Increased Ketorolac Administration After Cesarean Section and Its Effect on Opioid Use: a Randomized Control Trial
Post-operative Pain, Post-partum Pain, Cesarean Section Complications
About this trial
This is an interventional treatment trial for Post-operative Pain focused on measuring ketorolac, opiate, cesarean section
Eligibility Criteria
Inclusion Criteria:
- Women presenting for care at Tufts Medical Center as an outpatient in obstetrics clinic or on Labor and Delivery.
- The subject must have had a cesarean section for any indication at Tufts Medical Center to be randomized to the study
- The subject is willing to have a phone call follow up conversation 2 weeks after their surgery.
Exclusion Criteria:
- Patients with allergy to ketorolac, NSAIDS or aspirin
- Patients with peptic ulcer disease, preexisting kidney or liver disease.
- Duramorph is not used as the anesthetic for the spinal/epidural during the cesarean section.
- Patient is hemodynamically unstable due to hemorrhage.
- Patient requires therapeutic anticoagulation in the post-operative period
- Patients with peripartum cardiomyopathy
- Provider decision to exclude patient.
- Patient diagnosis of chronic hypertension, gestational hypertension, preeclampsia, HELLP syndrome, or eclampsia
- A study subject may participate in another research study while participating in this research study.
Sites / Locations
- Tufts Medical Center
Arms of the Study
Arm 1
Arm 2
No Intervention
Experimental
Standard Protocol
Ketorolac Protocol
Subjects randomized to the standard group will receive the standard postoperative pain protocol that is currently used at Tufts Medical Center. It includes two doses of IV Ketorolac every 6 hours as needed for postoperative pain. Ibuprofen would be ordered 6 hours following the last dose after the last study drug.
Subjects randomized to the Ketorolac protocol will receive the study postoperative pain protocol. This includes 6 doses of IV Ketorolac, scheduled every 6 hours. The first dose is administered in the operating room or post-operative care unit.