Comparing Analgesic Efficacy of Systemic Lidocaine Against Placebo in General Anesthesia in Bariatric Surgery (COALAS)
Pain, Postoperative
About this trial
This is an interventional treatment trial for Pain, Postoperative focused on measuring systemic lidocain
Eligibility Criteria
Inclusion Criteria:
- elective laparoscopic bariatric surgery
- ASA classification I - III
- age 18 - 80
- given informed consent
Exclusion Criteria:
- no written consent
- allergy to the investigational product
- cardiac arrhythmia (pacemaker)
- liver dysfunction (Child-Pugh classification A, B or C)
- pregnancy
- central nervous disease
- chronic pain and pre-existing opiate prescription
- expected non-compliance
- drug/alcohol abuse
Sites / Locations
- Cantonal Hospital of St. Gallen
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Lidocaine Hydrochloride
Saline Solution
1.5 mg/kg lean body mass lidocaine (lidocaine 1%) bolus I.V. as general anesthesia steady state concentration is accomplished 1.5 mg/kg lean body mass/h lidocaine I.V. with beginning of surgical procedures after completion of surgery: transfer to PACU, pain evaluation for 48 hours duration of intervention: lidocaine infusion up to four hours from completion of surgery, or till transfer to surgical ward
0.15 ml/kg lean body mass saline 0.9% bolus I.V. as general anesthesia steady state concentration is accomplished 0.15 ml/kg lean body mass/h saline 0.9% I.V. with beginning of surgical procedure after completion of surgery: transfer to PACU, pain evaluation for 48 hours duration of intervention: saline infusion up to four hours from completion of surgery, or till transfer to surgical ward