about this trial

KRT-232 Versus Best Available Therapy for the Treatment of Subjects With Myelofibrosis Who Are Relapsed or Refractory to JAK Inhibitor Treatment

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