The Effect of G-CSF on MRD After Induction Therapy in Newly Diagnosed AML
Granulocyte Colony-stimulating Factor, Minimal Residual Disease, Acute Myeloid Leukemia
About this trial
This is an interventional supportive care trial for Granulocyte Colony-stimulating Factor
Eligibility Criteria
Inclusion Criteria:
Newly diagnosed AML exclusively of APL; 14-65 years old; Neutrophil < 1.5 G/L at the day three after induction.
Exclusion Criteria:
Any abnormality in a vital sign (e.g., heart rate, respiratory rate, or blood pressure); Patients with any conditions not suitable for the trial; NR at day 28 after induction.
Sites / Locations
- Department of Hematology,Nanfang Hospital, Southern Medical UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
G-CSF treatment
G-CSF-free
In G-CSF treatment group, all participants are treated with G-CSF at the dose of 5ug/kg per day until neutrophil higher than 0.5 g/L or 14 days from day three after induction therapy. MRD is monitored at day 14 and 28 with flow cytometry and quantity PCR if a fusion gene is available.
In G-CSF-free group, no participants with newly diagnosed AML are treated with G-CSF after induction therapy.