Caffeine Consumption in Glaucoma Patients and Healthy Subjects
Glaucoma, Primary Open Angle
About this trial
This is an interventional diagnostic trial for Glaucoma, Primary Open Angle focused on measuring Primary Open Angle Glaucoma (POAG), Optical Coherence Tomography Angiography (OCTA), Caffeine, Macular Blood Flow, Peripapillary Blood Flow
Eligibility Criteria
Inclusion Criteria:
- age 18 to 90 years
- diagnosis of primary open angle glaucoma (Mild, Moderate and Advanced)
- healthy subjects with no eye disease
Exclusion Criteria:
- Diseases, ophthalmic or systemic, that are likely to affect OCTA results
- greater than moderate cataract
- nystagmus
- inability to look at target
- macular degeneration other than mild drusen or pigmentary changes
- diabetic retinopathy
- neovascular glaucoma or non-glaucoma optic neuropathies
- current macular edema, prior laser to retina, inflammatory retinopathy or choroidopathy
- keratoconus, corneal ectasia, central corneal scarring
- rheumatologic diseases or Raynaud's phenomena
- pregnant and lactating women
- mental illness or alcohol addiction
- pre-existing bladder symptoms, cardiac disease or sleep disorder
- refractive spherical diopter greater than 5 or cylinder greater than 3
- possible tolerance to caffeine (drinking more than 1 cup coffee per day).
Sites / Locations
- Wills Eye Glaucoma ServiceRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Glaucoma Patients
Healthy controls
Eligible participants include patients with mild, moderate or advanced primary open angle glaucoma (POAG) or primary angle closure glaucoma (PACG). Each participant will complete baseline study tasks. Each participant will then receive one 200 mg caffeine tablet to ingest. Study tasks will be performed 1 hour and 2 hours after caffeine ingestion.
Eligible participants include healthy subjects with no eye diseases. Each participant will complete baseline study tasks. Each participant will then receive one 200 mg caffeine tablet to ingest. Study tasks will be performed 1 hour and 2 hours after caffeine ingestion.