Brain Excitability and Connectivity in Sensory-motor Pathways in ALS (SOM_ALS)
Amyotrophic Lateral Sclerosis
About this trial
This is an interventional basic science trial for Amyotrophic Lateral Sclerosis focused on measuring Brain excitability, Brain connectivity, Motor cortex, Somatosensory cortex
Eligibility Criteria
Inclusion Criteria:
- ALS, MRC score ≥ 4 at least in one hand
- Controls: no history of neurological disorders, right-handed
Exclusion Criteria:
- contraindication to MRI
Sites / Locations
- Hopital Pitie-SalpetriereRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Experimental
functional MRI
structural MRI
EEG/MEG
a group of patients with ALS and a group of gender and age matched healthy subjects will have functional MRI acquisition conditioned by electrical and mechanical stimuli of ADM proprioceptors
a group of patients with ALS and a group of gender and age matched healthy subjects will have diffusion MRI acquisition to evaluate their brain structures
a group of patients with ALS and a group of gender and age matched healthy subjects will have functional MRI acquisition conditioned by electrical stimuli of ADM proprioceptors