Improving Cognition in People With Progressive Multiple Sclerosis Using Aerobic Exercise and Cognitive Rehabilitation
Multiple Sclerosis, Primary Progressive, Cognitive Impairment
About this trial
This is an interventional other trial for Multiple Sclerosis, Primary Progressive
Eligibility Criteria
Inclusion Criteria:
- Have a confirmed diagnosis of progressive Multiple Sclerosis
- Visual Acuity of 20/70
- Language comprehension, to ensure subjects have the ability to understand instructions
Exclusion Criteria:
- Wheelchair dependent (EDSS > 7.0)
- History of central nervous system disease other than progressive MS
- Steroids use within the past 3 months
- Regular aerobic training (eg. bi-cycling, running, swimming or rowing)
- Unwilling to travel to study sites for rehabilitation 2 times a week for 3 months
Sites / Locations
- Sunnybrook Health Science Center
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Sham Comparator
Sham Comparator
Sham Comparator
Active Comparator
Cognitive Rehab & Sham Exercise
Sham Cognitive Rehab & Sham Exercise
Sham Cognitive rehab & Aerobic Exercise
Cognitive Rehab & Aerobic Exercise
Cognitive Rehabilitation by computer based brain tasks, and Sham exercises focusing primary on balance and stretching. Sessions will take place twice a week for 12 weeks.
Sham cognitive Rehabilitation will consist of basic internet searches and learning to use a computer, and sham exercises focusing primary on balance and stretching. Sessions will take place twice a week for 12 weeks.
Sham cognitive rehabilitation will consist of basic internet searches and learning to use a computer, and aerobic exercises will focus primarily on improving cardio-respiratory fitness using a recumbent bike. Sessions will take place twice a week for 12 weeks.
Cognitive Rehabilitation by computer based brain tasks and aerobic exercises will focus primarily on improving cardio-respiratory fitness using a recumbent bike. Sessions will take place twice a week for 12 weeks.